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Lefty1
Gene Detail
 Symbol
Name
ID
Lefty1
left right determination factor 1
MGI:107405
Synonyms Ebaf, Lefty, lefty-1, Stra3
Feature Type protein coding gene
Genetic Map
Chromosome 1
84.46 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:180935022-180938400 bp, + strand
From VEGA annotation of GRCm38

  3379 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49231  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: lefty protein
Gene Tree: Lefty1

Human
homologs
Human Homolog LEFTY1, left-right determination factor 1
NCBI Gene ID 10637
neXtProt AC  NX_O75610
Human Synonyms  LEFTB, LEFTYB
Human Chr (Location)  1q42.1; chr1:225886282-225889146 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(21) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele show embryonic and postnatal lethality, abnormal liver lobation, and a variety of left-right positional defects in visceral organs including left thoracic and atrial isomerism. A subset of mice homozygous for a different null allele show left pulmonary isomerism.
 
Interactions
Lefty1 interacts with 107 markers (Mir16-1, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process anterior/posterior axis specification, cell growth, ...
Component extracellular region, extracellular space
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (120 records)
Data Summary: Results (235)    Tissues (64)    Images (74)
Theiler Stages: 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 20, 21, 22, 23, 24, 25, 27, 28
Assay TypeResults
RNA in situ 192
RT-PCR 43
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) Genomic(7) cDNA(27) Primer pair(2) Other(11)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021473 (Evidence)
Ensembl Gene ModelENSMUSG00000038793 (Evidence)
Entrez Gene13590 (Evidence)
UniGene378911
DFCITC1581841
DoTSDT.488546
NIA Mouse Gene IndexU293332
Consensus CDS ProjectCCDS15577.1
International Mouse Knockout Project StatusLefty1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021473 VEGA Gene Model | MGI Sequence Detail 3379 C57BL/6J ±  kb
transcript OTTMUST00000050907 VEGA | MGI Sequence Detail 1620 Not Applicable 
polypeptide OTTMUSP00000023876 VEGA | MGI Sequence Detail 368 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003942 Left- Right determination factor
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000287 lefty 1
References (Earliest) J:31593 Cereghini S, et al., Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles. Development. 1992 Nov;116(3):783-97
(Latest) J:202883 Cai W, et al., Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment. Genes Dev. 2013 Nov 1;27(21):2332-44
All references(168)
Other
accession IDs
MGD-MRK-35873, MGD-MRK-36501, MGI:107921, MGI:2138250

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory