Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of nervous system development; regulation of gene expression; and short-term memory. Acts upstream of or within cellular response to organic substance and negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including 1st branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 67. Orthologous to human CUX2 (cut like homeobox 2).