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Sp4 Gene Detail
Summary
  • Symbol
    Sp4
  • Name
    trans-acting transcription factor 4
  • Synonyms
    5730497N03Rik, HF-1b, HF1-b
  • Feature Type
    protein coding gene
  • IDs
    MGI:107595
    NCBI Gene: 20688
  • Gene Overview
    MyGene.info: SP4
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:118234933-118301440 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 63.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    387 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107595
protein coding gene Chr12:118231686-118301440 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020187
protein coding gene Chr12:121202037-121274516 (-)
A/J MGP_AJ_G0020143
protein coding gene Chr12:116720703-116790314 (-)
AKR/J MGP_AKRJ_G0020118
protein coding gene Chr12:120260296-120328419 (-)
BALB/cJ MGP_BALBcJ_G0020126
protein coding gene Chr12:117150584-117222959 (-)
C3H/HeJ MGP_C3HHeJ_G0019930
protein coding gene Chr12:120560264-120633784 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020573
protein coding gene Chr12:124986774-125058156 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018185
protein coding gene Chr12:113100013-113167025 (-)
CAST/EiJ MGP_CASTEiJ_G0019470
protein coding gene Chr12:114419684-114488968 (-)
CBA/J MGP_CBAJ_G0019897
protein coding gene Chr12:129910588-129979984 (-)
DBA/2J MGP_DBA2J_G0020014
protein coding gene Chr12:116120854-116194083 (-)
FVB/NJ MGP_FVBNJ_G0019999
protein coding gene Chr12:114787727-114854147 (-)
LP/J MGP_LPJ_G0020088
protein coding gene Chr12:121226370-121295964 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020035
protein coding gene Chr12:133159793-133231633 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020602
protein coding gene Chr12:119437723-119504159 (-)
PWK/PhJ MGP_PWKPhJ_G0019232
protein coding gene Chr12:110875246-110942925 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019037
protein coding gene Chr12:112393485-112461983 (-)
WSB/EiJ MGP_WSBEiJ_G0019528
protein coding gene Chr12:120416016-120483362 (-)



Homology
more
  • Human Ortholog
    SP4, Sp4 transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SP4, Sp4 transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HF1B, SPR-1
  • Links
    NCBI Gene ID: 6671
    neXtProt AC: NX_Q02446
    UniProt: Q02446

  • Chr Location
    7p15.3; chr7:21428071-21514761 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Sp4 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 6 alleles in 6 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit cardiac arrhythmias and most die shortly after birth. Surviving males complete spermatogenesis but do not copulate, while females show delayed sexual maturation and reduction in spleen, thymus, and uterus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025323 Ensembl Gene Model | MGI Sequence Detail 66508 C57BL/6J ±  kb
    transcript ENSMUST00000222314 Ensembl | MGI Sequence Detail 2677 Not Applicable  
    polypeptide ENSMUSP00000152603 Ensembl | MGI Sequence Detail 782 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR030453 Transcription factor Sp4
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 11
      Primer pair 1
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36167, MGI:1917860
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:33573 Supp DM, et al., Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility. Dev Biol. 1996 Jun 15;176(2):284-99
    • Latest
      J:258812 Wang X, et al., Ketamine independently modulated power and phase-coupling of theta oscillations in Sp4 hypomorphic mice. PLoS One. 2018;13(3):e0193446

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory