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Ppp3ca Gene Detail
Summary
  • Symbol
    Ppp3ca
  • Name
    protein phosphatase 3, catalytic subunit, alpha isoform
  • Synonyms
    2900074D19Rik, Caln, Calna, CN, CnA, PP2BA alpha, PP2B alpha 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107164
    NCBI Gene: 19055
  • Gene Overview
    MyGene.info: PPP3CA
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:136670124-136937727 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      267604 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 63.34 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PPP3CA, protein phosphatase 3 catalytic subunit alpha
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PPP3CA, protein phosphatase 3 catalytic subunit alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CALN, CALNA, CALNA1, CCN1, CNA1, IECEE, IECEE1, PPP2B
  • Links
    NCBI Gene ID: 5530
    neXtProt AC: NX_Q08209
    UniProt: Q08209

  • Chr Location
    4q24; chr4:101023430-101347471 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ppp3ca mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 5 genetic backgrounds
    14 phenotypes from multigenic genotypes
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased T cell proliferation and abnormal mossy fibers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016446 VEGA Gene Model | MGI Sequence Detail 267604 C57BL/6J ±  kb
    transcript OTTMUST00000039612 VEGA | MGI Sequence Detail 2194 Not Applicable  
    polypeptide OTTMUSP00000017685 VEGA | MGI Sequence Detail 521 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1227 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000003278 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
    • PDB
    • EC
    • InterPro Domains
      IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
      IPR029052 Metallo-dependent phosphatase-like
      IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 22
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1735, MGD-MRK-1736, MGD-MRK-35625, MGI:1920287, MGI:2139807, MGI:2139982
    References
    more
    • Summaries
      All 203
      Developmental Gene Expression 19
      Diseases 2
      Gene Ontology 36
      Phenotypes 82
    • Earliest
      J:9480 Kincaid RL, et al., Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin. Proc Natl Acad Sci U S A. 1988 Dec;85(23):8983-7
    • Latest
      J:256956 Brinegar AE, et al., Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions. Elife. 2017 Aug 11;6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/18/2018
    MGI 6.12
    The Jackson Laboratory