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Hrh1
Gene Detail
 Symbol
Name
ID
Hrh1
histamine receptor H1
MGI:107619
Synonyms Bphs, Hir
Feature Type protein coding gene
Genetic Map
Chromosome 6
53.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr6:114397936-114483296 bp, + strand
From VEGA annotation of GRCm38

  85361 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:668  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: H1 histamine receptor
Gene Tree: Hrh1

Human
homologs
Human Homolog HRH1, histamine receptor H1
NCBI Gene ID 3269
neXtProt AC  NX_P35367
Human Synonyms  H1-R, hisH1
Human Chr (Location)  3p25; chr3:11137093-11263253 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Spontaneous(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants show decrease in exploratory behavior, diurnal activity, aggression, anxiety, serotonin release, respiratory reaction to temperature and leptin response. Natural variants affect B. pertussis induced vasoactive amine sensitization.
 
Interactions
Hrh1 interacts with 229 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process calcium ion import, calcium ion transmembrane transport, ...
Component integral component of membrane, membrane, ...
Function calcium ion transmembrane transporter activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (10)    Tissues (8)    Images (1)
Theiler Stages: 1, 2, 3, 4, 28
Assay TypeResults
RNA in situ 1
Northern blot 1
RT-PCR 8
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(4) cDNA(7) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000034565 (Evidence)
Ensembl Gene ModelENSMUSG00000053004 (Evidence)
Entrez Gene15465 (Evidence)
UniGene333327
DFCITC1582834
DoTSDT.101704860, DT.101706578, DT.91322944, DT.99857394
NIA Mouse Gene IndexU007287, U368443
Consensus CDS ProjectCCDS20435.1
International Mouse Knockout Project StatusHrh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034565 VEGA Gene Model | MGI Sequence Detail 85361 C57BL/6J ±  kb
transcript OTTMUST00000087696 VEGA | MGI Sequence Detail 2782 Not Applicable 
polypeptide OTTMUSP00000047733 VEGA | MGI Sequence Detail 488 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(12) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(619 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000921 Histamine H1 receptor
Protein Ontology PR:000001422 histamine H1 receptor
References (Earliest) J:4933 Sudweeks JD, et al., Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3700-4
(Latest) J:209809 Diehl SA, et al., G proteins Galphai1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization. Infect Immun. 2014 Feb;82(2):773-82
All references(93)
Other
accession IDs
MGD-MRK-1616, MGD-MRK-36193, MGI:88188

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory