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Sox17 Gene Detail
Summary
  • Symbol
    Sox17
  • Name
    SRY (sex determining region Y)-box 17
  • Feature Type
    protein coding gene
  • IDs
    MGI:107543
    NCBI Gene: 20671
Location & Maps
more
  • Genetic Map
    Chromosome 1, 1.65 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SOX17, SRY-box 17
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SOX17, SRY-box 17
    Orthology source: HomoloGene, HGNC
  • Synonyms
    VUR3
  • Links
    NCBI Gene ID: 64321
    neXtProt AC: NX_Q9H6I2

  • Chr Location
    8q11.23; chr8:54457935-54460896 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7948
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SOX17
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human SOX17 associations

Human Disease Mouse Models
       Vesicoureteral Reflux 3; VUR3   OMIM: 613674
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 8 alleles in 14 genetic backgrounds
    2 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (ENU)
    1
  • Targeted
    13
  • Incidental Mutations
Embryos homozygous for a targeted null mutation develop a deficient gut endoderm and die around embryonic day 10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050014 VEGA Gene Model | MGI Sequence Detail 6424 C57BL/6J ±  kb
transcript OTTMUST00000127245 VEGA | MGI Sequence Detail 3127 Not Applicable  
polypeptide OTTMUSP00000068696 VEGA | MGI Sequence Detail 419 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    43 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 43
    Genomic 1
    cDNA 38
    Primer pair 2
    Other 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-36114
References
more
  • Summaries
    All 142
    Developmental Gene Expression 85
    Gene Ontology 27
    Phenotypes 42
  • Earliest
    J:33784 Kanai Y, et al., Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J Cell Biol. 1996 May;133(3):667-81
  • Latest
    J:235032 Ma H, et al., MicroRNA-127 Promotes Mesendoderm Differentiation of Mouse Embryonic Stem Cells by Targeting Left-Right Determination Factor 2. J Biol Chem. 2016 Jun 3;291(23):12126-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory