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Ctse
Gene Detail
Symbol

Name
ID
Ctse
cathepsin E
MGI:107361
Synonyms
A430072O03Rik, C920004C08Rik, CatE, CE
Feature Type
protein coding gene
Genetic Map
Chromosome 1
57.14 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr1:131638306-131675505 bp, + strand
From VEGA annotation of GRCm38

  37200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37551  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CTSE
Protein SuperFamily: Pepsin
Gene Tree: Ctse

Human
homologs
CTSE, cathepsin E
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1510
neXtProt AC: NX_P14091

Human Synonyms: CATE

Human Chr (Location): 1q31; chr1:206009264-206023909 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation are viable and fertile, but develop skin lesions on the face, ears, neck and dorsal skin which are similar to those seen in human atopic dermatitis.
 
Human Diseases Modeled in Mice Using Ctse (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Ctse interacts with 65 markers (Mir20a, Mir29a, Mir29b-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (179)    Tissues (22)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 179
cDNA source data(43)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ctse    NEW 
Molecular
reagents
All nucleic(46) Genomic(2) cDNA(44)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000022661 (Evidence)
Ensembl Gene Model ENSMUSG00000004552 (Evidence)
Entrez Gene 13034 (Evidence)
UniGene 230249
DFCI TC1599333, TC1576142, TC1610798
DoTS DT.483886, DT.91386777, DT.91308976, DT.94254660, DT.97370421
NIA Mouse Gene Index U000782
EC 3.4.24.34, 3.4.23.34
Consensus CDS Project CCDS15271.1
International Mouse Phenotyping Consortium Status Ctse
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022661 VEGA Gene Model | MGI Sequence Detail 37200 C57BL/6J ±  kb
transcript OTTMUST00000054295 VEGA | MGI Sequence Detail 2126 Not Applicable 
polypeptide OTTMUSP00000025900 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(4) : SNPs within 2kb(324 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021109 Aspartic peptidase
InterPro IPR001461 Peptidase A1
InterPro IPR001969 Peptidase aspartic, active site
InterPro IPR012848 Propeptide, peptidase A1
Protein Ontology PR:000006026 cathepsin E
References
(Earliest) J:10617 Couvreur JM, et al., Assignment of cathepsin E (CTSE) to human chromosome region 1q31 by in situ hybridization and analysis of somatic cell hybrids. Cytogenet Cell Genet. 1990;53(2-3):137-9
(Latest) J:219134 Kadowaki T, et al., Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet. Biochem Biophys Res Commun. 2014 Mar 28;446(1):212-7
All references(58)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-35827, MGI:2441798, MGI:2441925

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory