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Xiap
Gene Detail
 Symbol
Name
ID
Xiap
X-linked inhibitor of apoptosis
MGI:107572
Synonyms 1110015C02Rik, Aipa, Api3, Birc4, IAP3, ILP-1
Feature Type protein coding gene
Genetic Map
Chromosome X
23.19 cM, cytoband A3-A5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:42059679-42109656 bp, + strand
From VEGA annotation of GRCm38

  49978 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:901  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: apoptosis inhibitor IAP homolog
Gene Tree: Xiap

Human
homologs
Human Homolog XIAP, X-linked inhibitor of apoptosis
NCBI Gene ID 331
neXtProt AC  NX_P98170
Human Synonyms  API3, BIRC4, hIAP3, hIAP-3, IAP-3, ILP1, MIHA, XLP2
Human Chr (Location)  Xq25; chrX:123859812-123913979 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human XIAP
Mutations,
alleles, and
phenotypes
All mutations/alleles(58) : Gene trapped(52) Targeted(6)
Incidental mutations (data from APF )
 
Homozygous null mutants are indistinguishable from normal littermates, but increased levels of protein from other Birc gene family members suggest a compensatory mechanism in the absence of the Birc4 gene's product.
 
Interactions
Xiap interacts with 413 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process apoptotic process, inhibition of cysteine-type endopeptidase activity involved in apoptotic process, ...
Component cytoplasm, cytosol, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (74)    Tissues (73)    Images (3)
Theiler Stages: 17, 21, 23, 28
Assay TypeResults
RNA in situ 28
RT-PCR 46
cDNA source data(121)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(127) Genomic(4) cDNA(121) Primer pair(2)
Microarray probesets(11)
Other database
links
VEGA Gene ModelOTTMUSG00000017444 (Evidence)
Ensembl Gene ModelENSMUSG00000025860 (Evidence)
Entrez Gene11798 (Evidence)
UniGene259879
DFCITC1586851, TC1601008, TC1612614, TC1651186, TC1673236, TC1685922, TC1736089
DoTSDT.101195721, DT.110833510, DT.521740, DT.91340942, DT.94258090, DT.94258103, DT.97391004
NIA Mouse Gene IndexU019817
EC6.3.2.-
Consensus CDS ProjectCCDS30098.1
International Mouse Knockout Project StatusXiap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017444 VEGA Gene Model | MGI Sequence Detail 49978 C57BL/6J ±  kb
transcript OTTMUST00000042337 VEGA | MGI Sequence Detail 6670 Not Applicable 
polypeptide OTTMUSP00000019025 VEGA | MGI Sequence Detail 496 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(19) UniProt(2)
Polymorphisms SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001370 Baculoviral inhibition of apoptosis protein repeat
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000003119 baculoviral IAP repeat-containing protein 4
References (Earliest) J:33039 Uren AG, et al., Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4974-8
(Latest) J:208703 Gentle IE, et al., Inhibitors of apoptosis proteins (IAPs) are required for effective T-cell expansion/survival during antiviral immunity in mice. Blood. 2014 Jan 30;123(5):659-68
All references(98)
Other
accession IDs
MGD-MRK-36144, MGI:1922024

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory