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Plcb4
Gene Detail
 Symbol
Name
ID
Plcb4
phospholipase C, beta 4
MGI:107464
Synonyms A930039J07Rik, C230058B11Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
66.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:135659011-136014593 bp, + strand
From VEGA annotation of GRCm38

  355583 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8471  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta
Gene Tree: Plcb4

Human
homologs
Human Homolog PLCB4, phospholipase C, beta 4
NCBI Gene ID 5332
neXtProt AC  NX_Q15147
Human Synonyms  ARCND2, PI-PLC
Human Chr (Location)  20p12; chr20:9068710-9480816 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PLCB4
Mutations,
alleles, and
phenotypes
All mutations/alleles(114) : Gene trapped(108) Radiation induced(1) Targeted(5)
Genomic Mutations involving Plcb4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations may exhibit ataxia, impaired elimination of excess climbing fiber synapses in the developing cerebellum, abnormal cerebellar foliation, reduced visual processing ability and loss of circadian rhythm in constant darkness.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Plcb4 interacts with 344 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process lipid catabolic process, lipid metabolic process, ...
Component cytoplasm, dendrite, ...
Function hydrolase activity, mitogen-activated protein kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (203)    Tissues (129)    Images (57)
Theiler Stages: 22, 23, 26, 27, 28
Assay TypeResults
Immunohistochemistry 86
RNA in situ 117
cDNA source data(65)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(69) cDNA(67) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000015959 (Evidence)
Ensembl Gene ModelENSMUSG00000039943 (Evidence)
Entrez Gene18798 (Evidence)
UniGene38009
DFCITC1595369, TC1598899, TC1600969, TC1603214, TC1611691, TC1612196, TC1619529, TC1622059
DoTSDT.101370775, DT.101735851, DT.103566167, DT.488760, DT.87025407, DT.91289211, DT.91304823, DT.91323391, DT.91334166, DT.91422355
NIA Mouse Gene IndexU002527
EC3.1.4.11
Consensus CDS ProjectCCDS16788.1
International Mouse Knockout Project StatusPlcb4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015959 VEGA Gene Model | MGI Sequence Detail 355583 C57BL/6J ±  kb
transcript OTTMUST00000037929 VEGA | MGI Sequence Detail 5217 Not Applicable 
polypeptide OTTMUSP00000017026 VEGA | MGI Sequence Detail 1175 Not Applicable 

For the selected sequences
All sequences(121) RefSeq(34) UniProt(8)
Polymorphisms RFLP(2) : SNPs within 2kb(2064 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR011992 EF-hand-like domain
InterPro IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
InterPro IPR009535 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta, conserved site
InterPro IPR001192 Phosphoinositide phospholipase C
InterPro IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
InterPro IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
InterPro IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
InterPro IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000012831 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
References (Earliest) J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
(Latest) J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39
All references(71)
Other
accession IDs
MGD-MRK-35936, MGI:1925078, MGI:2139106, MGI:2443533

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory