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Sp4
Gene Detail
 Symbol
Name
ID
Sp4
trans-acting transcription factor 4
MGI:107595
Synonyms 5730497N03Rik, HF-1b, HF1-b
Feature Type protein coding gene
Genetic Map
Chromosome 12
63.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:118234933-118301440 bp, - strand
From NCBI annotation of GRCm38

  66508 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2341  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor, Sp1/Sp2/Sp3/Sp4 types
Gene Tree: Sp4

Human
homologs
Human Homolog SP4, Sp4 transcription factor
NCBI Gene ID 6671
neXtProt AC  NX_Q02446
Human Synonyms  HF1B, SPR-1
Human Chr (Location)  7p15.3; chr7:21428071-21514822 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(2) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit cardiac arrhythmias and most die shortly after birth. Surviving males complete spermatogenesis but do not copulate, while females show delayed sexual maturation and reduction in spleen, thymus, and uterus.
 
Human Diseases Modeled Using Mouse Sp4 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Sp4 interacts with 439 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process regulation of heart contraction, regulation of transcription, DNA-templated, ...
Component cytoplasm, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (64)    Tissues (62)    Images (5)
Theiler Stages: 2, 3, 4, 5, 15, 16, 17, 18, 19, 21, 23, 28
Assay TypeResults
RNA in situ 49
RT-PCR 15
cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(10) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000025323 (Evidence)
Entrez Gene20688 (Evidence)
DFCITC1586426, TC1629697, TC1631251
DoTSDT.101299101, DT.40146615, DT.91377528
NIA Mouse Gene IndexU034464, U034465
Consensus CDS ProjectCCDS36579.1
International Mouse Knockout Project StatusSp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20688 NCBI Gene Model | MGI Sequence Detail 66508 C57BL/6J ±  kb
transcript NM_009239 RefSeq | MGI Sequence Detail 9017 C57BL/6 
polypeptide Q62445 UniProt | EBI | MGI Sequence Detail 782 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(380 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000015442 transcription factor Sp4
Graphical View of Protein Domain Structure
References (Earliest) J:33573 Supp DM, et al., Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility. Dev Biol. 1996 Jun 15;176(2):284-99
(Latest) J:203465 Ji B, et al., Prolonged Ketamine Effects in Hypomorphic Mice: Mimicking Phenotypes of Schizophrenia. PLoS One. 2013;8(6):e66327
All references(47)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-36167, MGI:1917860

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory