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Ube2i
Gene Detail
 Symbol
Name
ID
Ube2i
ubiquitin-conjugating enzyme E2I
MGI:107365
Synonyms 5830467E05Rik, Mmubc9, UBC9, Ubce9
Feature Type protein coding gene
Genetic Map
Chromosome 17
12.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:25261916-25274622 bp, - strand
From VEGA annotation of GRCm38

  12707 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5574  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ubiquitin-conjugating enzyme E2
Gene Tree: Ube2i

Human
homologs
Human Homolog UBE2I, ubiquitin-conjugating enzyme E2I
NCBI Gene ID 7329
neXtProt AC  NX_P63279
Human Synonyms  C358B7.1, P18, UBC9
Human Chr (Location)  16p13.3; chr16:1309153-1327018 (+)  GRCh38
Alleles
and
phenotypes
All alleles(25) : Gene trapped(23) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a targeted null mutation die prior to E7.5. In culture, mutant blastocysts are viable up to 2 days but show subsequent apoptosis of the inner cell mass. Mutant cells exhibit major chromosome condensation and segregation defects as well as gross defects in nuclear organization.
 
Gene Ontology
(GO)
classifications
All GO classifications: (54 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, dendrite, ...
Function acid-amino acid ligase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (8)    Tissues (7)   
Theiler Stages: 1, 2, 3, 4, 28
Assay TypeResults
Immunohistochemistry 8
cDNA source data(37)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(38) Genomic(1) cDNA(37)
Microarray probesets(12)
Other database
links
VEGA Gene ModelOTTMUSG00000037656 (Evidence)
Ensembl Gene ModelENSMUSG00000015120 (Evidence)
Entrez Gene22196 (Evidence)
DFCITC1573910, TC1580316, TC1599272, TC1613530, TC1630812, TC1733251
DoTSDT.101405474, DT.101405478, DT.101405491, DT.103575320, DT.110578317, DT.110578340, DT.528079, DT.537369, DT.91360096, DT.97388528, DT.99868625
EC6.3.2.-
PDB1U9A, 1U9B, 2UYZ, 2VRR
Consensus CDS ProjectCCDS28513.1
International Mouse Knockout Project StatusUbe2i
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037656 VEGA Gene Model | MGI Sequence Detail 12707 C57BL/6J ±  kb
transcript OTTMUST00000097202 VEGA | MGI Sequence Detail 1138 Not Applicable 
polypeptide OTTMUSP00000054462 VEGA | MGI Sequence Detail 158 Not Applicable 

For the selected sequences
All sequences(140) RefSeq(14) UniProt(6)
Polymorphisms SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027230 SUMO-conjugating enzyme Ubc9
InterPro IPR023313 Ubiquitin-conjugating enzyme, active site
InterPro IPR000608 Ubiquitin-conjugating enzyme, E2
InterPro IPR016135 Ubiquitin-conjugating enzyme/RWD-like
Protein Ontology PR:000016977 SUMO-conjugating enzyme UBC9
References (Earliest) J:32204 Kovalenko OV, et al., Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2958-63
(Latest) J:183253 Yukita A, et al., Ubc9 negatively regulates BMP-mediated osteoblastic differentiation in cultured cells. Bone. 2012 May;50(5):1092-9
All references(59)
Other
accession IDs
MGD-MRK-35832, MGI:1923335

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory