Xiap Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Xiap
X-linked inhibitor of apoptosis
MGI:107572

15 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Ripk1^tm1Led/Ripk1⁺ Xiap^tm1Vdr/Xiap^tm1Vdr involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6	decreased body size	J:182515
	postnatal lethality, incomplete penetrance	J:182515
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Ripk1^tm1Led/Ripk1^tm1Led Xiap^tm1Vdr/Xiap^tm1Vdr involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6	lethality throughout fetal growth and development, complete penetrance	J:182515
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Xiap^tm1Vdr/Xiap^tm1Vdr involves: 129S1/Sv * BALB/cJ * C57BL/6	abnormal heart atrium morphology	J:182515
	congestive heart failure	J:182515
	decreased cardiac muscle contractility	J:182515
	embryonic lethality during organogenesis, complete penetrance	J:182515
	enlarged pericardium	J:182515
	hemopericardium	J:182515
	hemorrhage	J:182515
Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Xiap^tm1Vdr/Xiap^tm1Vdr involves: 129S1/Sv * C57BL/6 * SJL	no abnormal phenotype detected	J:182515
Tg(IghMyc)22Bri/0 Xiap^tm1Hs/Xiap^tm1Hs B6.Cg-Xiap^tm1Hs Tg(IghMyc)22Bri	decreased B cell proliferation	J:138979
	decreased leukocyte cell number	J:138979
	increased B cell apoptosis	J:138979
	normal mortality/aging	J:138979

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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