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Cux2 Gene Detail
Summary
  • Symbol
    Cux2
  • Name
    cut-like homeobox 2
  • Synonyms
    1700051K22Rik, Cutl2, Cux2, Cux-2, ENSMUSG00000072641
  • Feature Type
    protein coding gene
  • IDs
    MGI:107321
    NCBI Gene: 13048
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:121996025-122188522 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 62.02 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    561 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107321
protein coding gene Chr5:121994429-122188522 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030040
protein coding gene Chr5:125433292-125647049 (-)
A/J MGP_AJ_G0030005
protein coding gene Chr5:120273947-120463872 (-)
AKR/J MGP_AKRJ_G0029941
protein coding gene Chr5:124140178-124332757 (-)
BALB/cJ MGP_BALBcJ_G0030016
protein coding gene Chr5:121611613-121807110 (-)
C3H/HeJ MGP_C3HHeJ_G0029733
protein coding gene Chr5:124720713-124934503 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030469
protein coding gene Chr5:130215887-130470171 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027695
protein coding gene Chr5:114890457-115079662 (-)
CAST/EiJ MGP_CASTEiJ_G0029142
protein coding gene Chr5:123820565-124038234 (-)
CBA/J MGP_CBAJ_G0029703
protein coding gene Chr5:135335345-135581353 (-)
DBA/2J MGP_DBA2J_G0029853
protein coding gene Chr5:120324036-120516615 (-)
FVB/NJ MGP_FVBNJ_G0029809
protein coding gene Chr5:119289570-119492987 (-)
LP/J MGP_LPJ_G0029942
protein coding gene Chr5:125977197-126188814 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029840
protein coding gene Chr5:139151663-139375150 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030510
protein coding gene Chr5:123690904-123902394 (-)
PWK/PhJ MGP_PWKPhJ_G0028856
protein coding gene Chr5:119071682-119271052 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028693
protein coding gene Chr5:121413665-121617737 (-)
WSB/EiJ MGP_WSBEiJ_G0029217
protein coding gene Chr5:124362885-124583865 (-)



Homology
more
  • Human Ortholog
    CUX2, cut like homeobox 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CUX2, cut like homeobox 2
  • Synonyms
    CDP2, CUTL2, DEE67, EIEE67
  • Links
    NCBI Gene ID: 23316
    neXtProt AC: NX_O14529
    UniProt: O14529

  • Chr Location
    12q24.11-q24.12; chr12:111034165-111350554 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human CUX2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit various neural defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13048 NCBI Gene Model | MGI Sequence Detail 192498 C57BL/6J ±  kb
    transcript NM_007804 RefSeq | MGI Sequence Detail 5133 ZRU/MplStud  
    polypeptide P70298 UniProt | EBI | MGI Sequence Detail 1426 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 16
      Primer pair 4
      Other 7

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-35787, MGI:1920667, MGI:3710627
    References
    more
    • Summaries
      All 199
      Developmental Gene Expression 112
      Gene Ontology 7
      Phenotypes 65
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:341393 Cheffer A, et al., DOT1L deletion impairs the development of cortical parvalbumin-expressing interneurons. Cereb Cortex. 2023 Sep 26;33(19):10272-10285

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory