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Sp4 Gene Detail
Summary
  • Symbol
    Sp4
  • Name
    trans-acting transcription factor 4
  • Synonyms
    5730497N03Rik, HF-1b, HF1-b
  • Feature Type
    protein coding gene
  • IDs
    MGI:107595
    NCBI Gene: 20688
  • Gene Overview
    MyGene.info: SP4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:118234933-118301440 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      66508 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 63.48 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SP4, Sp4 transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SP4, Sp4 transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HF1B, SPR-1
  • Links
    NCBI Gene ID: 6671
    neXtProt AC: NX_Q02446
    UniProt: Q02446

  • Chr Location
    7p15.3; chr7:21428071-21514761 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Sp4 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 6 alleles in 6 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit cardiac arrhythmias and most die shortly after birth. Surviving males complete spermatogenesis but do not copulate, while females show delayed sexual maturation and reduction in spleen, thymus, and uterus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025323 Ensembl Gene Model | MGI Sequence Detail 66508 C57BL/6J ±  kb
    transcript ENSMUST00000222314 Ensembl | MGI Sequence Detail 2677 Not Applicable  
    polypeptide ENSMUSP00000152603 Ensembl | MGI Sequence Detail 782 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      387 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR030453 Transcription factor Sp4
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 10
      Primer pair 1
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36167, MGI:1917860
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:33573 Supp DM, et al., Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility. Dev Biol. 1996 Jun 15;176(2):284-99
    • Latest
      J:238550 Wegener A, et al., Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia. J Neurochem. 2017 Jan;140(2):245-256

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory