About   Help   FAQ
Dnm1
Gene Detail
 Symbol
Name
ID
Dnm1
dynamin 1
MGI:107384
Synonyms dynamin 1, Ftfl
Feature Type protein coding gene
Genetic Map
Chromosome 2
22.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:32308471-32353329 bp, - strand
From VEGA annotation of GRCm38

  44859 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:123905  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: dynamin, metazoan type
Gene Tree: Dnm1

Human
homologs
Human Homolog DNM1, dynamin 1
NCBI Gene ID 1759
neXtProt AC  NX_Q05193
Human Synonyms  DNM
Human Chr (Location)  9q34; chr9:128203355-128255249 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice display reduced postnatal viability. Null mutation of this gene results in abnormal synaptic vesicle morphology, and recycling during neuronal activity.
 
Human Diseases Modeled Using Mouse Dnm1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Dnm1 interacts with 282 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process endocytosis, endosome organization, ...
Component cytoplasm, cytoskeleton, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (39)    Tissues (2)    Images (5)
Theiler Stages: 25, 28
Assay TypeResults
Western blot 27
RT-PCR 12
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(8) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000012945 (Evidence)
Ensembl Gene ModelENSMUSG00000026825 (Evidence)
Entrez Gene13429 (Evidence)
DFCITC1577423, TC1595204, TC1597887, TC1603073, TC1694016
DoTSDT.101381096, DT.101733884, DT.55100126, DT.60104591, DT.97369571, DT.97369573
NIA Mouse Gene IndexU022500
EC3.6.5.5
Consensus CDS ProjectCCDS38102.1
International Mouse Knockout Project StatusDnm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012945 VEGA Gene Model | MGI Sequence Detail 44859 C57BL/6J ±  kb
transcript OTTMUST00000031099 VEGA | MGI Sequence Detail 3383 Not Applicable 
polypeptide OTTMUSP00000041061 VEGA | MGI Sequence Detail 867 Not Applicable 

For the selected sequences
All sequences(114) RefSeq(35) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022812 Dynamin
InterPro IPR000375 Dynamin central domain
InterPro IPR001401 Dynamin, GTPase domain
InterPro IPR003130 Dynamin GTPase effector
InterPro IPR019762 Dynamin, GTPase region, conserved site
InterPro IPR020850 GTPase effector domain, GED
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000006601 dynamin-1
References (Earliest) J:33098 Gautam M, et al., Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996 May 17;85(4):525-35
(Latest) J:209576 Piccoli G, et al., Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain. Mol Cell Biol. 2014 Jun 15;34(12):2147-2161
All references(74)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35851, MGI:2139061, MGI:3027061

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory