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Sp4
Gene Detail
Symbol

Name
ID
Sp4
trans-acting transcription factor 4
MGI:107595
Synonyms
5730497N03Rik, HF-1b, HF1-b
Feature Type
protein coding gene
Genetic Map
Chromosome 12
63.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:118234933-118301440 bp, - strand
From Ensembl annotation of GRCm38

  66508 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2341  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SP4
Protein SuperFamily: transcription factor, Sp1/Sp2/Sp3/Sp4 types
Gene Tree: Sp4

Human
homologs
SP4, Sp4 transcription factor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6671
neXtProt AC: NX_Q02446

Human Synonyms: HF1B, SPR-1

Human Chr (Location): 7p15.3; chr7:21428071-21514822 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(2) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit cardiac arrhythmias and most die shortly after birth. Surviving males complete spermatogenesis but do not copulate, while females show delayed sexual maturation and reduction in spleen, thymus, and uterus.
 
Human Diseases Modeled in Mice Using Sp4 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Sp4 interacts with 438 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process regulation of heart contraction, regulation of transcription, DNA-templated, ...
Component cytoplasm, intercellular bridge, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (57)    Tissues (57)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 49
RT-PCR 8
cDNA source data(9)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase sp4 ; ZFIN sp4    NEW 
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(10) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000025323 (Evidence)
Entrez Gene 20688 (Evidence)
DFCI TC1631251, TC1629697, TC1586426
DoTS DT.91377528, DT.40146615, DT.101299101
NIA Mouse Gene Index U034464, U034465
Consensus CDS Project CCDS36579.1
International Mouse Phenotyping Consortium Status Sp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025323 Ensembl Gene Model | MGI Sequence Detail 66508 C57BL/6J ±  kb
transcript ENSMUST00000026367 Ensembl | MGI Sequence Detail 5770 Not Applicable 
polypeptide ENSMUSP00000026367 Ensembl | MGI Sequence Detail 782 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(380 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000015442 transcription factor Sp4
References
(Earliest) J:33573 Supp DM, et al., Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility. Dev Biol. 1996 Jun 15;176(2):284-99
(Latest) J:208781 Saia G, et al., Phosphorylation of the transcription factor Sp4 is reduced by NMDA receptor signaling. J Neurochem. 2014 May;129(4):743-52
All references(49)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-36167, MGI:1917860

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory