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Coq7 Gene Detail
Summary
  • Symbol
    Coq7
  • Name
    demethyl-Q 7
  • Synonyms
    clk-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107207
    NCBI Gene: 12850
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:118108881-118132529 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 63.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    362 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107207
 protein coding gene Chr7:118108881-118132579 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032899
 protein coding gene Chr7:122346850-122372404 (-)
A/J MGP_AJ_G0032882
 protein coding gene Chr7:119251066-119274659 (-)
AKR/J MGP_AKRJ_G0032814
 protein coding gene Chr7:122292862-122316553 (-)
BALB/cJ MGP_BALBcJ_G0032887
 protein coding gene Chr7:118968367-118992120 (-)
C3H/HeJ MGP_C3HHeJ_G0032597
 protein coding gene Chr7:122191611-122215322 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033393
 protein coding gene Chr7:127249527-127273296 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030365
 protein coding gene Chr7:120687992-120712461 (-)
CAST/EiJ MGP_CASTEiJ_G0031925
 protein coding gene Chr7:113936389-113960200 (-)
CBA/J MGP_CBAJ_G0032570
 protein coding gene Chr7:131492813-131517783 (-)
DBA/2J MGP_DBA2J_G0032722
 protein coding gene Chr7:117282431-117306253 (-)
FVB/NJ MGP_FVBNJ_G0032675
 protein coding gene Chr7:117125179-117149653 (-)
LP/J MGP_LPJ_G0032816
 protein coding gene Chr7:123814067-123838847 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032707
 protein coding gene Chr7:132982618-133006327 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033413
 protein coding gene Chr7:121286004-121309695 (-)
PWK/PhJ MGP_PWKPhJ_G0031633
 protein coding gene Chr7:110184782-110209408 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031480
 protein coding gene Chr7:108014382-108038189 (-)
WSB/EiJ MGP_WSBEiJ_G0032038
 protein coding gene Chr7:122172019-122195678 (-)



Homology
more
  • Human Ortholog
    COQ7, coenzyme Q7, hydroxylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COQ7, coenzyme Q7, hydroxylase
  • Synonyms
    CAT5, CLK1, CLK-1, COQ10D8, HMNR9
  • Links
    NCBI Gene ID: 10229
    neXtProt AC: NX_Q99807
    UniProt: Q99807

  • Chr Location
    16p12.3; chr16:19067614-19083097 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human COQ7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 5 alleles in 7 genetic backgrounds
    1 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations in this gene are embryonic lethal during mid-gestation with aborted neurogenesis and abnormal mitochondria. Mice heterozygous for a null allele exhibit extended lifespan with mitochondrial dysfunction and altered inner and outer membrane ubiquinone levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    107
  • cDNA Data
    37
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12850 NCBI Gene Model | MGI Sequence Detail 23649 C57BL/6J ±  kb
    transcript NM_001304758 RefSeq | MGI Sequence Detail 1221 ZRU/MplStud  
    polypeptide P97478 UniProt | EBI | MGI Sequence Detail 217 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 39
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35669
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 7
      Gene Ontology 14
      Phenotypes 22
    • Earliest
      J:33381 Jonassen T, et al., Isolation and sequencing of the rat Coq7 gene and the mapping of mouse Coq7 to chromosome 7. (Correction appears in Arch Biochem Biophys 1996; 335(1):227). Arch Biochem Biophys. 1996 Jun 15;330(2):285-9
    • Latest
      J:305946 Xu M, et al., The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Development. 2021 Apr 15;148(8):dev199026
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory