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Hsd17b3 Gene Detail
Summary
  • Symbol
    Hsd17b3
  • Name
    hydroxysteroid (17-beta) dehydrogenase 3
  • Synonyms
    17(beta)HSD type 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107177
    NCBI Gene: 15487
  • Gene Overview
    MyGene.info: HSD17B3
Location & Maps
more
  • Sequence Map
    Chr13:64058274-64089201 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30928 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HSD17B3, hydroxysteroid (17-beta) dehydrogenase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSD17B3, hydroxysteroid (17-beta) dehydrogenase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EDH17B3, SDR12C2
  • Links
    NCBI Gene ID: 3293
    neXtProt AC: NX_P37058

  • Chr Location
    9q22; chr9:96235306-96313983 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human HSD17B3 associations

Human Disease Mouse Models
       17-beta Hydroxysteroid Dehydrogenase III Deficiency   OMIM: 264300
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Hsd17b3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033122 Ensembl Gene Model | MGI Sequence Detail 30928 C57BL/6J ±  kb
transcript ENSMUST00000166224 Ensembl | MGI Sequence Detail 1286 Not Applicable  
polypeptide ENSMUSP00000132011 Ensembl | MGI Sequence Detail 305 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    466 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008780 testosterone 17-beta-dehydrogenase 3
  • EC
  • InterPro Domains
    IPR016040 NAD(P)-binding domain
    IPR020904 Short-chain dehydrogenase/reductase, conserved site
    IPR002347 Short-chain dehydrogenase/reductase SDR
Molecular
Reagents
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  • All nucleic 3
    cDNA 1
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-35638
References
more
  • Summaries
    All 36
    Developmental Gene Expression 10
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:33772 Sha J, et al., Both reductive forms of 17 beta-hydroxysteroid dehydrogenase (types 1 and 3) are expressed during development in the mouse testis. Biochem Biophys Res Commun. 1996 May 6;222(1):90-4
  • Latest
    J:223361 Kaftanovskaya EM, et al., Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis. FASEB J. 2015 Jun;29(6):2327-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory