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Irak1 Gene Detail
Summary
  • Symbol
    Irak1
  • Name
    interleukin-1 receptor-associated kinase 1
  • Synonyms
    Il1rak, IRAK-1, mPLK, Plpk
  • Feature Type
    protein coding gene
  • IDs
    MGI:107420
    NCBI Gene: 16179
  • Gene Overview
    MyGene.info: IRAK1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:74013914-74023918 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 37.61 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107420
protein coding gene ChrX:74013914-74023921 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035829
protein coding gene ChrX:69798447-69809153 (-)
A/J MGP_AJ_G0035810
protein coding gene ChrX:69992124-70002977 (-)
AKR/J MGP_AKRJ_G0035735
protein coding gene ChrX:71847647-71858110 (-)
BALB/cJ MGP_BALBcJ_G0035795
protein coding gene ChrX:69018038-69028007 (-)
C3H/HeJ MGP_C3HHeJ_G0035500
protein coding gene ChrX:70273784-70283888 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036325
protein coding gene ChrX:71950865-71960857 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033169
protein coding gene ChrX:69019264-69029057 (-)
CAST/EiJ MGP_CASTEiJ_G0034791
protein coding gene ChrX:55628805-55639776 (-)
CBA/J MGP_CBAJ_G0035475
protein coding gene ChrX:73945172-73955174 (-)
DBA/2J MGP_DBA2J_G0035632
protein coding gene ChrX:69445870-69455912 (-)
FVB/NJ MGP_FVBNJ_G0035576
protein coding gene ChrX:68785913-68795603 (-)
LP/J MGP_LPJ_G0035717
protein coding gene ChrX:70581463-70591453 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035614
protein coding gene ChrX:76503499-76513499 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036347
protein coding gene ChrX:69624000-69635574 (-)
PWK/PhJ MGP_PWKPhJ_G0034490
protein coding gene ChrX:53630344-53641710 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034324
protein coding gene ChrX:56521458-56533924 (-)
WSB/EiJ MGP_WSBEiJ_G0034932
protein coding gene ChrX:68892810-68903587 (-)



Homology
more
  • Human Ortholog
    IRAK1, interleukin 1 receptor associated kinase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IRAK1, interleukin 1 receptor associated kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IRAK, pelle
  • Links
    NCBI Gene ID: 3654
    neXtProt AC: NX_P51617
    UniProt: P51617

  • Chr Location
    Xq28; chrX:154010506-154019906 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 4 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an essentially normal phenotype. Cytokine production and response to endotoxin are attenuated however.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031392 Ensembl Gene Model | MGI Sequence Detail 10005 C57BL/6J ±  kb
transcript ENSMUST00000033769 Ensembl | MGI Sequence Detail 2890 Not Applicable  
polypeptide ENSMUSP00000033769 Ensembl | MGI Sequence Detail 750 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 123
    Genomic 3
    cDNA 119
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-35890, MGI:2147821
References
more
  • Summaries
    All 111
    Developmental Gene Expression 5
    Gene Ontology 23
    Phenotypes 40
  • Earliest
    J:34345 Trofimova M, et al., Developmental and tissue-specific expression of mouse pelle-like protein kinase. J Biol Chem. 1996 Jul 26;271(30):17609-12
  • Latest
    J:251197 Kong F, et al., Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages. J Immunol. 2017 Nov 15;199(10):3654-3667

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory