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Gfm1 Gene Detail
Summary
  • Symbol
    Gfm1
  • Name
    G elongation factor, mitochondrial 1
  • Synonyms
    D3Wsu133e
  • Feature Type
    protein coding gene
  • IDs
    MGI:107339
    NCBI Gene: 28030
  • Gene Overview
    MyGene.info: GFM1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:67430115-67475068 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 30.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    368 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107339
protein coding gene Chr3:67430096-67476529 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027280
protein coding gene Chr3:66586698-66633122 (+)
A/J MGP_AJ_G0027242
protein coding gene Chr3:64622368-64668794 (+)
AKR/J MGP_AKRJ_G0027210
protein coding gene Chr3:66015082-66065515 (+)
BALB/cJ MGP_BALBcJ_G0027253
protein coding gene Chr3:64497805-64544284 (+)
C3H/HeJ MGP_C3HHeJ_G0026997
protein coding gene Chr3:66259259-66305711 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027699
protein coding gene Chr3:69076134-69122558 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025052
protein coding gene Chr3:60956141-60999299 (+)
CAST/EiJ MGP_CASTEiJ_G0026444
protein coding gene Chr3:66205820-66253199 (+)
CBA/J MGP_CBAJ_G0026972
protein coding gene Chr3:71230527-71281390 (+)
DBA/2J MGP_DBA2J_G0027108
protein coding gene Chr3:64133583-64182531 (+)
FVB/NJ MGP_FVBNJ_G0027076
protein coding gene Chr3:62768518-62815446 (+)
LP/J MGP_LPJ_G0027216
protein coding gene Chr3:67509253-67555664 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027095
protein coding gene Chr3:75886054-75938396 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027757
protein coding gene Chr3:65895196-65941722 (+)
PWK/PhJ MGP_PWKPhJ_G0026178
protein coding gene Chr3:63873508-63920392 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025994
protein coding gene Chr3:64995138-65046364 (+)
WSB/EiJ MGP_WSBEiJ_G0026522
protein coding gene Chr3:66003745-66056071 (+)



Homology
more
  • Human Ortholog
    GFM1, G elongation factor mitochondrial 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GFM1, G elongation factor mitochondrial 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COXPD1, EFG, EFG1, EFGM, EGF1, GFM, hEFG1, mtEF-G1
  • Links
    NCBI Gene ID: 85476
    neXtProt AC: NX_Q96RP9
    UniProt: Q96RP9

  • Chr Location
    3q25.32; chr3:158644497-158692572 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human GFM1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 28030 NCBI Gene Model | MGI Sequence Detail 44954 C57BL/6J ±  kb
    transcript NM_138591 RefSeq | MGI Sequence Detail 2598 Not Specified  
    polypeptide Q8K0D5 UniProt | EBI | MGI Sequence Detail 751 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000007943 elongation factor G, mitochondrial
    • InterPro Domains
      IPR035647 EF-G domain III/V-like
      IPR035649 EFG, domain V
      IPR000640 Elongation factor EFG, domain V-like
      IPR009022 Elongation factor G, domain III
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR020568 Ribosomal protein S5 domain 2-type fold
      IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
      IPR005225 Small GTP-binding protein domain
      IPR000795 Transcription factor, GTP-binding domain
      IPR004540 Translation elongation factor EFG/EF2
      IPR005517 Translation elongation factor EFG/EF2, domain IV
      IPR004161 Translation elongation factor EFTu-like, domain 2
      IPR009000 Translation protein, beta-barrel domain superfamily
      IPR031157 Tr-type G domain, conserved site
    Molecular
    Reagents
    less
    • All nucleic 120
      cDNA 119
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35805, MGI:2139995
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory