Gfm1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gfm1
G elongation factor, mitochondrial 1
MGI:107339

24 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd4^{tm1(cre/ERT2)Thbu}/Cd4⁺ Gfm1^{tm1c(EUCOMM)Wtsi}/Gfm1^{tm1c(EUCOMM)Wtsi} involves: C57BL/6 * C57BL/6N * SJL	abnormal T-helper 17 cell differentiation	J:302272
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:302272
	increased CD8-positive, alpha-beta T cell number	J:302272
	increased single-positive T cell number	J:302272
Gfm1^em1Rmrt/Gfm1^em1Rmrt C57BL/6NTac-Gfm1^em1Rmrt	embryonic lethality between implantation and placentation, complete penetrance	J:361430
Gfm1^em1Rmrt/Gfm1^em1Rmrt C57BL/6NTac-Gfm1^em1Rmrt	embryonic lethality, complete penetrance	J:361430
Gfm1^em1Rmrt/Gfm1^em2Rmrt involves: C57BL/6J * C57BL/6NTac	abnormal mitochondrial ATP synthesis coupled electron transport	J:361430
	abnormal oxidative phosphorylation	J:361430
	decreased body weight	J:361430
	decreased cytochrome-c oxidase activity	J:361430
	decreased mitochondria enzyme/coenzyme activity	J:361430
	decreased protein level	J:361430
	impaired mitochondrial translation	J:361430
	increased brain enzyme/coenzyme activity	J:361430
	increased mitochondrial fission	J:361430
	normal mortality/aging	J:361430
Gfm1^em2Rmrt/Gfm1^em2Rmrt C57BL/6NTac-Gfm1^em2Rmrt	abnormal fertility/fecundity	J:361430
	abnormal mitochondrial ATP synthesis coupled electron transport	J:361430
	normal behavior/neurological phenotype	J:361430
	decreased cytochrome-c oxidase activity	J:361430
	decreased liver enzyme/coenzyme activity	J:361430
	decreased protein level	J:361430
	normal growth/size/body region phenotype	J:361430
	normal homeostasis/metabolism phenotype	J:361430
	impaired mitochondrial translation	J:361430
	increased circulating alanine transaminase level	J:361430
	normal mortality/aging	J:361430
	normal muscle phenotype	J:361430
Gfm1^{tm1a(EUCOMM)Wtsi}/Gfm1⁺ C57BL/6N-Gfm1^{tm1a(EUCOMM)Wtsi}/Wtsi	increased circulating free fatty acids level	J:175295

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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