Fyco1 MGI Mouse Gene Detail - MGI:107277 - FYVE and coiled-coil domain containing 1

Fyco1 Gene Detail

Symbol

Fyco1
Name

FYVE and coiled-coil domain containing 1
Synonyms

2810409M01Rik, Mem2, ZFYVE7

Feature Type

protein coding gene
IDs

MGI:107277
NCBI Gene: 17281

Sequence Map

Chr9:123789886-123851886 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

62001 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 74.52 cM, cytoband F
Mapping Data

8 experiments

Human Ortholog

FYCO1, FYVE and coiled-coil domain containing 1

Vertebrate Orthologs

9

Human Ortholog

FYCO1, FYVE and coiled-coil domain containing 1
Orthology source: HomoloGene, HGNC
Synonyms

CATC2, CTRCT18, RUFY3, ZFYVE7
Links

HGNC:14673

NCBI Gene ID: 79443

neXtProt AC: NX_Q9BQS8
Chr Location

3p21.31; chr3:45917899-45995824 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 11561
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish
HCOP

human homology predictions: FYCO1
Gene Tree

Fyco1

Diseases

1 with human FYCO1 associations

				Human Disease	Mouse Models
				Cataract 18; CTRCT18 OMIM: 610019

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotype references

All Mutations and Alleles

2
Gene trapped

2
Incidental Mutations

Mutagenetix , APF , CvDC

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All GO Annotations

14
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

42
Tissues

28
cDNA Data

67
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

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Fyco1 interacts with 357 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

38
RefSeq

6
UniProt

2
CCDS

CCDS40819.1
UniGene

252941

			Length	Strain/Species	Flank
genomic	OTTMUSG00000044623	VEGA Gene Model \| MGI Sequence Detail	62001	C57BL/6J	± kb
transcript	OTTMUST00000117392	VEGA \| MGI Sequence Detail	7468	Not Applicable
polypeptide	OTTMUSP00000065657	VEGA \| MGI Sequence Detail	1437	Not Applicable

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SNPs within 2kb

1136 from dbSNP Build 142

PCR

1

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UniProt

2 Sequences
Protein Ontology

PR:000029502 FYVE and coiled-coil domain-containing protein 1
InterPro Domains

IPR000306 FYVE zinc finger

IPR009038 GOLD domain

IPR004012 RUN domain

IPR011011 Zinc finger, FYVE/PHD-type

IPR017455 Zinc finger, FYVE-related

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 70

cDNA 69

Primer pair 1

Microarray probesets 3

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MGD-MRK-35742, MGI:1917454

Summaries

All 36

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 3
Earliest

J:40042 Heyer BS, et al., New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo. Mol Reprod Dev. 1997 Jun;47(2):148-56
Latest

J:209359 Ma J, et al., Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production. J Immunol. 2014 Feb 15;192(4):1356-60

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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