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Dnm1
Gene Detail
Symbol

Name
ID
Dnm1
dynamin 1
MGI:107384
Synonyms
dynamin 1, Ftfl
Feature Type
protein coding gene
Genetic Map
Chromosome 2
22.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:32308471-32353329 bp, - strand
From VEGA annotation of GRCm38

  44859 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:123905  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: DNM1
Protein SuperFamily: dynamin, metazoan type
Gene Tree: Dnm1

Human
homologs
DNM1, dynamin 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1759
neXtProt AC: NX_Q05193

Human Synonyms: DNM, EIEE31

Human Chr (Location): 9q34; chr9:128203355-128255249 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DNM1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice display reduced postnatal viability. Null mutation of this gene results in abnormal synaptic vesicle morphology, and recycling during neuronal activity.
 
Human Diseases Modeled in Mice Using Dnm1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Dnm1 interacts with 282 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process adult locomotory behavior, clathrin-mediated endocytosis, ...
Component cytoplasm, cytoskeleton, ...
Function D2 dopamine receptor binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (39)    Tissues (3)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 27
RT-PCR 12
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dnm1    NEW 
Molecular
reagents
All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000012945 (Evidence)
Ensembl Gene Model ENSMUSG00000026825 (Evidence)
Entrez Gene 13429 (Evidence)
DFCI TC1595204, TC1577423, TC1694016, TC1603073, TC1597887
DoTS DT.110740986, DT.101381096, DT.101733884, DT.101381095, DT.55100126, DT.60104591, DT.97369571, DT.97369573
NIA Mouse Gene Index U022500
EC 3.6.5.5
Consensus CDS Project CCDS38102.1
International Mouse Phenotyping Consortium Status Dnm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012945 VEGA Gene Model | MGI Sequence Detail 44859 C57BL/6J ±  kb
transcript OTTMUST00000031099 VEGA | MGI Sequence Detail 3383 Not Applicable 
polypeptide OTTMUSP00000041061 VEGA | MGI Sequence Detail 867 Not Applicable 

For the selected sequences
All sequences(121) RefSeq(32) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022812 Dynamin
InterPro IPR000375 Dynamin central domain
InterPro IPR001401 Dynamin, GTPase domain
InterPro IPR003130 Dynamin GTPase effector
InterPro IPR019762 Dynamin, GTPase region, conserved site
InterPro IPR020850 GTPase effector domain, GED
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000006601 dynamin-1
References
(Earliest) J:33098 Gautam M, et al., Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996 May 17;85(4):525-35
(Latest) J:215304 Vargas KJ, et al., Synucleins regulate the kinetics of synaptic vesicle endocytosis. J Neurosci. 2014 Jul 9;34(28):9364-76
All references(77)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35851, MGI:2139061, MGI:3027061

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory