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Ppp3ca
Gene Detail
 Symbol
Name
ID
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
MGI:107164
Synonyms 2900074D19Rik, Caln, Calna, CN, CnA, PP2BA alpha, PP2B alpha 1
Feature Type protein coding gene
Genetic Map
Chromosome 3
63.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:136670124-136937727 bp, + strand
From VEGA annotation of GRCm38

  267604 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55497  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: serine/threonine protein phosphatase 2B catalytic subunit
Gene Tree: Ppp3ca

Human
homologs
Human Homolog PPP3CA, protein phosphatase 3, catalytic subunit, alpha isozyme
NCBI Gene ID 5530
neXtProt AC  NX_Q08209
Human Synonyms  CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B
Human Chr (Location)  4q24; chr4:101023430-101347471 (-)  GRCh38
Alleles
and
phenotypes
All alleles(18) : Gene trapped(12) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased T cell proliferation and abnormal mossy fibers.
 
Human Diseases Modeled Using Mouse Ppp3ca (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process calcineurin-NFAT signaling cascade, calcium ion transport, ...
Component calcineurin complex, cytoplasm, ...
Function calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (86)    Tissues (55)    Images (20)
Theiler Stages: 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 77
RT-PCR 9
cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(24) cDNA(21) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016446 (Evidence)
Ensembl Gene ModelENSMUSG00000028161 (Evidence)
Entrez Gene19055 (Evidence)
DFCITC1574453, TC1587797, TC1653682
DoTSDT.101409017, DT.101725256, DT.101725390, DT.535071, DT.87072611, DT.94347221
NIA Mouse Gene IndexU003894
EC3.1.3.16
Consensus CDS ProjectCCDS17860.1
International Mouse Knockout Project StatusPpp3ca
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016446 VEGA Gene Model | MGI Sequence Detail 267604 C57BL/6J ±  kb
transcript OTTMUST00000039612 VEGA | MGI Sequence Detail 2194 Not Applicable 
polypeptide OTTMUSP00000017685 VEGA | MGI Sequence Detail 521 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(1234 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004843 Metallophosphoesterase domain
InterPro IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Protein Ontology PR:000003278 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
References (Earliest) J:9480 Kincaid RL, et al., Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin. Proc Natl Acad Sci U S A. 1988 Dec;85(23):8983-7
(Latest) J:207976 Li Q, et al., The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife. 2014;3:e01201
All references(122)
Other
accession IDs
MGD-MRK-1735, MGD-MRK-1736, MGD-MRK-35625, MGI:1920287, MGI:2139807, MGI:2139982

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory