About   Help   FAQ
Hsd17b3
Gene Detail
 Symbol
Name
ID
Hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
MGI:107177
Synonyms 17(beta)HSD type 3
Feature Type protein coding gene
Genetic Map
Chromosome 13
33.26 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:64058274-64089201 bp, - strand
From NCBI annotation of GRCm38

  30928 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20089  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 11-beta-HSD1
Gene Tree: Hsd17b3

Human
homologs
Human Homolog HSD17B3, hydroxysteroid (17-beta) dehydrogenase 3
NCBI Gene ID 3293
neXtProt AC  NX_P37058
Human Synonyms  EDH17B3, SDR12C2
Human Chr (Location)  9q22; chr9:96235306-96302302 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HSD17B3
Alleles
and
phenotypes
All alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process lipid metabolic process, metabolic process, ...
Component intracellular membrane-bounded organelle
Function estradiol 17-beta-dehydrogenase activity, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (10)    Tissues (3)   
Theiler Stages: 23, 25, 28
Assay TypeResults
RT-PCR 10
cDNA source data(1)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(3) cDNA(1) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000033122 (Evidence)
Entrez Gene15487 (Evidence)
UniGene5109
DFCITC1592466
DoTSDT.101320265, DT.91332805, DT.94227702
NIA Mouse Gene IndexU034905
EC1.1.1.64
Consensus CDS ProjectCCDS26594.1
International Mouse Knockout Project StatusHsd17b3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15487 NCBI Gene Model | MGI Sequence Detail 30928 C57BL/6J ±  kb
transcript NM_008291 RefSeq | MGI Sequence Detail 1286 C57BL/6 
polypeptide P70385 UniProt | EBI | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(470 from dbSNP Build 137)    SNPs within 2kb including multiple locations(474)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000008780 testosterone 17-beta-dehydrogenase 3
Graphical View of Protein Domain Structure
References (Earliest) J:33772 Sha J, et al., Both reductive forms of 17 beta-hydroxysteroid dehydrogenase (types 1 and 3) are expressed during development in the mouse testis. Biochem Biophys Res Commun. 1996 May 6;222(1):90-4
(Latest) J:192626 Miyado M, et al., Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal Leydig cells but permits normal genital and reproductive development. Endocrinology. 2012 Dec;153(12):6033-40
All references(35)
Other
accession IDs
MGD-MRK-35638

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory