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Srebf1 Gene Detail
Summary
  • Symbol
    Srebf1
  • Name
    sterol regulatory element binding transcription factor 1
  • Synonyms
    ADD-1, bHLHd1, SREBP1, SREBP-1, SREBP-1a, SREBP1c, SREBP-1c
  • Feature Type
    protein coding gene
  • IDs
    MGI:107606
    NCBI Gene: 20787
  • Gene Overview
    MyGene.info: SREBF1
Location & Maps
more
  • Sequence Map
    Chr11:60199089-60222581 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23493 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.81 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    SREBF1, sterol regulatory element binding transcription factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SREBF1, sterol regulatory element binding transcription factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHd1, SREBP1, SREBP1a, SREBP-1c
  • Links
    NCBI Gene ID: 6720
    neXtProt AC: NX_P36956

  • Chr Location
    17p11.2; chr17:17811349-17837017 (-)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 4 alleles in 5 genetic backgrounds
    85 phenotypes from multigenic genotypes
    1 images
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    41
  • Chemically induced (other)
    1
  • Gene trapped
    27
  • Targeted
    7
  • Transgenic
    6
  • Genomic Mutations
    4 involving Srebf1
  • Incidental Mutations
Mice homozygous for a knock-out allele of transcript A die between E11.5 and E14.5. Mice homozygous for a knock-out allele of transcript C exhibit decreased circulating triglyceride levels. Mice homozygous for a gene trap allele exhibit decreased hepatictriglyceride storage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005809 VEGA Gene Model | MGI Sequence Detail 23493 C57BL/6J ±  kb
transcript OTTMUST00000012870 VEGA | MGI Sequence Detail 4299 Not Applicable  
polypeptide OTTMUSP00000005985 VEGA | MGI Sequence Detail 1134 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    155 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 287
    Genomic 1
    cDNA 284
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36180
References
more
  • Summaries
    All 124
    Developmental Gene Expression 22
    Diseases 4
    Gene Ontology 26
    Phenotypes 67
  • Earliest
    J:34178 Welch CL, et al., Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul;37(7):1406-21
  • Latest
    J:234400 Tian J, et al., Insulin induction of SREBP-1c in rodent liver requires LXRalpha-C/EBPbeta complex. Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8182-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory