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Cd38
Gene Detail
Symbol

Name
ID
Cd38
CD38 antigen
MGI:107474
Synonyms
Cd38-rs1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
23.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:43868553-43912375 bp, + strand
From VEGA annotation of GRCm38

  43823 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1345  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CD38
Protein SuperFamily: ADP-ribosyl cyclase CD38
Gene Tree: Cd38

Human
homologs
CD38, CD38 molecule
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 952
neXtProt AC: NX_P28907

Human Synonyms: ADPRC 1, T10

Human Chr (Location): 4p15; chr4:15778298-15849083 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(1) Gene trapped(6) Radiation induced(2) Targeted(5)
Genomic Mutations involving Cd38 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene has resulted in an impaired antibody response to T cell dependent antigens and disrupted glucose-dependent insulin secretion.
 
Human Diseases Modeled in Mice Using Cd38 (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(4)
Interactions
Cd38 interacts with 258 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process B cell receptor signaling pathway, long term synaptic depression, ...
Component cell surface, cytosol, ...
Function hydrolase activity, hydrolase activity, acting on glycosyl bonds, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (143)    Tissues (142)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 94
RT-PCR 46
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cd38    NEW 
Molecular
reagents
All nucleic(34) cDNA(32) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000029024 (Evidence)
Ensembl Gene Model ENSMUSG00000029084 (Evidence)
Entrez Gene 12494 (Evidence)
UniGene 249873
DFCI TC1577863
DoTS DT.101381050, DT.50315604
NIA Mouse Gene Index U005547
EC 2.4.99.20, 3.2.2.6
PDB 2EG9
Consensus CDS Project CCDS19265.1
International Mouse Phenotyping Consortium Status Cd38
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029024 VEGA Gene Model | MGI Sequence Detail 43823 C57BL/6J ±  kb
transcript OTTMUST00000072007 VEGA | MGI Sequence Detail 3270 Not Applicable 
polypeptide OTTMUSP00000036979 VEGA | MGI Sequence Detail 304 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(307 from dbSNP Build 137)    SNPs within 2kb including multiple locations(309)
Protein-related
information
ResourceIDDescription
InterPro IPR003193 ADP-ribosyl cyclase (CD38/157)
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000001408 ADP-ribosyl cyclase 1
References
(Earliest) J:14687 Harada N, et al., Expression cloning of a cDNA encoding a novel murine B cell activation marker. Homology to human CD38. J Immunol. 1993 Sep 15;151(6):3111-8
(Latest) J:220100 Romero-Ramirez H, et al., CD38 expression in early B-cell precursors contributes to extracellular signal-regulated kinase-mediated apoptosis. Immunology. 2015 Feb;144(2):271-81
All references(110)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1851, MGD-MRK-36041

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory