Dnm1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dnm1
dynamin 1
MGI:107384

16 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Dnm1^tm1.2Frk/Dnm1^tm1.2Frk B6.129(Cg)-Dnm1^tm1.2Frk	normal nervous system phenotype	J:235711
Dnm1^tm1Frk/Dnm1⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * CBA * FVB/NJ	normal behavior/neurological phenotype	J:373297
	postnatal growth retardation	J:373297
	postnatal lethality, incomplete penetrance	J:373297
Dnm1^tm1Frk/Dnm1⁺ Pvalb^tm1(cre)Arbr/Pvalb⁺ involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac * FVB/NJ	normal growth/size/body region phenotype	J:373297
	premature death	J:373297
	seizures	J:373297
Dnm1^tm1Frk/Dnm1⁺ Tg(Nkx2-1-cre)2Sand/0 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB/NJ	normal growth/size/body region phenotype	J:373297
Dnm1^tm1Pdc/Dnm1^tm1Pdc Dnm2^tm1.1Pdc/Dnm2^tm1.1Pdc involves: 129S1/SvImJ * C57BL/6 * SJL	abnormal cell physiology	J:161127
Dnm1^tm1Pdc/Dnm1^tm1Pdc Dnm3^tm1.2Pdc/Dnm3^tm1.2Pdc involves: 129S1/Sv * C57BL/6 * FVB/N	abnormal miniature excitatory postsynaptic currents	J:175247
	abnormal synaptic vesicle morphology	J:175247
	abnormal synaptic vesicle number	J:175247
	abnormal synaptic vesicle recycling	J:175247
	abnormal voluntary movement	J:175247
	absent gastric milk in neonates	J:175247
	cyanosis	J:175247
	decreased excitatory postsynaptic current amplitude	J:175247
	hunched posture	J:175247
	neonatal lethality, complete penetrance	J:175247
Dnm1^tm2.1Pdc/Dnm1^tm2.1Pdc Dnm2^tm1.1Pdc/Dnm2^tm1.1Pdc Kdr^tm2.1Jrt/Kdr^tm2.1Jrt Tg(Pax6-cre,GFP)2Pgr/0 involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6	abnormal retina vasculature morphology	J:217533
Dnm1^tm2.1Pdc/Dnm1^tm2.1Pdc Dnm2^tm1.1Pdc/Dnm2^tm1.1Pdc Tg(Pax6-cre,GFP)2Pgr/0 involves: 129S1/SvImJ * C57BL/6	abnormal retina neuronal layer morphology	J:217533
	abnormal retina vasculature morphology	J:217533
Dnm1^tm2.2Frk/Dnm1^tm2.2Frk B6.129(Cg)-Dnm1^tm2.2Frk	normal nervous system phenotype	J:235711

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29