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Zic4 Gene Detail
Summary
  • Symbol
    Zic4
  • Name
    zinc finger protein of the cerebellum 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:107201
    NCBI Gene: 22774
Location & Maps
more
  • Sequence Map
    Chr9:91362413-91389348 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26936 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 48.26 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ZIC4, Zic family member 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZIC4, Zic family member 4
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 84107
    neXtProt AC: NX_Q8N9L1

  • Chr Location
    3q24; chr3:147386048-147407476 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32075
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZIC4
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Zic4 mouse models

Human Disease Mouse Models
       Dandy-Walker Syndrome; DWS   OMIM: 220200 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Zic4
  • Incidental Mutations
Mice heterozygous for a knock-out allele exhibit posterior cerebellar hypoplasia and a mild defect in anterior cerebellar foliation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038052 VEGA Gene Model | MGI Sequence Detail 26936 C57BL/6J ±  kb
transcript OTTMUST00000098031 VEGA | MGI Sequence Detail 3891 Not Applicable  
polypeptide OTTMUSP00000055017 VEGA | MGI Sequence Detail 341 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    72 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 3
    cDNA 13
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-35662
References
more
  • Summaries
    All 38
    Developmental Gene Expression 14
    Diseases 2
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:33727 Aruga J, et al., Identification and characterization of Zic4, a new member of the mouse Zic gene family. Gene. 1996 Jun 26;172(2):291-4
  • Latest
    J:223924 Zhao W, et al., Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain. Hum Mol Genet. 2015 Aug 15;24(16):4686-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory