Hsd17b3
Gene Detail

Symbol Name ID

Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 MGI:107177

Synonyms

17(beta)HSD type 3

Feature Type

protein coding gene

Genetic Map

Chromosome 13

33.26 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr13:64058274-64089201 bp, - strand From NCBI annotation of GRCm38   30928 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20089  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 11-beta-HSD1
Gene Tree: Hsd17b3

Human homologs

Human Homolog		HSD17B3, hydroxysteroid (17-beta) dehydrogenase 3
NCBI Gene ID		3293
neXtProt AC		NX_P37058
Human Synonyms		EDH17B3, SDR12C2
Human Chr (Location)		9q22; chr9:98997589-99064434 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HSD17B3

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	lipid metabolic process, metabolic process, ...
Component	intracellular membrane-bounded organelle
Function	estradiol 17-beta-dehydrogenase activity, oxidoreductase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (10)    Tissues (3)   
Theiler Stages: 23, 25, 28

Assay Type	Results
RT-PCR	10

cDNA source data(1)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(3) cDNA(1) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000033122 (Evidence)
Entrez Gene	15487 (Evidence)
UniGene	5109
DFCI	TC1592466
DoTS	DT.101320265, DT.91332805, DT.94227702
NIA Mouse Gene Index	U034905
EC	1.1.1.64
Consensus CDS Project	CCDS26594.1
International Mouse Knockout Project Status	Hsd17b3

Sequences

Length	Strain/Species
genomic	15487	NCBI Gene Model | MGI Sequence Detail	30928	C57BL/6J
transcript	NM_008291	RefSeq | MGI Sequence Detail	1286	C57BL/6
polypeptide	P70385	UniProt | EBI | MGI Sequence Detail	305	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(201 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002347	Glucose/ribitol dehydrogenase
InterPro	IPR016040	NAD(P)-binding domain
InterPro	IPR020904	Short-chain dehydrogenase/reductase, conserved site
InterPro	IPR002198	Short-chain dehydrogenase/reductase SDR
Protein Ontology	PR:000008780	testosterone 17-beta-dehydrogenase 3

Graphical View of Protein Domain Structure

References

(Earliest) J:33772 Sha J, et al., Both reductive forms of 17 beta-hydroxysteroid dehydrogenase (types 1 and 3) are expressed during development in the mouse testis. Biochem Biophys Res Commun. 1996 May 6;222(1):90-4
(Latest) J:192626 Miyado M, et al., Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal Leydig cells but permits normal genital and reproductive development. Endocrinology. 2012 Dec;153(12):6033-40
All references(35)

Other accession IDs

MGD-MRK-35638