GO Annotations Graph

• Symbol: Irak1
• Name: interleukin-1 receptor-associated kinase 1
• ID: MGI:107420

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005149	interleukin-1 receptor binding	IPI	J:93342
Molecular Function	GO:0016301	kinase activity	ISO	J:73065
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:79541
Molecular Function	GO:0005515	protein binding	IPI	J:64697
Molecular Function	GO:0005515	protein binding	IPI	J:171920
Molecular Function	GO:0005515	protein binding	IPI	J:180054
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:169840
Molecular Function	GO:0005515	protein binding	IPI	J:113963
Molecular Function	GO:0005515	protein binding	IPI	J:208867
Molecular Function	GO:0005515	protein binding	IPI	J:67984
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:155856
Molecular Function	GO:0004672	protein kinase activity	IDA	J:77382
Molecular Function	GO:0004672	protein kinase activity	IDA	J:76115
Molecular Function	GO:0004672	protein kinase activity	ISO	J:73065
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9615830
Cellular Component	GO:0005811	lipid droplet	IDA	J:169840
Cellular Component	GO:0016020	membrane	IDA	J:116495
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	IDA	J:64697
Biological Process	GO:0007250	activation of NF-kappaB-inducing kinase activity	ISO	J:164563
Biological Process	GO:0034605	cellular response to heat	ISO	J:155856
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:93342
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEP	J:116495
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IDA	J:64697
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IDA	J:77382
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0007254	JNK cascade	ISO	J:155856
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IDA	J:84679
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IDA	J:76115
Biological Process	GO:0090370	negative regulation of cholesterol efflux	IMP	J:154929
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:154929
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:73065
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IMP	J:148060
Biological Process	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	ISO	J:164563
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IMP	J:148060
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IBA	J:265628
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IBA	J:265628
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	J:77382
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0032481	positive regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:76115
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:73065
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:77382
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0001959	regulation of cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070555	response to interleukin-1	ISO	J:164563
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:76115
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:84679
Biological Process	GO:0032494	response to peptidoglycan	IDA	J:76115
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0034134	toll-like receptor 2 signaling pathway	ISO	J:164563
Biological Process	GO:0034134	toll-like receptor 2 signaling pathway	IDA	J:76115
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	IBA	J:265628
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	IDA	J:76115
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	ISO	J:164563