Sox17
Gene Detail

Symbol Name ID

Sox17 SRY-box containing gene 17 MGI:107543

Feature Type

protein coding gene

Genetic Map

Chromosome 1

1.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:4490928-4496413 bp, - strand From NCBI annotation of GRCm38   5486 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7948  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Sox17

Human homologs

Human Homolog		SOX17, SRY (sex determining region Y)-box 17
NCBI Gene ID		64321
neXtProt AC		NX_Q9H6I2
Human Synonyms		VUR3
Human Chr (Location)		8q11.23; chr8:55370495-55373456 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SOX17

Alleles and phenotypes

All alleles(11) : Targeted(11)
 

Embryos homozygous for a targeted null mutation develop a deficient gut endoderm and die around embryonic day 10.5.

 

Gene Ontology (GO) classifications

All GO classifications: (74 annotations)

Process	angiogenesis, canonical Wnt receptor signaling pathway, ...
Component	nucleus, transcription factor complex
Function	beta-catenin binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (50 records)
Data Summary: Results (263)    Tissues (197)    Images (46)
Theiler Stages: 2, 3, 4, 5, 8, 9, 10, 11, 12, 13, 17, 19, 20, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	231
Western blot	8
RT-PCR	18

cDNA source data(38)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(43) Genomic(1) cDNA(38) Primer pair(2) Other(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000025902 (Evidence)
Entrez Gene	20671 (Evidence)
UniGene	279103
DFCI	TC1582235, TC1595152, TC1595463, TC1601513, TC1612276
DoTS	DT.101364157, DT.101364158, DT.55277405, DT.91430997, DT.91580604
NIA Mouse Gene Index	U021094
PDB	3F27
Consensus CDS Project	CCDS14805.1
International Mouse Knockout Project Status	Sox17

Sequences

Length	Strain/Species
genomic	20671	NCBI Gene Model | MGI Sequence Detail	5486	C57BL/6J
transcript	NM_011441	RefSeq | MGI Sequence Detail	3130	C57BL/6
polypeptide	Q61473	UniProt | EBI | MGI Sequence Detail	419	Not Applicable

All sequences(35) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(31 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009071	High mobility group (HMG) box domain
InterPro	IPR021934	Sox C-terminal transactivation domain
Protein Ontology	PR:000015424	transcription factor SOX-17

Graphical View of Protein Domain Structure

References

(Earliest) J:33784 Kanai Y, et al., Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J Cell Biol. 1996 May;133(3):667-81
(Latest) J:195279 Thompson H, et al., Dual origin of the epithelium of the mammalian middle ear. Science. 2013 Mar 22;339(6126):1453-6
All references(95)

Other accession IDs

MGD-MRK-36114