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Cd38
Gene Detail
 Symbol
Name
ID
Cd38
CD38 antigen
MGI:107474
Synonyms Cd38-rs1
Feature Type protein coding gene
Genetic Map
Chromosome 5
23.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:43868809-43912375 bp, + strand
From VEGA annotation of GRCm38

  43567 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1345  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ADP-ribosyl cyclase CD38
Gene Tree: Cd38

Human
homologs
Human Homolog CD38, CD38 molecule
NCBI Gene ID 952
neXtProt AC  NX_P28907
Human Synonyms  ADPRC 1, T10
Human Chr (Location)  4p15; chr4:15778298-15849083 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(1) Gene trapped(6) Radiation induced(1) Targeted(5)
Genomic Mutations involving Cd38 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene has resulted in an impaired antibody response to T cell dependent antigens and disrupted glucose-dependent insulin secretion.
 
Human Diseases Modeled Using Mouse Cd38 (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Cd38 interacts with 259 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process B cell receptor signaling pathway, long term synaptic depression, ...
Component cell surface, cytosol, ...
Function hydrolase activity, hydrolase activity, acting on glycosyl bonds, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (143)    Tissues (142)    Images (17)
Theiler Stages: 12, 22, 23, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 94
RT-PCR 46
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(32) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000029024 (Evidence)
Ensembl Gene ModelENSMUSG00000029084 (Evidence)
Entrez Gene12494 (Evidence)
UniGene249873
DFCITC1577863
DoTSDT.101381050, DT.50315604
NIA Mouse Gene IndexU005547
EC2.4.99.20, 3.2.2.6
PDB2EG9
Consensus CDS ProjectCCDS19265.1
International Mouse Knockout Project StatusCd38
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029024 VEGA Gene Model | MGI Sequence Detail 43567 C57BL/6J ±  kb
transcript OTTMUST00000072007 VEGA | MGI Sequence Detail 3014 Not Applicable 
polypeptide OTTMUSP00000036979 VEGA | MGI Sequence Detail 304 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(303 from dbSNP Build 137)    SNPs within 2kb including multiple locations(305)
Protein-related
information
ResourceIDDescription
InterPro IPR003193 ADP-ribosyl cyclase (CD38/157)
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000001408 ADP-ribosyl cyclase 1
References (Earliest) J:14687 Harada N, et al., Expression cloning of a cDNA encoding a novel murine B cell activation marker. Homology to human CD38. J Immunol. 1993 Sep 15;151(6):3111-8
(Latest) J:210880 Moss NG, et al., Renal vasoconstriction by vasopressin V1a receptors is modulated by nitric oxide, prostanoids, and superoxide but not the ADP ribosyl cyclase CD38. Am J Physiol Renal Physiol. 2014 May 15;306(10):F1143-54
All references(109)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1851, MGD-MRK-36041

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory