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Srebf2
Gene Detail
Symbol

Name
ID
Srebf2
sterol regulatory element binding factor 2
MGI:107585
Synonyms
bHLHd2, lop13, nuc, SREBP2, SREBP-2, SREBP2gc
Feature Type
protein coding gene
Genetic Map
Chromosome 15
38.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr15:82147269-82205379 bp, + strand
From NCBI annotation of GRCm38

  58111 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20966  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SREBF2
Protein SuperFamily: sterol regulatory element-binding protein
Gene Tree: Srebf2

Human
homologs
SREBF2, sterol regulatory element binding transcription factor 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6721
neXtProt AC: NX_Q12772

Human Synonyms: bHLHd2, SREBP2, SREBP-2

Human Chr (Location): 22q13; chr22:41833079-41907308 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Gene trapped(39) Radiation induced(1) Spontaneous(1) Transgenic(1)
Genomic Mutations involving Srebf2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele display prenatal lethality. Mice homozygous for an ENU mutation display cataracts and persistent wounds of the skin.
 
Phenotype Images(5)
Interactions
Srebf2 interacts with 241 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process cellular response to starvation, cholesterol metabolic process, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (111)    Tissues (83)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 111
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SREBF2 ; Xenbase srebf2    NEW 
Molecular
reagents
All nucleic(18) cDNA(17) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000022463 (Evidence)
Entrez Gene 20788 (Evidence)
DFCI TC1610426, TC1576318, TC1758984, TC1671854, TC1629927
DoTS DT.103569135, DT.101716268, DT.101404263, DT.94342507, DT.534133, DT.94342513, DT.97412683
NIA Mouse Gene Index U043465
Consensus CDS Project CCDS27683.1
International Mouse Phenotyping Consortium Status Srebf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20788 NCBI Gene Model | MGI Sequence Detail 58111 C57BL/6J ±  kb
transcript NM_033218 RefSeq | MGI Sequence Detail 4570 Not Specified 
polypeptide Q3U1N2 UniProt | EBI | MGI Sequence Detail 1130 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(270 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000015612 sterol regulatory element-binding protein 2
Graphical View of Protein Domain Structure
References
(Earliest) J:13874 Varnum D, Nuclear cataract (nuc). Mouse News Lett. 1981;64:59
(Latest) J:199237 Jeon TI, et al., An SREBP-Responsive microRNA Operon Contributes to a Regulatory Loop for Intracellular Lipid Homeostasis. Cell Metab. 2013 Jul 2;18(1):51-61
All references(81)
Other
accession IDs
MGD-MRK-11854, MGD-MRK-12947, MGD-MRK-36157, MGI:2146048, MGI:96806

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory