Cd38
Gene Detail

Symbol Name ID

Cd38 CD38 antigen MGI:107474

Synonyms

Cd38-rs1

Feature Type

protein coding gene

Genetic Map

Chromosome 5

23.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr5:43868809-43912375 bp, + strand From VEGA annotation of GRCm38   43567 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1345  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: ADP-ribosyl cyclase CD38
Gene Tree: Cd38

Human homologs

Human Homolog		CD38, CD38 molecule
NCBI Gene ID		952
neXtProt AC		NX_P28907
Human Synonyms		T10
Human Chr (Location)		4p15; chr4:15779931-15850706 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(5) Gene trapped(6)
 

Homozygous mutation of this gene has resulted in an impaired antibody response to T cell dependent antigens and disrupted glucose-dependent insulin secretion.

 
Human Diseases Modeled Using Mouse Cd38 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	B cell receptor signaling pathway, elevation of cytosolic calcium ion concentration, ...
Component	cell surface, integral to membrane, ...
Function	hydrolase activity, hydrolase activity, acting on glycosyl bonds, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (143)    Tissues (142)    Images (17)
Theiler Stages: 12, 22, 23, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	94
RT-PCR	46

cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(34) cDNA(32) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000029024 (Evidence)
Ensembl Gene Model	ENSMUSG00000029084 (Evidence)
Entrez Gene	12494 (Evidence)
UniGene	249873
DFCI	TC1577863
DoTS	DT.101381050, DT.50315604
NIA Mouse Gene Index	U005547
EC	3.2.2.5
PDB	2EG9
Consensus CDS Project	CCDS19265.1
International Mouse Knockout Project Status	Cd38

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029024	VEGA Gene Model | MGI Sequence Detail	43567	C57BL/6J
transcript	OTTMUST00000072007	VEGA | MGI Sequence Detail	3014	Not Applicable
polypeptide	OTTMUSP00000036979	VEGA | MGI Sequence Detail	304	Not Applicable

All sequences(31) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(226 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003193	ADP-ribosyl cyclase (CD38/157)
InterPro	IPR016040	NAD(P)-binding domain
Protein Ontology	PR:000001408	ADP-ribosyl cyclase 1

References

(Earliest) J:14687 Harada N, et al., Expression cloning of a cDNA encoding a novel murine B cell activation marker. Homology to human CD38. J Immunol. 1993 Sep 15;151(6):3111-8
(Latest) J:191892 Wei WJ, et al., Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway. J Biol Chem. 2012 Oct 12;287(42):35599-611
All references(103)

Other accession IDs

MGD-MRK-1851, MGD-MRK-36041