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Symbol
Name
ID
Srebf1
sterol regulatory element binding transcription factor 1
MGI:107606
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Increased LDL cholesterol concentration
Hypercholesterolemia
Hypertriglyceridemia
Glucose intolerance
Diabetes mellitus
Type II diabetes mellitus
Impaired glucose tolerance
Insulin resistance
Disease(s) Associated with SREBF1
coronary artery disease
type 2 diabetes mellitus

Mouse Phenotypes
homeostasis/metabolism phenotype
increased circulating ketone body level
decreased circulating cholesterol level
decreased circulating triglyceride level
increased liver cholesterol level
abnormal triglyceride level
decreased liver triglyceride level
Availability Mouse Genotype
Srebf1Gt(XC354)Byg/Srebf1Gt(XC354)Byg
Srebf1tm1Jdh/Srebf1tm1Jdh
Srebf1tm1Mbr/Srebf1tm1Mbr *
Srebf1tm2Jdh/Srebf1tm2Jdh

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory