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Hrh1
Gene Detail
Symbol

Name
ID
Hrh1
histamine receptor H1
MGI:107619
Synonyms
Bphs, Hir
Feature Type
protein coding gene
Genetic Map
Chromosome 6
53.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr6:114397936-114483296 bp, + strand
From VEGA annotation of GRCm38

  85361 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:668  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HRH1
Protein SuperFamily: H1 histamine receptor
Gene Tree: Hrh1

Human
homologs
HRH1, histamine receptor H1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3269
neXtProt AC: NX_P35367

Human Synonyms: H1R, H1-R, HH1R, hisH1

Human Chr (Location): 3p25; chr3:11137093-11263253 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Spontaneous(3) Targeted(1)
Genomic Mutations involving Hrh1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants show decrease in exploratory behavior, diurnal activity, aggression, anxiety, serotonin release, respiratory reaction to temperature and leptin response. Natural variants affect B. pertussis induced vasoactive amine sensitization.
 
Interactions
Hrh1 interacts with 229 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (10)    Tissues (8)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
Northern blot 1
RT-PCR 8
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN hrh1    NEW 
Molecular
reagents
All nucleic(13) Genomic(4) cDNA(7) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000034565 (Evidence)
Ensembl Gene Model ENSMUSG00000053004 (Evidence)
Entrez Gene 15465 (Evidence)
UniGene 333327
DFCI TC1582834
DoTS DT.101704860, DT.101706578, DT.91322944, DT.99857394
NIA Mouse Gene Index U007287, U368443
Consensus CDS Project CCDS20435.1
International Mouse Phenotyping Consortium Status Hrh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034565 VEGA Gene Model | MGI Sequence Detail 85361 C57BL/6J ±  kb
transcript OTTMUST00000087696 VEGA | MGI Sequence Detail 2782 Not Applicable 
polypeptide OTTMUSP00000047733 VEGA | MGI Sequence Detail 488 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(12) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(619 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000921 Histamine H1 receptor
Protein Ontology PR:000001422 histamine H1 receptor
References
(Earliest) J:4933 Sudweeks JD, et al., Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3700-4
(Latest) J:220488 Murakami M, et al., Involvement of the histamine H1 receptor in the regulation of sympathetic nerve activity. Biochem Biophys Res Commun. 2015 Mar 13;458(3):584-9
All references(96)
Other
accession IDs
MGD-MRK-1616, MGD-MRK-36193, MGI:88188

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory