Dnm1
Gene Detail

Symbol Name ID

Dnm1 dynamin 1 MGI:107384

Synonyms

dynamin 1, Ftfl

Feature Type

protein coding gene

Genetic Map

Chromosome 2

22.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:32308471-32353329 bp, - strand From VEGA annotation of GRCm38   44859 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:123905  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: dynamin, metazoan type
Gene Tree: Dnm1

Human homologs

Human Homolog		DNM1, dynamin 1
NCBI Gene ID		1759
neXtProt AC		NX_Q05193
Human Synonyms		DNM
Human Chr (Location)		9q34; chr9:128203355-128255249 (+)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(5) : Gene trapped(1) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mice display reduced postnatal viability. Null mutation of this gene results in abnormal synaptic vesicle morphology, and recycling during neuronal activity.

 
Human Diseases Modeled Using Mouse Dnm1 (1)    Alleles Annotated to Human Diseases(1)   

Interactions

Dnm1 interacts with 282 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	endocytosis, endosome organization, ...
Component	cytoplasm, cytoskeleton, ...
Function	GTPase activity, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)

Data Summary: Results (39)    Tissues (2)    Images (5)
Theiler Stages: 25, 28

Assay Type	Results
Western blot	27
RT-PCR	12

cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(9) cDNA(8) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000012945 (Evidence)
Ensembl Gene Model	ENSMUSG00000026825 (Evidence)
Entrez Gene	13429 (Evidence)
DFCI	TC1577423, TC1595204, TC1597887, TC1603073, TC1694016
DoTS	DT.101381096, DT.101733884, DT.55100126, DT.60104591, DT.97369571, DT.97369573
NIA Mouse Gene Index	U022500
EC	3.6.5.5
Consensus CDS Project	CCDS38102.1
International Mouse Knockout Project Status	Dnm1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012945	VEGA Gene Model | MGI Sequence Detail	44859	C57BL/6J
transcript	OTTMUST00000031099	VEGA | MGI Sequence Detail	3383	Not Applicable
polypeptide	OTTMUSP00000041061	VEGA | MGI Sequence Detail	867	Not Applicable

All sequences(114) RefSeq(35) UniProt(5)

Polymorphisms

RFLP(1) : SNPs within 2kb(61 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR022812	Dynamin
InterPro	IPR000375	Dynamin central domain
InterPro	IPR001401	Dynamin, GTPase domain
InterPro	IPR003130	Dynamin GTPase effector
InterPro	IPR019762	Dynamin, GTPase region, conserved site
InterPro	IPR020850	GTPase effector domain, GED
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Protein Ontology	PR:000006601	dynamin-1

References

(Earliest) J:33098 Gautam M, et al., Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996 May 17;85(4):525-35
(Latest) J:209576 Piccoli G, et al., Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain. Mol Cell Biol. 2014 Jun 15;34(12):2147-2161
All references(74)
Disease annotation references (1)

Other accession IDs

MGD-MRK-35851, MGI:2139061, MGI:3027061