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Ppp3ca Gene Detail
Summary
  • Symbol
    Ppp3ca
  • Name
    protein phosphatase 3, catalytic subunit, alpha isoform
  • Synonyms
    2900074D19Rik, Caln, Calna, CN, CnA, PP2BA alpha, PP2B alpha 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107164
    NCBI Gene: 19055
  • Gene Overview
    MyGene.info: PPP3CA
Location & Maps
more
  • Sequence Map
    Chr3:136670124-136937727 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      267604 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PPP3CA, protein phosphatase 3 catalytic subunit alpha
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PPP3CA, protein phosphatase 3 catalytic subunit alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B
  • Links
    NCBI Gene ID: 5530
    neXtProt AC: NX_Q08209

  • Chr Location
    4q24; chr4:101023430-101347471 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 4 genetic backgrounds
    12 phenotypes from multigenic genotypes
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Chemically induced (other)
    1
  • Gene trapped
    12
  • Radiation induced
    1
  • Targeted
    6
  • Transgenic
    6
  • Genomic Mutations
    2 involving Ppp3ca
  • Incidental Mutations
Mice homozygous for a null allele exhibit decreased T cell proliferation and abnormal mossy fibers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016446 VEGA Gene Model | MGI Sequence Detail 267604 C57BL/6J ±  kb
transcript OTTMUST00000039612 VEGA | MGI Sequence Detail 2194 Not Applicable  
polypeptide OTTMUSP00000017685 VEGA | MGI Sequence Detail 521 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1227 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000003278 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
  • PDB
  • EC
  • InterPro Domains
    IPR004843 Calcineurin-like phosphoesterase domain, apaH type
    IPR029052 Metallo-dependent phosphatase-like
    IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Molecular
Reagents
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  • All nucleic 24
    cDNA 21
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-1735, MGD-MRK-1736, MGD-MRK-35625, MGI:1920287, MGI:2139807, MGI:2139982
References
more
  • Summaries
    All 128
    Developmental Gene Expression 17
    Gene Ontology 28
    Phenotypes 75
  • Earliest
    J:9480 Kincaid RL, et al., Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin. Proc Natl Acad Sci U S A. 1988 Dec;85(23):8983-7
  • Latest
    J:224980 Lee KY, et al., Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism. Nat Commun. 2015;6:8054

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory