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Srebf2
Gene Detail
 Symbol
Name
ID
Srebf2
sterol regulatory element binding factor 2
MGI:107585
Synonyms bHLHd2, lop13, nuc, SREBP2, SREBP-2, SREBP2gc
Feature Type protein coding gene
Genetic Map
Chromosome 15
38.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr15:82147269-82204960 bp, + strand
From NCBI annotation of GRCm38

  57692 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20966  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: sterol regulatory element-binding protein
Gene Tree: Srebf2

Human
homologs
Human Homolog SREBF2, sterol regulatory element binding transcription factor 2
NCBI Gene ID 6721
neXtProt AC  NX_Q12772
Human Synonyms  bHLHd2, SREBP2, SREBP-2
Human Chr (Location)  22q13; chr22:41833079-41907308 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Gene trapped(39) Radiation induced(1) Spontaneous(1)
Genomic Mutations involving Srebf2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display prenatal lethality. Mice homozygous for an ENU mutation display cataracts and persistent wounds of the skin.
 
Phenotype Images(3)
Interactions
Srebf2 interacts with 242 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process cholesterol metabolic process, lipid metabolic process, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (111)    Tissues (83)    Images (8)
Theiler Stages: 15, 17, 18, 19, 21, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 111
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(17) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022463 (Evidence)
Entrez Gene20788 (Evidence)
DFCITC1576318, TC1610426, TC1629927, TC1671854, TC1758984
DoTSDT.101404263, DT.101716268, DT.103569135, DT.534133, DT.94342507, DT.94342513, DT.97412683
NIA Mouse Gene IndexU043465
Consensus CDS ProjectCCDS27683.1
International Mouse Knockout Project StatusSrebf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20788 NCBI Gene Model | MGI Sequence Detail 57692 C57BL/6J ±  kb
transcript NM_033218 RefSeq | MGI Sequence Detail 4570 Not Specified 
polypeptide Q3U1N2 UniProt | EBI | MGI Sequence Detail 1130 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(6) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(270 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000015612 sterol regulatory element-binding protein 2
Graphical View of Protein Domain Structure
References (Earliest) J:13874 Varnum D, Nuclear cataract (nuc). Mouse News Lett. 1981;64:59
(Latest) J:199237 Jeon TI, et al., An SREBP-Responsive microRNA Operon Contributes to a Regulatory Loop for Intracellular Lipid Homeostasis. Cell Metab. 2013 Jul 2;18(1):51-61
All references(83)
Other
accession IDs
MGD-MRK-11854, MGD-MRK-12947, MGD-MRK-36157, MGI:2146048, MGI:96806

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory