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Cd38 Gene Detail
Summary
  • Symbol
    Cd38
  • Name
    CD38 antigen
  • Synonyms
    Cd38-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107474
    NCBI Gene: 12494
  • Gene Overview
    MyGene.info: CD38
Location & Maps
more
  • Sequence Map
    Chr5:43868553-43912375 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43823 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 23.85 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CD38, CD38 molecule
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CD38, CD38 molecule
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADPRC1, ADPRC 1
  • Links
    NCBI Gene ID: 952
    neXtProt AC: NX_P28907

  • Chr Location
    4p15; chr4:15778298-15849083 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Cd38 mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    6
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    6 involving Cd38
  • Incidental Mutations
Homozygous mutation of this gene has resulted in an impaired antibody response to T cell dependent antigens and disrupted glucose-dependent insulin secretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029024 VEGA Gene Model | MGI Sequence Detail 43823 C57BL/6J ±  kb
transcript OTTMUST00000072007 VEGA | MGI Sequence Detail 3270 Not Applicable  
polypeptide OTTMUSP00000036979 VEGA | MGI Sequence Detail 304 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    305 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    cDNA 32
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-1851, MGD-MRK-36041
References
more
  • Summaries
    All 111
    Developmental Gene Expression 5
    Diseases 2
    Gene Ontology 9
    Phenotypes 75
  • Earliest
    J:14687 Harada N, et al., Expression cloning of a cDNA encoding a novel murine B cell activation marker. Homology to human CD38. J Immunol. 1993 Sep 15;151(6):3111-8
  • Latest
    J:220100 Romero-Ramirez H, et al., CD38 expression in early B-cell precursors contributes to extracellular signal-regulated kinase-mediated apoptosis. Immunology. 2015 Feb;144(2):271-81

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory