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Xiap Gene Detail
Summary
  • Symbol
    Xiap
  • Name
    X-linked inhibitor of apoptosis
  • Synonyms
    1110015C02Rik, Aipa, Api3, Birc4, IAP3, ILP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107572
    NCBI Gene: 11798
  • Alliance
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:41148556-41198533 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 23.19 cM, cytoband A3-A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107572
protein coding gene ChrX:41148483-41198541 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035674
protein coding gene ChrX:37121133-37174700 (+)
A/J MGP_AJ_G0035657
protein coding gene ChrX:37083874-37134989 (+)
AKR/J MGP_AKRJ_G0035577
protein coding gene ChrX:37981946-38034072 (+)
BALB/cJ MGP_BALBcJ_G0035643
protein coding gene ChrX:36771394-36822252 (+)
C3H/HeJ MGP_C3HHeJ_G0035347
protein coding gene ChrX:37439797-37491332 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036172
protein coding gene ChrX:37935483-37985818 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033024
protein coding gene ChrX:35198225-35248756 (+)
CAST/EiJ MGP_CASTEiJ_G0034638
protein coding gene ChrX:25273850-25326388 (+)
CBA/J MGP_CBAJ_G0035321
protein coding gene ChrX:38940233-38994403 (+)
DBA/2J MGP_DBA2J_G0035475
protein coding gene ChrX:36892217-36942453 (+)
FVB/NJ MGP_FVBNJ_G0035424
protein coding gene ChrX:36625141-36675123 (+)
LP/J MGP_LPJ_G0035563
protein coding gene ChrX:37439475-37489909 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035462
protein coding gene ChrX:39684325-39738466 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036190
protein coding gene ChrX:37076609-37128550 (+)
PWK/PhJ MGP_PWKPhJ_G0034337
protein coding gene ChrX:24819607-24869596 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034182
protein coding gene ChrX:25831045-25891661 (+)
WSB/EiJ MGP_WSBEiJ_G0034782
protein coding gene ChrX:36718260-36770371 (+)



Homology
more
  • Human Ortholog
    BIRC8, baculoviral IAP repeat containing 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BIRC8, baculoviral IAP repeat containing 8
  • Synonyms
    hILP2, ILP2, ILP-2, RNF136
  • Links
    NCBI Gene ID: 112401
    UniProt: Q96P09

  • Chr Location
    chr19:53289601-53291434 (-)  GRCh38

  • Human Ortholog
    XIAP, X-linked inhibitor of apoptosis
  • Synonyms
    API3, BIRC4, hIAP3, hIAP-3, IAP-3, ILP1, MIHA, XLP2
  • Links
    NCBI Gene ID: 331
    neXtProt AC: NX_P98170
    UniProt: P98170

  • Chr Location
    Xq25; chrX:123859708-123913972 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human XIAP associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    15 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are indistinguishable from normal littermates, but increased levels of protein from other Birc gene family members suggest a compensatory mechanism in the absence of the Birc4 gene's product.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025860 Ensembl Gene Model | MGI Sequence Detail 49978 C57BL/6J ±  kb
    transcript ENSMUST00000026978 Ensembl | MGI Sequence Detail 6834 Not Applicable  
    polypeptide ENSMUSP00000026978 Ensembl | MGI Sequence Detail 496 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 130
      Genomic 4
      cDNA 123
      Primer pair 3

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-36144, MGI:1922024
    References
    more
    • Summaries
      All 143
      Developmental Gene Expression 19
      Gene Ontology 12
      Phenotypes 57
    • Earliest
      J:33039 Uren AG, et al., Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4974-8
    • Latest
      J:328235 Chiang SCC, et al., Quercetin ameliorates XIAP deficiency-associated hyperinflammation. Blood. 2022 Aug 18;140(7):706-715

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory