Ctse
Gene Detail

Symbol Name ID

Ctse cathepsin E MGI:107361

Synonyms

A430072O03Rik, C920004C08Rik, CatE, CE

Feature Type

protein coding gene

Genetic Map

Chromosome 1

57.14 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr1:131638306-131675503 bp, + strand From VEGA annotation of GRCm38   37198 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37551  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: Pepsin
Gene Tree: Ctse

Human homologs

Human Homolog		CTSE, cathepsin E
NCBI Gene ID		1510
neXtProt AC		NX_P14091
Human Synonyms		CATE
Human Chr (Location)		1q31; chr1:206317459-206332104 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(3) Spontaneous(1) Other(1)
 

Mice homozygous for a targeted mutation are viable and fertile, but develop skin lesions on the face, ears, neck and dorsal skin which are similar to those seen in human atopic dermatitis.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	antigen processing and presentation of exogenous peptide antigen via MHC class II, metabolic process, ...
Component	endosome
Function	aspartic-type endopeptidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (179)    Tissues (22)    Images (24)
Theiler Stages: 23

Assay Type	Results
RNA in situ	179

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(44) Genomic(2) cDNA(42)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000022661 (Evidence)
Ensembl Gene Model	ENSMUSG00000004552 (Evidence)
Entrez Gene	13034 (Evidence)
UniGene	230249
DFCI	TC1576142, TC1599333, TC1610798
DoTS	DT.483886, DT.91308976, DT.91386777, DT.94254660, DT.97370421
NIA Mouse Gene Index	U000782
EC	3.4.24.34, 3.4.23.34
Consensus CDS Project	CCDS15271.1
International Mouse Knockout Project Status	Ctse

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022661	VEGA Gene Model | MGI Sequence Detail	37198	C57BL/6J
transcript	OTTMUST00000054295	VEGA | MGI Sequence Detail	2124	Not Applicable
polypeptide	OTTMUSP00000025900	VEGA | MGI Sequence Detail	397	Not Applicable

All sequences(48) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(4) : SNPs(264 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001461	Peptidase A1
InterPro	IPR021109	Peptidase aspartic
InterPro	IPR001969	Peptidase aspartic, active site
InterPro	IPR009007	Peptidase aspartic, catalytic
InterPro	IPR012848	Propeptide, peptidase A1
Protein Ontology	PR:000006026	cathepsin E

References

(Earliest) J:10617 Couvreur JM, et al., Assignment of cathepsin E (CTSE) to human chromosome region 1q31 by in situ hybridization and analysis of somatic cell hybrids. Cytogenet Cell Genet. 1990;53(2-3):137-9
(Latest) J:186666 Pang CJ, et al., Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis. Mol Cell Biol. 2012 Jul;32(13):2628-44
All references(53)

Other accession IDs

MGD-MRK-35827, MGI:2441798, MGI:2441925