Ctse MGI Mouse Gene Detail - MGI:107361

Symbol

Ctse
Name

cathepsin E
Synonyms

A430072O03Rik, C920004C08Rik, CatE, CE

Feature Type

protein coding gene
IDs

MGI:107361
NCBI Gene: 13034
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr1:131566052-131603245 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 57.14 cM, cytoband F
Mapping Data

7 experiments

SNPs within 2kb

319 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107361	protein coding gene	Chr1:131566044-131603245 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016456	protein coding gene	Chr1:135080563-135108783 (+)
A/J	MGP_AJ_G0016439	protein coding gene	Chr1:130083959-130117394 (+)
AKR/J	MGP_AKRJ_G0016404	protein coding gene	Chr1:133910583-133938583 (+)
BALB/cJ	MGP_BALBcJ_G0016399	protein coding gene	Chr1:130411304-130440383 (+)
C3H/HeJ	MGP_C3HHeJ_G0016225	protein coding gene	Chr1:134050587-134085433 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016860	protein coding gene	Chr1:140099241-140135235 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014574	protein coding gene	Chr1:123218753-123247643 (+)
CAST/EiJ	MGP_CASTEiJ_G0015805	protein coding gene	Chr1:133047526-133077336 (+)
CBA/J	MGP_CBAJ_G0016197	protein coding gene	Chr1:144894495-144922462 (+)
DBA/2J	MGP_DBA2J_G0016304	protein coding gene	Chr1:129053441-129081312 (+)
FVB/NJ	MGP_FVBNJ_G0016303	protein coding gene	Chr1:127679359-127707137 (+)
LP/J	MGP_LPJ_G0016375	protein coding gene	Chr1:136388208-136419961 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016328	protein coding gene	Chr1:150656731-150701316 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016896	protein coding gene	Chr1:133661932-133690498 (+)
PWK/PhJ	MGP_PWKPhJ_G0015591	protein coding gene	Chr1:128009095-128038186 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015378	protein coding gene	Chr1:132613049-132641342 (+)
WSB/EiJ	MGP_WSBEiJ_G0015867	protein coding gene	Chr1:133653203-133681759 (+)

Human Ortholog

CTSE, cathepsin E

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTSE, cathepsin E
Synonyms

CATE
Links

HGNC:2530

NCBI Gene ID: 1510

neXtProt AC: NX_P14091

UniProt: P14091
Chr Location

1q32.1; chr1:206008535-206023909 (-) GRCh38

MGI Vertebrate Homology

Ctse stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CTSE
Gene Tree

Ctse

Diseases

1 with Ctse mouse models

Human Disease

Mouse Models

atopic dermatitis

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

18 phenotypes from 3 alleles in 3 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

3 involving Ctse
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted mutation are viable and fertile, but develop skin lesions on the face, ears, neck and dorsal skin which are similar to those seen in human atopic dermatitis.

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

895
Tissues

27
cDNA Data

45
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctse

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All Sequences

51
RefSeq

2
UniProt

2
CCDS

CCDS15271.1

Ensembl

ENSMUSG00000004552 (Evidence)
NCBI Gene

13034

			Length	Strain/Species	Flank
genomic	13034	NCBI Gene Model \| MGI Sequence Detail	37194	C57BL/6J	± kb
transcript	NM_007799	RefSeq \| MGI Sequence Detail	2120	ZRU/MplStud
polypeptide	P70269	UniProt \| EBI \| MGI Sequence Detail	397	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006026 cathepsin E

(term hierarchy)
EC

3.4.23.34, 3.4.24.34
InterPro Domains

IPR001461 Aspartic peptidase A1 family

IPR001969 Aspartic peptidase, active site

IPR021109 Aspartic peptidase domain superfamily

IPR012848 Aspartic peptidase, N-terminal

IPR033121 Peptidase family A1 domain

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All nucleic 50

Genomic 2

cDNA 46

Primer pair 2

Microarray probesets 5

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MGD-MRK-35827, MGI:2441798, MGI:2441925

Summaries

All 73

Developmental Gene Expression 8

Diseases 1

Gene Ontology 7

Phenotypes 23
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Ctse:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8635	Chr1:131566008-131566034 (+)	-31 bp
Tssr8636	Chr1:131566044-131566076 (+)	8 bp
Tssr8637	Chr1:131566092-131566101 (+)	45 bp
Tssr8638	Chr1:131566126-131566142 (+)	82 bp
Tssr8639	Chr1:131566178-131566222 (+)	148 bp
Tssr8640	Chr1:131566223-131566234 (+)	177 bp
Tssr8641	Chr1:131589606-131589617 (+)	23,560 bp
Tssr8642	Chr1:131589641-131589677 (+)	23,607 bp
Tssr8643	Chr1:131589686-131589712 (+)	23,647 bp
Tssr8644	Chr1:131600000-131600015 (+)	33,956 bp
Tssr8645	Chr1:131600019-131600032 (+)	33,974 bp
Tssr8646	Chr1:131602598-131602614 (+)	36,554 bp
Tssr8647	Chr1:131602654-131602676 (+)	36,613 bp
Tssr8648	Chr1:131602683-131602698 (+)	36,639 bp
Tssr8649	Chr1:131602768-131602796 (+)	36,730 bp
Tssr8650	Chr1:131602814-131602824 (+)	36,767 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23