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Pex2 Gene Detail
Summary
  • Symbol
    Pex2
  • Name
    peroxisomal biogenesis factor 2
  • Synonyms
    D3Ertd138e, PMP35, Pxmp3, Zellweger syndrome homolog
  • Feature Type
    protein coding gene
  • IDs
    MGI:107486
    NCBI Gene: 19302
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:5625248-5641299 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 1.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107486
protein coding gene Chr3:5625248-5643655 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027046
protein coding gene Chr3:2330180-2348013 (-)
A/J MGP_AJ_G0027010
protein coding gene Chr3:2686805-2704046 (-)
AKR/J MGP_AKRJ_G0026980
protein coding gene Chr3:2483661-2499699 (-)
BALB/cJ MGP_BALBcJ_G0027019
protein coding gene Chr3:2406463-2422511 (-)
C3H/HeJ MGP_C3HHeJ_G0026759
protein coding gene Chr3:2712698-2728746 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027464
protein coding gene Chr3:2799044-2820088 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024826
protein coding gene Chr3:2011480-2027509 (-)
CAST/EiJ MGP_CASTEiJ_G0026218
protein coding gene Chr3:2785630-2804530 (-)
CBA/J MGP_CBAJ_G0026738
protein coding gene Chr3:2546720-2562800 (-)
DBA/2J MGP_DBA2J_G0026873
protein coding gene Chr3:2296570-2312612 (-)
FVB/NJ MGP_FVBNJ_G0026840
protein coding gene Chr3:2238174-2254528 (-)
LP/J MGP_LPJ_G0026984
protein coding gene Chr3:2853944-2870044 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026860
protein coding gene Chr3:3201782-3218235 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027523
protein coding gene Chr3:2290276-2309243 (-)
PWK/PhJ MGP_PWKPhJ_G0025953
protein coding gene Chr3:2564524-2580844 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025755
protein coding gene Chr3:2468690-2499428 (-)
WSB/EiJ MGP_WSBEiJ_G0026289
protein coding gene Chr3:2326742-2343452 (-)



Homology
more
  • Human Ortholog
    PEX2, peroxisomal biogenesis factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PEX2, peroxisomal biogenesis factor 2
  • Synonyms
    PAF1, PBD5A, PBD5B, PMP3, PMP35, PXMP3, RNF72, ZWS3
  • Links
    NCBI Gene ID: 5828
    neXtProt AC: NX_P28328
    UniProt: P28328

  • Chr Location
    8q21.13; chr8:76980258-77001044 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with human PEX2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 1 allele in 2 genetic backgrounds
    4 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die sometime before weaning. Various abnormalities are seen in the central nervous system depending on the genetic background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040374 Ensembl Gene Model | MGI Sequence Detail 16052 C57BL/6J ±  kb
    transcript ENSMUST00000191916 Ensembl | MGI Sequence Detail 1376 Not Applicable  
    polypeptide ENSMUSP00000141945 Ensembl | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 11
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36054, MGI:1098626
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:47868 Shimozawa N, et al., A human gene responsible for Zellweger syndrome that affects peroxisome assembly. Science. 1992 Feb 28;255(5048):1132-4
    • Latest
      J:302030 Eberhart T, et al., Peroxisome-Deficiency and HIF-2alpha Signaling Are Negative Regulators of Ketohexokinase Expression. Front Cell Dev Biol. 2020;8:566

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory