Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables HLH domain binding activity. Involved in negative regulation of transcription by RNA polymerase II and nuclear export. Acts upstream of or within positive regulation of canonical NF-kappaB signal transduction. Located in nuclear body. Part of SUMO ligase complex. Is expressed in several structures, including early embryo; forebrain; forelimb bud; limb; and oocyte. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I).