Zic4
Gene Detail

Symbol Name ID

Zic4 zinc finger protein of the cerebellum 4 MGI:107201

Feature Type

protein coding gene

Genetic Map

Chromosome 9

48.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:91362413-91389348 bp, + strand From VEGA annotation of GRCm38   26936 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32075  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Zic4

Human homologs

Human Homolog		ZIC4, Zic family member 4
NCBI Gene ID		84107
neXtProt AC		NX_Q8N9L1
Human Chr (Location)		3q24; chr3:147103835-147124596 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice heterozygous for a knock-out allele exhibit posterior cerebellar hypoplasia and a mild defect in anterior cerebellar foliation.

 
Human Diseases Modeled Using Mouse Zic4 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Component	nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (127)    Tissues (85)    Images (14)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	101
RNase protection	26

cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(3) cDNA(11) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000038052 (Evidence)
Ensembl Gene Model	ENSMUSG00000036972 (Evidence)
Entrez Gene	22774 (Evidence)
DFCI	TC1584116, TC1588532, TC1593004, TC1629704, TC1632287
DoTS	DT.101713907, DT.40148714, DT.40158241, DT.55280400, DT.91333008, DT.91336016, DT.91557409
NIA Mouse Gene Index	U010850, U044683
Consensus CDS Project	CCDS23404.1
International Mouse Knockout Project Status	Zic4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000038052	VEGA Gene Model | MGI Sequence Detail	26936	C57BL/6J
transcript	OTTMUST00000098030	VEGA | MGI Sequence Detail	1591	Not Applicable
polypeptide	OTTMUSP00000055016	VEGA | MGI Sequence Detail	353	Not Applicable

All sequences(80) RefSeq(2) UniProt(8)

Polymorphisms

PCR(1) : SNPs(43 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000017668	zinc finger protein ZIC 4

References

(Earliest) J:33727 Aruga J, et al., Identification and characterization of Zic4, a new member of the mouse Zic gene family. Gene. 1996 Jun 26;172(2):291-4
(Latest) J:190459 Nieman BJ, et al., If the skull fits: magnetic resonance imaging and microcomputed tomography for combined analysis of brain and skull phenotypes in the mouse. Physiol Genomics. 2012 Oct 17;44(20):992-1002
All references(39)

Other accession IDs

MGD-MRK-35662