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Plcb4
Gene Detail
Symbol

Name
ID
Plcb4
phospholipase C, beta 4
MGI:107464
Synonyms
A930039J07Rik, C230058B11Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
66.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:135659011-136014593 bp, + strand
From VEGA annotation of GRCm38

  355583 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8471  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLCB4
Protein SuperFamily: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta
Gene Tree: Plcb4

Human
homologs
PLCB4, phospholipase C, beta 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5332
neXtProt AC: NX_Q15147

Human Synonyms: ARCND2, PI-PLC

Human Chr (Location): 20p12; chr20:9068710-9480816 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PLCB4

Mutations,
alleles, and
phenotypes
All mutations/alleles(115) : Gene trapped(108) Radiation induced(1) Targeted(6)
Genomic Mutations involving Plcb4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations may exhibit ataxia, impaired elimination of excess climbing fiber synapses in the developing cerebellum, abnormal cerebellar foliation, reduced visual processing ability and loss of circadian rhythm in constant darkness.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Plcb4 interacts with 343 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process negative regulation of potassium ion transport
Component cytoplasm, dendrite, ...
Function mitogen-activated protein kinase binding, phosphatidylinositol phospholipase C activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (203)    Tissues (129)    Images (57)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 86
RNA in situ 117
cDNA source data(65)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase plcb4    NEW 
Molecular
reagents
All nucleic(69) cDNA(67) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000015959 (Evidence)
Ensembl Gene Model ENSMUSG00000039943 (Evidence)
Entrez Gene 18798 (Evidence)
UniGene 38009
DFCI TC1595369, TC1598899, TC1600969, TC1603214, TC1611691, TC1612196, TC1619529, TC1622059
DoTS DT.101370775, DT.101735851, DT.103566167, DT.488760, DT.87025407, DT.91289211, DT.91304823, DT.91323391, DT.91334166, DT.91422355
NIA Mouse Gene Index U002527
EC 3.1.4.11
Consensus CDS Project CCDS16788.1
International Mouse Phenotyping Consortium Status Plcb4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015959 VEGA Gene Model | MGI Sequence Detail 355583 C57BL/6J ±  kb
transcript OTTMUST00000037929 VEGA | MGI Sequence Detail 5217 Not Applicable 
polypeptide OTTMUSP00000017026 VEGA | MGI Sequence Detail 1175 Not Applicable 

For the selected sequences
All sequences(125) RefSeq(38) UniProt(8)
Polymorphisms
RFLP(2) : SNPs within 2kb(2064 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 domain
InterPro IPR011992 EF-hand domain pair
InterPro IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
InterPro IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
InterPro IPR001192 Phosphoinositide phospholipase C family
InterPro IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
InterPro IPR009535 Phospholipase C-beta, conserved site
InterPro IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
InterPro IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
InterPro IPR011993 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Protein Ontology PR:000012831 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
References
(Earliest) J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
(Latest) J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39
All references(70)
Other
accession IDs
MGD-MRK-35936, MGI:1925078, MGI:2139106, MGI:2443533

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory