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Lefty1 Gene Detail
Summary
  • Symbol
    Lefty1
  • Name
    left right determination factor 1
  • Synonyms
    Ebaf, Lefty, lefty-1, Stra3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107405
    NCBI Gene: 13590
Location & Maps
more
  • Sequence Map
    Chr1:180935022-180938400 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3379 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 84.46 cM, cytoband F
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    LEFTY1, left-right determination factor 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    LEFTY1, left-right determination factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LEFTB, LEFTYB
  • Links
    NCBI Gene ID: 10637
    neXtProt AC: NX_O75610

  • Chr Location
    1q42.1; chr1:225886282-225889146 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 3 genetic backgrounds
    23 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    30
  • Chemically induced (other)
    2
  • Gene trapped
    21
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    2 involving Lefty1
  • Incidental Mutations
Mice homozygous for a null allele show embryonic and postnatal lethality, abnormal liver lobation, and a variety of left-right positional defects in visceral organs including left thoracic and atrial isomerism. A subset of mice homozygous for a differentnull allele show left pulmonary isomerism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021473 VEGA Gene Model | MGI Sequence Detail 3379 C57BL/6J ±  kb
transcript OTTMUST00000050907 VEGA | MGI Sequence Detail 1620 Not Applicable  
polypeptide OTTMUSP00000023876 VEGA | MGI Sequence Detail 368 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    106 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR029034 Cystine-knot cytokine
    IPR003942 Left- Right determination factor
    IPR017948 Transforming growth factor beta, conserved site
    IPR001839 Transforming growth factor-beta, C-terminal
    IPR001111 Transforming growth factor-beta, N-terminal
    IPR015615 Transforming growth factor-beta-related
Molecular
Reagents
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  • All nucleic 47
    Genomic 7
    cDNA 27
    Primer pair 2
    Other 11

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-35873, MGD-MRK-36501, MGI:107921, MGI:2138250
References
more
  • Summaries
    All 176
    Developmental Gene Expression 131
    Gene Ontology 7
    Phenotypes 22
  • Earliest
    J:31593 Cereghini S, et al., Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles. Development. 1992 Nov;116(3):783-97
  • Latest
    J:229516 Qiu Z, et al., Ino80 is essential for proximal-distal axis asymmetry in part by regulating Bmp4 expression. BMC Biol. 2016;14(1):18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory