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Ube2i
Gene Detail
Symbol

Name
ID
Ube2i
ubiquitin-conjugating enzyme E2I
MGI:107365
Synonyms
5830467E05Rik, Mmubc9, UBC9, Ubce9
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:25261916-25274622 bp, - strand
From VEGA annotation of GRCm38

  12707 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5574  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UBE2I
Protein SuperFamily: ubiquitin-conjugating enzyme E2
Gene Tree: Ube2i

Human
homologs
UBE2I, ubiquitin-conjugating enzyme E2I
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7329
neXtProt AC: NX_P63279

Human Synonyms: C358B7.1, P18, UBC9

Human Chr (Location): 16p13.3; chr16:1309153-1327018 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(23) Radiation induced(2) Targeted(2)
Genomic Mutations involving Ube2i (2)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a targeted null mutation die prior to E7.5. In culture, mutant blastocysts are viable up to 2 days but show subsequent apoptosis of the inner cell mass. Mutant cells exhibit major chromosome condensation and segregation defects as well as gross defects in nuclear organization.
 
Interactions
Ube2i interacts with 240 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (64 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, dendrite, ...
Function ATP binding, bHLH transcription factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (8)    Tissues (7)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
cDNA source data(37)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ube2i ; ZFIN ube2ia, ube2ib    NEW 
Molecular
reagents
All nucleic(38) Genomic(1) cDNA(37)
Microarray probesets(12)
Other database
links
VEGA Gene Model OTTMUSG00000037656 (Evidence)
Ensembl Gene Model ENSMUSG00000015120 (Evidence)
Entrez Gene 22196 (Evidence)
DFCI TC1573910, TC1580316, TC1599272, TC1613530, TC1630812, TC1733251
DoTS DT.101405474, DT.101405478, DT.101405491, DT.103575320, DT.110578317, DT.110578340, DT.528079, DT.537369, DT.91360096, DT.97388528, DT.99868625
NIA Mouse Gene Index U037552, U040593, U068201
EC 6.3.2.-
PDB 1U9A, 1U9B, 2UYZ, 2VRR
Consensus CDS Project CCDS28513.1
International Mouse Phenotyping Consortium Status Ube2i
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037656 VEGA Gene Model | MGI Sequence Detail 12707 C57BL/6J ±  kb
transcript OTTMUST00000097202 VEGA | MGI Sequence Detail 1138 Not Applicable 
polypeptide OTTMUSP00000054462 VEGA | MGI Sequence Detail 158 Not Applicable 

For the selected sequences
All sequences(139) RefSeq(10) UniProt(6)
Polymorphisms
SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027230 SUMO-conjugating enzyme Ubc9
InterPro IPR023313 Ubiquitin-conjugating enzyme, active site
InterPro IPR000608 Ubiquitin-conjugating enzyme E2
InterPro IPR016135 Ubiquitin-conjugating enzyme/RWD-like
Protein Ontology PR:000016977 SUMO-conjugating enzyme UBC9
References
(Earliest) J:32204 Kovalenko OV, et al., Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2958-63
(Latest) J:217093 Fritah S, et al., Sumoylation controls host anti-bacterial response to the gut invasive pathogen Shigella flexneri. EMBO Rep. 2014 Sep;15(9):965-72
All references(62)
Other
accession IDs
MGD-MRK-35832, MGI:1923335

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory