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Srebf1
Gene Detail
Symbol

Name
ID
Srebf1
sterol regulatory element binding transcription factor 1
MGI:107606
Synonyms
ADD-1, bHLHd1, SREBP1, SREBP-1, SREBP-1a, SREBP1c, SREBP-1c
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:60199089-60222581 bp, - strand
From VEGA annotation of GRCm38

  23493 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3079  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: sterol regulatory element-binding protein
Gene Tree: Srebf1

Human
homologs
Human Homolog SREBF1, sterol regulatory element binding transcription factor 1
NCBI Gene ID 6720
neXtProt AC  NX_P36956
Human Synonyms  bHLHd1, SREBP1, SREBP-1c
Human Chr (Location)  17p11.2; chr17:17811349-17837017 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(27) Targeted(7)
Genomic Mutations involving Srebf1 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele of transcript A die between E11.5 and E14.5. Mice homozygous for a knock-out allele of transcript C exhibit decreased circulating triglyceride levels. Mice homozygous for a gene trap allele exhibit decreased hepatic triglyceride storage.
 
Alleles Annotated to Human Diseases(3)   
Interactions
Srebf1 interacts with 140 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (57 annotations)
Process cellular response to starvation, cholesterol metabolic process, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (247)    Tissues (166)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 236
Northern blot 3
RT-PCR 8
cDNA source data(282)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(287) Genomic(1) cDNA(284) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005809 (Evidence)
Ensembl Gene ModelENSMUSG00000020538 (Evidence)
Entrez Gene20787 (Evidence)
UniGene278701
DFCITC1573402, TC1597304
NIA Mouse Gene IndexU032863
Consensus CDS ProjectCCDS24785.1
International Mouse Knockout Project StatusSrebf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005809 VEGA Gene Model | MGI Sequence Detail 23493 C57BL/6J ±  kb
transcript OTTMUST00000012870 VEGA | MGI Sequence Detail 4299 Not Applicable 
polypeptide OTTMUSP00000005985 VEGA | MGI Sequence Detail 1134 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(12) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(155 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000015611 sterol regulatory element-binding protein 1
References
(Earliest) J:34178 Welch CL, et al., Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul;37(7):1406-21
(Latest) J:213021 Ruiz R, et al., Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver. J Biol Chem. 2014 Feb 28;289(9):5510-7
All references(118)
Other
accession IDs
MGD-MRK-36180

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory