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Ctse
Gene Detail
 Symbol
Name
ID
Ctse
cathepsin E
MGI:107361
Synonyms A430072O03Rik, C920004C08Rik, CatE, CE
Feature Type protein coding gene
Genetic Map
Chromosome 1
57.14 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr1:131638306-131675505 bp, + strand
From VEGA annotation of GRCm38

  37200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37551  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: Pepsin
Gene Tree: Ctse

Human
homologs
Human Homolog CTSE, cathepsin E
NCBI Gene ID 1510
neXtProt AC  NX_P14091
Human Synonyms  CATE
Human Chr (Location)  1q31; chr1:206009264-206023909 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation are viable and fertile, but develop skin lesions on the face, ears, neck and dorsal skin which are similar to those seen in human atopic dermatitis.
 
Human Diseases Modeled Using Mouse Ctse (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ctse interacts with 65 markers (Mir20a, Mir29a, Mir29b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process antigen processing and presentation of exogenous peptide antigen via MHC class II, protein autoprocessing, ...
Component endosome, extracellular vesicular exosome
Function aspartic-type endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (179)    Tissues (22)    Images (24)
Theiler Stages: 23
Assay TypeResults
RNA in situ 179
cDNA source data(43)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) Genomic(2) cDNA(44)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022661 (Evidence)
Ensembl Gene ModelENSMUSG00000004552 (Evidence)
Entrez Gene13034 (Evidence)
UniGene230249
DFCITC1576142, TC1599333, TC1610798
DoTSDT.483886, DT.91308976, DT.91386777, DT.94254660, DT.97370421
NIA Mouse Gene IndexU000782
EC3.4.24.34, 3.4.23.34
Consensus CDS ProjectCCDS15271.1
International Mouse Knockout Project StatusCtse
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022661 VEGA Gene Model | MGI Sequence Detail 37200 C57BL/6J ±  kb
transcript OTTMUST00000054295 VEGA | MGI Sequence Detail 2126 Not Applicable 
polypeptide OTTMUSP00000025900 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(2)
Polymorphisms RFLP(4) : SNPs within 2kb(324 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021109 Aspartic peptidase
InterPro IPR001461 Peptidase A1
InterPro IPR001969 Peptidase aspartic, active site
InterPro IPR012848 Propeptide, peptidase A1
Protein Ontology PR:000006026 cathepsin E
References (Earliest) J:10617 Couvreur JM, et al., Assignment of cathepsin E (CTSE) to human chromosome region 1q31 by in situ hybridization and analysis of somatic cell hybrids. Cytogenet Cell Genet. 1990;53(2-3):137-9
(Latest) J:208441 Bautista DM, et al., Why we scratch an itch: the molecules, cells and circuits of itch. Nat Neurosci. 2014 Feb;17(2):175-82
All references(56)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-35827, MGI:2441798, MGI:2441925

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory