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Hsd17b3
Gene Detail
Symbol

Name
ID
Hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
MGI:107177
Synonyms
17(beta)HSD type 3
Feature Type
protein coding gene
Genetic Map
Chromosome 13
33.26 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:64058274-64089201 bp, - strand
From NCBI annotation of GRCm38

  30928 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20089  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 11-beta-HSD1
Gene Tree: Hsd17b3

Human
homologs
Human Homolog HSD17B3, hydroxysteroid (17-beta) dehydrogenase 3
NCBI Gene ID 3293
neXtProt AC  NX_P37058
Human Synonyms  EDH17B3, SDR12C2
Human Chr (Location)  9q22; chr9:96235306-96302302 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HSD17B3
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Hsd17b3 interacts with 43 markers (Mir32, Mir92-1, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process lipid metabolic process, metabolic process, ...
Component intracellular membrane-bounded organelle
Function estradiol 17-beta-dehydrogenase activity, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (10)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 10
cDNA source data(1)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(3) cDNA(1) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000033122 (Evidence)
Entrez Gene15487 (Evidence)
UniGene5109
DFCITC1592466
DoTSDT.101320265, DT.91332805, DT.94227702
NIA Mouse Gene IndexU034905
EC1.1.1.64
Consensus CDS ProjectCCDS26594.1
International Mouse Knockout Project StatusHsd17b3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15487 NCBI Gene Model | MGI Sequence Detail 30928 C57BL/6J ±  kb
transcript NM_008291 RefSeq | MGI Sequence Detail 1286 C57BL/6 
polypeptide P70385 UniProt | EBI | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(470 from dbSNP Build 137)    SNPs within 2kb including multiple locations(474)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000008780 testosterone 17-beta-dehydrogenase 3
Graphical View of Protein Domain Structure
References
(Earliest) J:33772 Sha J, et al., Both reductive forms of 17 beta-hydroxysteroid dehydrogenase (types 1 and 3) are expressed during development in the mouse testis. Biochem Biophys Res Commun. 1996 May 6;222(1):90-4
(Latest) J:212156 Howerton CL, et al., Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9639-44
All references(36)
Other
accession IDs
MGD-MRK-35638

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory