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Cux2 Gene Detail
Summary
  • Symbol
    Cux2
  • Name
    cut-like homeobox 2
  • Synonyms
    1700051K22Rik, Cutl2, Cux2, Cux-2, ENSMUSG00000072641
  • Feature Type
    protein coding gene
  • IDs
    MGI:107321
    NCBI Gene: 13048
Location & Maps
more
  • Sequence Map
    Chr5:121856366-122050102 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      193737 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 62.02 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CUX2, cut like homeobox 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CUX2, cut like homeobox 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDP2, CUTL2
  • Links
    NCBI Gene ID: 23316
    neXtProt AC: NX_O14529

  • Chr Location
    12q24.12; chr12:111034024-111350554 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    1
  • Gene trapped
    12
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Cux2
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit various neural defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024684 VEGA Gene Model | MGI Sequence Detail 193737 C57BL/6J ±  kb
transcript OTTMUST00000060705 VEGA | MGI Sequence Detail 8784 Not Applicable  
polypeptide OTTMUSP00000029644 VEGA | MGI Sequence Detail 1426 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    561 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    Genomic 1
    cDNA 15
    Primer pair 3
    Other 3

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-35787, MGI:1920667, MGI:3710627
References
more
  • Summaries
    All 128
    Developmental Gene Expression 85
    Gene Ontology 7
    Phenotypes 25
  • Earliest
    J:15712 Valarche I, et al., The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype. Development. 1993 Nov;119(3):881-96
  • Latest
    J:230869 Rodriguez-Tornos FM, et al., Cux1 Enables Interhemispheric Connections of Layer II/III Neurons by Regulating Kv1-Dependent Firing. Neuron. 2016 Feb 3;89(3):494-506

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory