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Ctse Gene Detail
Summary
  • Symbol
    Ctse
  • Name
    cathepsin E
  • Synonyms
    A430072O03Rik, C920004C08Rik, CatE, CE
  • Feature Type
    protein coding gene
  • IDs
    MGI:107361
    NCBI Gene: 13034
  • Gene Overview
    MyGene.info: CTSE
Location & Maps
more
  • Sequence Map
    Chr1:131638306-131675505 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37200 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 57.14 cM, cytoband F
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    CTSE, cathepsin E
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CTSE, cathepsin E
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CATE
  • Links
    NCBI Gene ID: 1510
    neXtProt AC: NX_P14091

  • Chr Location
    1q31; chr1:206009264-206023909 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Ctse mouse models

Human Disease Mouse Models
       Dermatitis, Atopic   OMIM: 603165 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Ctse
  • Incidental Mutations
Mice homozygous for a targeted mutation are viable and fertile, but develop skin lesions on the face, ears, neck and dorsal skin which are similar to those seen in human atopic dermatitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022661 VEGA Gene Model | MGI Sequence Detail 37200 C57BL/6J ±  kb
transcript OTTMUST00000054295 VEGA | MGI Sequence Detail 2126 Not Applicable  
polypeptide OTTMUSP00000025900 VEGA | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    319 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    Genomic 2
    cDNA 44

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-35827, MGI:2441798, MGI:2441925
References
more
  • Summaries
    All 57
    Developmental Gene Expression 3
    Diseases 3
    Gene Ontology 9
    Phenotypes 20
  • Earliest
    J:10617 Couvreur JM, et al., Assignment of cathepsin E (CTSE) to human chromosome region 1q31 by in situ hybridization and analysis of somatic cell hybrids. Cytogenet Cell Genet. 1990;53(2-3):137-9
  • Latest
    J:226407 Ni J, et al., The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage. J Neurosci. 2015 Sep 9;35(36):12488-501

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory