Xiap
Gene Detail

Symbol Name ID

Xiap X-linked inhibitor of apoptosis MGI:107572

Synonyms

1110015C02Rik, Aipa, Api3, Birc4, IAP3, ILP-1

Feature Type

protein coding gene

Genetic Map

Chromosome X

23.19 cM, cytoband A3-A5
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

ChrX:42059679-42109656 bp, + strand From VEGA annotation of GRCm38   49978 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:901  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: apoptosis inhibitor IAP homolog
Gene Tree: Xiap

Human homologs

Human Homolog		XIAP, X-linked inhibitor of apoptosis
NCBI Gene ID		331
neXtProt AC		NX_P98170
Human Synonyms		API3, BIRC4, hIAP3, hIAP-3, IAP-3, ILP1, MIHA, XLP2
Human Chr (Location)		Xq25; chrX:122993662-123047829 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human XIAP

Alleles and phenotypes

All alleles(58) : Targeted(6) Gene trapped(52)
 

Homozygous null mutants are indistinguishable from normal littermates, but increased levels of protein from other Birc gene family members suggest a compensatory mechanism in the absence of the Birc4 gene's product.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	apoptotic process, negative regulation of apoptotic process, ...
Component	cytoplasm, cytosol, ...
Function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ligase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (74)    Tissues (73)    Images (3)
Theiler Stages: 17, 21, 23, 28

Assay Type	Results
RNA in situ	28
RT-PCR	46

cDNA source data(112)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(118) Genomic(4) cDNA(112) Primer pair(2)
Microarray probesets(11)

Other database links

VEGA Gene Model	OTTMUSG00000017444 (Evidence)
Ensembl Gene Model	ENSMUSG00000025860 (Evidence)
Entrez Gene	11798 (Evidence)
UniGene	259879
DFCI	TC1586851, TC1601008, TC1612614, TC1673236, TC1685922, TC1736089
DoTS	DT.101195721, DT.110833510, DT.521740, DT.91340942, DT.94258090, DT.94258103
NIA Mouse Gene Index	U019817
EC	6.3.2.-
Consensus CDS Project	CCDS30098.1
International Mouse Knockout Project Status	Xiap

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017444	VEGA Gene Model | MGI Sequence Detail	49978	C57BL/6J
transcript	OTTMUST00000042313	VEGA | MGI Sequence Detail	6542	Not Applicable
polypeptide	OTTMUSP00000019010	VEGA | MGI Sequence Detail	496	Not Applicable

All sequences(65) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(29 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001370	Baculoviral inhibition of apoptosis protein repeat
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
Protein Ontology	PR:000003119	baculoviral IAP repeat-containing protein 4

References

(Earliest) J:33039 Uren AG, et al., Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4974-8
(Latest) J:188020 Damgaard RB, et al., The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. Mol Cell. 2012 Jun 29;46(6):746-58
All references(89)

Other accession IDs

MGD-MRK-36144, MGI:1922024