Ppp3ca Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
MGI:107164

14 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Hdac5^tm1Eno/Hdac5^tm1Eno Tg(Myh6-Ppp3ca)37Eno/0 involves: 129S2/SvPas * C57BL/6	cardiac hypertrophy	J:93021
	postnatal lethality, complete penetrance	J:93021
	premature death	J:93021
Hdac9^tm1Eno/Hdac9^tm1Eno Tg(Myh6-Ppp3ca)37Eno/? involves: 129S1/Sv * 129X1/SvJ * FVB	abnormal myocardium layer morphology	J:78734
	cardiac hypertrophy	J:78734
Mir22^tm1.2Dzw/Mir22^tm1.2Dzw Tg(Myh6-Ppp3ca)37Eno/0 involves: C57BL/6 * FVB	abnormal heart ventricle wall thickness	J:213308
	cardiac fibrosis	J:213308
	cardiac hypertrophy	J:213308
Mir208a^tm1.1Eno/Mir208a^tm1.1Eno Tg(Myh6-Ppp3ca)37Eno/0 involves: C57BL/6 * FVB	normal cardiovascular system phenotype	J:120908
Mlip^{tm1.1(cre)Dzw}/Mlip^{tm1.1(cre)Dzw} Tg(Myh6-Ppp3ca)37Eno/0 involves: C57BL/6 * FVB	decreased cardiac muscle contractility	J:227485
	decreased heart left ventricle wall thickness	J:227485
	dilated heart left ventricle	J:227485
	premature death	J:227485
Myoz2^tm1Eno/Myoz2^tm1Eno Tg(Myh6-Ppp3ca)37Eno/0 involves: 129 * C57BL/6J	cardiac hypertrophy	J:94665
	increased myocardial fiber size	J:94665
	premature death	J:94665
Nfatc3^tm1Glm/Nfatc3^tm1Glm Tg(Myh6-Ppp3ca)37Eno/? involves: 129S2/SvPas * FVB	cardiac hypertrophy	J:79608
Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Tg(Myh6-Ppp3ca)37Eno/? involves: 129S7/SvEvBrd * C57BL/6 * FVB	abnormal myocardium layer morphology	J:79608
	cardiac hypertrophy	J:79608
	dilated heart	J:79608
Rcan1^tm1Jmol/Rcan1^tm1Jmol Tg(Myh6-Ppp3ca)37Eno/0 involves: 129 * C57BL/6 * FVB	increased heart weight	J:109586
Rcan2^tm1Jmol/Rcan2^tm1Jmol Tg(Myh6-Ppp3ca)37Eno/0 involves: 129 * C57BL/6 * FVB	increased heart weight	J:109586
Tg(Myh6-MEF2A)1Jmol/0 Tg(Myh6-Ppp3ca)37Eno/0 involves: FVB	cardiac hypertrophy	J:111573
Tg(Myh6-Mef2c)2Jmol/0 Tg(Myh6-Ppp3ca)37Eno/0 involves: FVB	abnormal heart atrium morphology	J:111573
	cardiac hypertrophy	J:111573
	decreased cardiac muscle contractility	J:111573

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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