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Zic4 Gene Detail
Summary
  • Symbol
    Zic4
  • Name
    zinc finger protein of the cerebellum 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:107201
    NCBI Gene: 22774
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:91365825-91389351 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 48.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107201
protein coding gene Chr9:91362413-91389351 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035124
protein coding gene Chr9:92377684-92405178 (+)
A/J MGP_AJ_G0035105
protein coding gene Chr9:89167288-89193834 (+)
AKR/J MGP_AKRJ_G0035037
protein coding gene Chr9:91235623-91263444 (+)
BALB/cJ MGP_BALBcJ_G0035098
protein coding gene Chr9:88793021-88819361 (+)
C3H/HeJ MGP_C3HHeJ_G0034808
protein coding gene Chr9:91712642-91740107 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035618
protein coding gene Chr9:94943120-94976981 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032521
protein coding gene Chr9:87238782-87265488 (+)
CAST/EiJ MGP_CASTEiJ_G0034120
protein coding gene Chr9:91466740-91495612 (+)
CBA/J MGP_CBAJ_G0034776
protein coding gene Chr9:98208794-98247657 (+)
DBA/2J MGP_DBA2J_G0034938
protein coding gene Chr9:88690855-88717464 (+)
FVB/NJ MGP_FVBNJ_G0034886
protein coding gene Chr9:87672210-87698663 (+)
LP/J MGP_LPJ_G0035017
protein coding gene Chr9:92592770-92619700 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034925
protein coding gene Chr9:100007322-100033621 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035638
protein coding gene Chr9:91493227-91521406 (+)
PWK/PhJ MGP_PWKPhJ_G0033827
protein coding gene Chr9:88853299-88884081 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033660
protein coding gene Chr9:91504481-91540316 (+)
WSB/EiJ MGP_WSBEiJ_G0034240
protein coding gene Chr9:91387186-91415448 (+)



Homology
more
  • Human Ortholog
    ZIC4, Zic family member 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZIC4, Zic family member 4
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 84107
    neXtProt AC: NX_Q8N9L1
    UniProt: Q8N9L1

  • Chr Location
    3q24; chr3:147386048-147406893 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32075
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZIC4
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Zic4 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit posterior cerebellar hypoplasia and a mild defect in anterior cerebellar foliation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22774 NCBI Gene Model | MGI Sequence Detail 23527 C57BL/6J ±  kb
    transcript NM_009576 RefSeq | MGI Sequence Detail 4088 C57BL/6  
    polypeptide Q61467 UniProt | EBI | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 4
      cDNA 14
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-35662
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:33727 Aruga J, et al., Identification and characterization of Zic4, a new member of the mouse Zic gene family. Gene. 1996 Jun 26;172(2):291-4
    • Latest
      J:254523 Magno L, et al., NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory. Cell Rep. 2017 Aug 15;20(7):1572-1584

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory