Fyco1
Gene Detail

Symbol

Name
ID

Fyco1
FYVE and coiled-coil domain containing 1
MGI:107277

Synonyms

2810409M01Rik, Mem2, ZFYVE7

Feature Type

protein coding gene

Genetic Map

Chromosome 9
74.52 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr9:123789886-123851886 bp, - strand From VEGA annotation of GRCm38   62001 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:11561  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fyco1

Human
homologs

Human Homolog		FYCO1, FYVE and coiled-coil domain containing 1
NCBI Gene ID		79443
neXtProt AC		NX_Q9BQS8
Human Synonyms		CATC2, CTRCT18, RUFY3, ZFYVE7
Human Chr (Location)		3p21.31; chr3:45917899-45995824 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human FYCO1

Mutations,
alleles, and
phenotypes

All mutations/alleles(2) : Gene trapped(2)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Fyco1 interacts with 358 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (11 annotations)

Process	plus-end-directed vesicle transport along microtubule, transport
Component	autophagic vacuole, cytoplasmic vesicle, ...
Function	metal ion binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (42)    Tissues (28)    Images (12)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	38
RT-PCR	4

cDNA source data(67)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(70) cDNA(69) Primer pair(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000044623 (Evidence)
Ensembl Gene Model	ENSMUSG00000025241 (Evidence)
Entrez Gene	17281 (Evidence)
UniGene	252941
DFCI	TC1655583, TC1624764, TC1585441
DoTS	DT.103559949, DT.99852426, DT.55259151, DT.488945
NIA Mouse Gene Index	U031481
Consensus CDS Project	CCDS40819.1
International Mouse Knockout Project Status	Fyco1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000044623	VEGA Gene Model | MGI Sequence Detail	62001	C57BL/6J
transcript	OTTMUST00000117392	VEGA | MGI Sequence Detail	7468	Not Applicable
polypeptide	OTTMUSP00000065657	VEGA | MGI Sequence Detail	1437	Not Applicable

All sequences(43) RefSeq(4) UniProt(1)

Polymorphisms

PCR(1) : SNPs within 2kb(1140 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR009038	GOLD
InterPro	IPR004012	RUN
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR017455	Zinc finger, FYVE-related
InterPro	IPR000306	Zinc finger, FYVE-type
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000029502	FYVE and coiled-coil domain-containing protein 1

References

(Earliest) J:40042 Heyer BS, et al., New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo. Mol Reprod Dev. 1997 Jun;47(2):148-56
(Latest) J:209359 Ma J, et al., Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production. J Immunol. 2014 Feb 15;192(4):1356-60
All references(40)

Other
accession IDs

MGD-MRK-35742, MGI:1917454