Ppp3ca
Gene Detail

Symbol Name ID

Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform MGI:107164

Synonyms

2900074D19Rik, Caln, Calna, CN, CnA, PP2BA alpha, PP2B alpha 1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

63.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:136670124-136937727 bp, + strand From VEGA annotation of GRCm38   267604 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ppp3ca ± 2 cM)

Protein SuperFamily: serine/threonine protein phosphatase 2B catalytic subunit
Gene Tree: Ppp3ca

Human ortholog

PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme NCBI Gene ID 5530
Human Synonyms: CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B
Human Chr4:101944587-102268628 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(18) : Targeted(6) Gene trapped(12)
 

Mice homozygous for a null allele exhibit decreased T cell proliferation and abnormal mossy fibers.

 
Human Diseases Modeled Using Mouse Ppp3ca (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (49 annotations)

Process	calcineurin-NFAT signaling cascade, calcium ion transport, ...
Component	calcineurin complex, cytosol, ...
Function	calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (86)    Tissues (55)    Images (20)
Theiler Stages: 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	77
RT-PCR	9

cDNA source data(172)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(175) cDNA(172) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016446 (Evidence)
Ensembl Gene Model	ENSMUSG00000028161 (Evidence)
Entrez Gene	19055 (Evidence)
UniGene	331389
DFCI	TC1574453, TC1587797, TC1653682
DoTS	DT.101409017, DT.101725256, DT.101725390, DT.535071, DT.87072611, DT.94347221
NIA Mouse Gene Index	U003894
EC	3.1.3.16
Consensus CDS Project	CCDS17860.1
International Mouse Knockout Project Status	Ppp3ca

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016446	VEGA Gene Model | MGI Sequence Detail	267604	C57BL/6J
transcript	OTTMUST00000039612	VEGA | MGI Sequence Detail	2194	Not Applicable
polypeptide	OTTMUSP00000017685	VEGA | MGI Sequence Detail	521	Not Applicable

All sequences(66) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(1065 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004843	Metallophosphoesterase domain
InterPro	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Protein Ontology	PR:000003278	serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

References

(Earliest) J:9480 Kincaid RL, et al., Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin. Proc Natl Acad Sci U S A. 1988 Dec;85(23):8983-7
(Latest) J:190647 Oshima S, et al., Elevated expression of calcineurin subunits during active mineralization of developing mouse molar teeth. Eur J Oral Sci. 2012 Oct;120(5):386-94
All references(117)

Other accession IDs

MGD-MRK-1735, MGD-MRK-1736, MGD-MRK-35625, MGI:1920287, MGI:2139807, MGI:2139982