Zic1/Zic4^tm1Kjmi
Targeted Allele Detail

Summary

• Symbol: Zic1/Zic4^tm1Kjmi
• Name: zinc finger protein of the cerebellum 4; targeted mutation 1, Kathleen J Millen
• MGI ID: MGI:3510681
• Synonyms: Zic1^-Zic4^-
• Gene: Zic4 Location: Chr9:91247636-91271404 bp, + strand Genetic Position: Chr9, 48.26 cM
• Alliance: Zic1/Zic4^tm1Kjmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93955
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: A targeting vector was designed to replace the 17.6 kb region between Zic1 and Zic4, as well as the coding region of the first exon of Zic4 and the entire first exon of Zic1. Transient Cre expression removed the neo in ES cells. (J:93955)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zic4 Mutation: 24 strains or lines available

References

• Original: J:93955 Grinberg I, et al., Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation. Nat Genet. 2004 Oct;36(10):1053-5
• All: 4 reference(s)