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Dnm1 Gene Detail
Summary
  • Symbol
    Dnm1
  • Name
    dynamin 1
  • Synonyms
    dynamin 1, Ftfl
  • Feature Type
    protein coding gene
  • IDs
    MGI:107384
    NCBI Gene: 13429
  • Gene Overview
    MyGene.info: DNM1
Location & Maps
more
  • Sequence Map
    Chr2:32308471-32353338 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      44868 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.09 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DNM1, dynamin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DNM1, dynamin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DNM, EIEE31
  • Links
    NCBI Gene ID: 1759
    neXtProt AC: NX_Q05193

  • Chr Location
    9q34; chr9:128203355-128255249 (+)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with Dnm1 mouse models; 1 with human DNM1 associations

Human Disease Mouse Models
       Epilepsy, Idiopathic Generalized; EIG   OMIM: 600669 View 1 model
       Epileptic Encephalopathy, Early Infantile, 31; EIEE31   OMIM: 616346
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 4 alleles in 6 genetic backgrounds
    13 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    4
  • Incidental Mutations
    Mutagenetix , APF
Homozygous mice display reduced postnatal viability. Null mutation of this gene results in abnormal synaptic vesicle morphology, and recycling during neuronal activity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    60
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    39
  • Tissues
    3
  • cDNA Data
    13
  • Literature Summary
    9
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012945 VEGA Gene Model | MGI Sequence Detail 44868 C57BL/6J ±  kb
transcript OTTMUST00000031099 VEGA | MGI Sequence Detail 3337 Not Applicable  
polypeptide OTTMUSP00000041061 VEGA | MGI Sequence Detail 867 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    65 from dbSNP Build 142
  • RFLP
    1
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-35851, MGI:2139061, MGI:3027061
References
more
  • Summaries
    All 84
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 19
    Phenotypes 23
  • Earliest
    J:33098 Gautam M, et al., Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996 May 17;85(4):525-35
  • Latest
    J:234091 Fan F, et al., Dynamin 1- and 3-Mediated Endocytosis Is Essential for the Development of a Large Central Synapse In Vivo. J Neurosci. 2016 Jun 1;36(22):6097-115
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory