Myoz2^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Myoz2^tm1Eno
• Name: myozenin 2; targeted mutation 1, Eric N Olson
• MGI ID: MGI:3525108
• Synonyms: Myoz2^-
• Gene: Myoz2 Location: Chr3:122799855-122828649 bp, - strand Genetic Position: Chr3, 53.78 cM, cytoband G3
• Alliance: Myoz2^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94665
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An nLacZ-PGK-neo cassette replaced exon 2, which contains the translation start site. Beta-galactosidase staining of mutant heart demonstrated lacZ was expressed. RT-PCR showed a lack of wild-type transcripts and immunostaining lacked detectable protein in mutant heart sections. (J:94665)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myoz2 Mutation: 13 strains or lines available

References

• Original: J:94665 Frey N, et al., Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress. Nat Med. 2004 Dec;10(12):1336-1343
• All: 7 reference(s)