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Zic4
Gene Detail
Symbol

Name
ID
Zic4
zinc finger protein of the cerebellum 4
MGI:107201
Feature Type
protein coding gene
Genetic Map
Chromosome 9
48.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:91362413-91389348 bp, + strand
From VEGA annotation of GRCm38

  26936 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32075  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Zic4

Human
homologs
Human Homolog ZIC4, Zic family member 4
NCBI Gene ID 84107
neXtProt AC  NX_Q8N9L1
Human Chr (Location)  3q24; chr3:147386048-147406809 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice heterozygous for a knock-out allele exhibit posterior cerebellar hypoplasia and a mild defect in anterior cerebellar foliation.
 
Human Diseases Modeled Using Mouse Zic4 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Zic4 interacts with 356 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (195)    Tissues (124)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 169
RNase protection 26
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(3) cDNA(13) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000038052 (Evidence)
Ensembl Gene ModelENSMUSG00000036972 (Evidence)
Entrez Gene22774 (Evidence)
DFCITC1584116, TC1588532, TC1593004, TC1613825, TC1629704, TC1632287
DoTSDT.101713907, DT.40148714, DT.40158241, DT.55280400, DT.91333008, DT.91336016, DT.91557409
NIA Mouse Gene IndexU010850, U044683
Consensus CDS ProjectCCDS23404.1
International Mouse Knockout Project StatusZic4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038052 VEGA Gene Model | MGI Sequence Detail 26936 C57BL/6J ±  kb
transcript OTTMUST00000098031 VEGA | MGI Sequence Detail 3891 Not Applicable 
polypeptide OTTMUSP00000055017 VEGA | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(122) RefSeq(44) UniProt(8)
Polymorphisms
PCR(1) : SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017668 zinc finger protein ZIC 4
References
(Earliest) J:33727 Aruga J, et al., Identification and characterization of Zic4, a new member of the mouse Zic gene family. Gene. 1996 Jun 26;172(2):291-4
(Latest) J:198578 Chervenak AP, et al., Spatiotemporal expression of zic genes during vertebrate inner ear development. Dev Dyn. 2013 Jul;242(7):897-908
All references(40)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35662

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory