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Cd38 Gene Detail
Summary
  • Symbol
    Cd38
  • Name
    CD38 antigen
  • Synonyms
    Cd38-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107474
    NCBI Gene: 12494
  • Gene Overview
    MyGene.info: CD38
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:43868809-43912374 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 23.85 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    301 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107474
protein coding gene Chr5:43868553-43912375 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029526
protein coding gene Chr5:42501792-42546436 (+)
A/J MGP_AJ_G0029492
protein coding gene Chr5:41031779-41076965 (+)
AKR/J MGP_AKRJ_G0029442
protein coding gene Chr5:42492777-42537598 (+)
BALB/cJ MGP_BALBcJ_G0029503
protein coding gene Chr5:41511304-41555572 (+)
C3H/HeJ MGP_C3HHeJ_G0029226
protein coding gene Chr5:42468048-42512948 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029957
protein coding gene Chr5:44554010-44597755 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027196
protein coding gene Chr5:38263440-38310042 (+)
CAST/EiJ MGP_CASTEiJ_G0028634
protein coding gene Chr5:41583245-41629165 (+)
CBA/J MGP_CBAJ_G0029195
protein coding gene Chr5:45728622-45774852 (+)
DBA/2J MGP_DBA2J_G0029340
protein coding gene Chr5:41130553-41175010 (+)
FVB/NJ MGP_FVBNJ_G0029301
protein coding gene Chr5:40554400-40600722 (+)
LP/J MGP_LPJ_G0029426
protein coding gene Chr5:42970797-43014490 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029329
protein coding gene Chr5:46543437-46590041 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029990
protein coding gene Chr5:41984028-42029448 (+)
PWK/PhJ MGP_PWKPhJ_G0028358
protein coding gene Chr5:40258786-40304298 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028192
protein coding gene Chr5:41415237-41462747 (+)
WSB/EiJ MGP_WSBEiJ_G0028715
protein coding gene Chr5:42068156-42115378 (+)



Homology
more
  • Human Ortholog
    CD38, CD38 molecule
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CD38, CD38 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADPRC1, ADPRC 1
  • Links
    NCBI Gene ID: 952
    neXtProt AC: NX_P28907
    UniProt: P28907

  • Chr Location
    4p15.32; chr4:15778265-15853243 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Cd38 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene has resulted in an impaired antibody response to T cell dependent antigens and disrupted glucose-dependent insulin secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12494 NCBI Gene Model | MGI Sequence Detail 43566 C57BL/6J ±  kb
    transcript NM_007646 RefSeq | MGI Sequence Detail 3013 C57BL/6  
    polypeptide P56528 UniProt | EBI | MGI Sequence Detail 304 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 32
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1851, MGD-MRK-36041
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 12
      Phenotypes 92
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:263067 Garcia-Rodriguez S, et al., CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism. Sci Rep. 2018 Feb 20;8(1):3357

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory