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Gfm1 Gene Detail
Summary
  • Symbol
    Gfm1
  • Name
    G elongation factor, mitochondrial 1
  • Synonyms
    D3Wsu133e
  • Feature Type
    protein coding gene
  • IDs
    MGI:107339
    NCBI Gene: 28030
  • Gene Overview
    MyGene.info: GFM1
Location & Maps
more
  • Sequence Map
    Chr3:67430096-67476529 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46434 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 30.96 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GFM1, G elongation factor, mitochondrial 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GFM1, G elongation factor, mitochondrial 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    COXPD1, EFG, EFG1, EFGM, EGF1, GFM, hEFG1
  • Links
    NCBI Gene ID: 85476
    neXtProt AC: NX_Q96RP9

  • Chr Location
    3q25; chr3:158644497-158692572 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GFM1 associations

Human Disease Mouse Models
       Combined Oxidative Phosphorylation Deficiency 1; COXPD1   OMIM: 609060
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Gfm1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029074 VEGA Gene Model | MGI Sequence Detail 46434 C57BL/6J ±  kb
transcript OTTMUST00000072125 VEGA | MGI Sequence Detail 4078 Not Applicable  
polypeptide OTTMUSP00000037052 VEGA | MGI Sequence Detail 751 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    387 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007943 elongation factor G, mitochondrial
  • InterPro Domains
    IPR009022 Elongation factor G, III-V domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR020568 Ribosomal protein S5 domain 2-type fold
    IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
    IPR005225 Small GTP-binding protein domain
    IPR000795 Transcription factor, GTP-binding domain
    IPR004540 Translation elongation factor EFG/EF2
    IPR005517 Translation elongation factor EFG/EF2, domain IV
    IPR000640 Translation elongation factor EFG, V domain
    IPR004161 Translation elongation factor EFTu-like, domain 2
    IPR009000 Translation protein, beta-barrel domain
    IPR031157 Tr-type G domain, conserved site
Molecular
Reagents
less
  • All nucleic 119
    cDNA 118
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-35805, MGI:2139995
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory