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Cd38tm1Lnd
Targeted Allele Detail
Summary
Symbol: Cd38tm1Lnd
Name: CD38 antigen; targeted mutation 1, Frances E Lund
MGI ID: MGI:1861803
Synonyms: CD38-, CD38null, Cd38tm1Lud
Gene: Cd38  Location: Chr5:44026153-44069714 bp, + strand  Genetic Position: Chr5, 23.85 cM
Alliance: Cd38tm1Lnd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49170
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing exons 2 and 3, which encode the putative active site of the encoded protein. Homozygous mice lacked transcripts derived from this allele (data not shown). Flow cytometry analysis on splenocytes derived from homozygous mice confirmed that no detectable protein was expressed on the cell surface. (J:49170)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Cd38 Mutation:  50 strains or lines available
References
Original:  J:49170 Cockayne DA, et al., Mice deficient for the ecto-nicotinamide adenine dinucleotide. Blood. 1998 Aug 15;92(4):1324-33
All:  85 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory