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Sox17
Gene Detail
Symbol

Name
ID
Sox17
SRY (sex determining region Y)-box 17
MGI:107543
Feature Type
protein coding gene
Genetic Map
Chromosome 1
1.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:4490931-4497354 bp, - strand
From VEGA annotation of GRCm38

  6424 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7948  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: SOX17
Gene Tree: Sox17

Human
homologs
SOX17, SRY (sex determining region Y)-box 17
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 64321
neXtProt AC: NX_Q9H6I2

Human Synonyms: VUR3

Human Chr (Location): 8q11.23; chr8:54457935-54460896 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SOX17

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a targeted null mutation develop a deficient gut endoderm and die around embryonic day 10.5.
 
Interactions
Sox17 interacts with 137 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (80 annotations)
Process angiogenesis, canonical Wnt signaling pathway, ...
Component nuclear transcription factor complex, nucleus, ...
Function beta-catenin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (71 records)
Data Summary: Results (256)    Tissues (192)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 231
Western blot 8
RT-PCR 11
cDNA source data(38)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SOX17 ; Xenbase sox17a ; ZFIN sox17    NEW 
Molecular
reagents
All nucleic(43) Genomic(1) cDNA(38) Primer pair(2) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000050014 (Evidence)
Ensembl Gene Model ENSMUSG00000025902 (Evidence)
Entrez Gene 20671 (Evidence)
UniGene 279103
DFCI TC1595152, TC1582235, TC1612276, TC1601513, TC1595463
DoTS DT.55277405, DT.101364158, DT.101364157, DT.91430997, DT.91580604
NIA Mouse Gene Index U021094
PDB 3F27
Consensus CDS Project CCDS14805.1
International Mouse Phenotyping Consortium Status Sox17
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050014 VEGA Gene Model | MGI Sequence Detail 6424 C57BL/6J ±  kb
transcript OTTMUST00000127245 VEGA | MGI Sequence Detail 3127 Not Applicable 
polypeptide OTTMUSP00000068696 VEGA | MGI Sequence Detail 419 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(18) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR021934 Sox C-terminal transactivation domain
Protein Ontology PR:000015424 transcription factor SOX-17
References
(Earliest) J:33784 Kanai Y, et al., Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J Cell Biol. 1996 May;133(3):667-81
(Latest) J:219587 Geula S, et al., Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation. Science. 2015 Feb 27;347(6225):1002-6
All references(123)
Other
accession IDs
MGD-MRK-36114

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory