Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables interleukin-1 receptor binding activity and protein kinase activity. Involved in several processes, including interleukin-1-mediated signaling pathway; negative regulation of DNA-templated transcription; and negative regulation of cholesterol efflux. Acts upstream of or within cell surface receptor signaling pathway and response to peptidoglycan. Located in lipid droplet and membrane. Part of protein-containing complex. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1).