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Srebf1
Gene Detail
Symbol

Name
ID
Srebf1
sterol regulatory element binding transcription factor 1
MGI:107606
Synonyms
ADD-1, bHLHd1, SREBP1, SREBP-1, SREBP-1a, SREBP1c, SREBP-1c
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:60199089-60222581 bp, - strand
From VEGA annotation of GRCm38

  23493 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3079  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SREBF1
Protein SuperFamily: sterol regulatory element-binding protein
Gene Tree: Srebf1

Human
homologs
SREBF1, sterol regulatory element binding transcription factor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6720
neXtProt AC: NX_P36956

Human Synonyms: bHLHd1, SREBP1, SREBP-1c

Human Chr (Location): 17p11.2; chr17:17811349-17837017 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(27) Targeted(7) Transgenic(2)
Genomic Mutations involving Srebf1 (3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele of transcript A die between E11.5 and E14.5. Mice homozygous for a knock-out allele of transcript C exhibit decreased circulating triglyceride levels. Mice homozygous for a gene trap allele exhibit decreased hepatic triglyceride storage.
 
Mutations Annotated to Human Diseases (4)   
Interactions
Srebf1 interacts with 139 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process cellular response to starvation, cholesterol metabolic process, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (247)    Tissues (166)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 236
Northern blot 3
RT-PCR 8
cDNA source data(282)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase srebf1 ; ZFIN srebf1    NEW 
Molecular
reagents
All nucleic(287) Genomic(1) cDNA(284) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005809 (Evidence)
Ensembl Gene Model ENSMUSG00000020538 (Evidence)
Entrez Gene 20787 (Evidence)
UniGene 278701
DFCI TC1597304, TC1573402
NIA Mouse Gene Index U032863
Consensus CDS Project CCDS24785.1
International Mouse Phenotyping Consortium Status Srebf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005809 VEGA Gene Model | MGI Sequence Detail 23493 C57BL/6J ±  kb
transcript OTTMUST00000012870 VEGA | MGI Sequence Detail 4299 Not Applicable 
polypeptide OTTMUSP00000005985 VEGA | MGI Sequence Detail 1134 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(14) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(155 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000015611 sterol regulatory element-binding protein 1
References
(Earliest) J:34178 Welch CL, et al., Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul;37(7):1406-21
(Latest) J:222135 Lee GY, et al., PIASy-mediated sumoylation of SREBP1c regulates hepatic lipid metabolism upon fasting signaling. Mol Cell Biol. 2014 Mar;34(6):926-38
All references(117)
Other
accession IDs
MGD-MRK-36180

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory