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Sox17
Gene Detail
Symbol

Name
ID
Sox17
SRY (sex determining region Y)-box 17
MGI:107543
Feature Type
protein coding gene
Genetic Map
Chromosome 1
1.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:4490931-4497354 bp, - strand
From Ensembl annotation of GRCm38

  6424 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7948  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Sox17

Human
homologs
Human Homolog SOX17, SRY (sex determining region Y)-box 17
NCBI Gene ID 64321
neXtProt AC  NX_Q9H6I2
Human Synonyms  VUR3
Human Chr (Location)  8q11.23; chr8:54457935-54460896 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SOX17
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a targeted null mutation develop a deficient gut endoderm and die around embryonic day 10.5.
 
Interactions
Sox17 interacts with 135 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (79 annotations)
Process angiogenesis, canonical Wnt signaling pathway, ...
Component nuclear transcription factor complex, nucleus, ...
Function beta-catenin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (66 records)
Data Summary: Results (256)    Tissues (192)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 231
Western blot 8
RT-PCR 11
cDNA source data(38)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(1) cDNA(38) Primer pair(2) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000025902 (Evidence)
Entrez Gene20671 (Evidence)
UniGene279103
DFCITC1582235, TC1595152, TC1612276, TC1601513, TC1595463
DoTSDT.91580604, DT.91430997, DT.55277405, DT.101364158, DT.101364157
NIA Mouse Gene IndexU021094
PDB3F27
Consensus CDS ProjectCCDS14805.1
International Mouse Knockout Project StatusSox17
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025902 Ensembl Gene Model | MGI Sequence Detail 6424 C57BL/6J ±  kb
transcript ENSMUST00000027035 Ensembl | MGI Sequence Detail 3127 Not Applicable 
polypeptide ENSMUSP00000027035 Ensembl | MGI Sequence Detail 419 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(14) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR021934 Sox C-terminal transactivation domain
Protein Ontology PR:000015424 transcription factor SOX-17
References
(Earliest) J:33784 Kanai Y, et al., Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J Cell Biol. 1996 May;133(3):667-81
(Latest) J:213586 Jackson A, et al., Endoderm-specific deletion of Tbx1 reveals an FGF-independent role for Tbx1 in pharyngeal apparatus morphogenesis. Dev Dyn. 2014 Sep;243(9):1143-51
All references(117)
Other
accession IDs
MGD-MRK-36114

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory