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Ppp3cb Gene Detail
Summary
  • Symbol
    Ppp3cb
  • Name
    protein phosphatase 3, catalytic subunit, beta isoform
  • Synonyms
    1110063J16Rik, Calnb, Cnab, CnAbeta, PP2BA beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:107163
    NCBI Gene: 19056
  • Gene Overview
    MyGene.info: PPP3CB
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20499364-20546573 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.53 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107163
protein coding gene Chr14:20499364-20546573 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021038
protein coding gene Chr14:13260774-13312853 (-)
A/J MGP_AJ_G0020987
protein coding gene Chr14:12952802-12999852 (-)
AKR/J MGP_AKRJ_G0020964
protein coding gene Chr14:13478107-13525188 (-)
BALB/cJ MGP_BALBcJ_G0020990
protein coding gene Chr14:13056725-13103937 (-)
C3H/HeJ MGP_C3HHeJ_G0020774
protein coding gene Chr14:13415386-13462936 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021423
protein coding gene Chr14:13756881-13808755 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018991
protein coding gene Chr14:13263487-13313904 (-)
CAST/EiJ MGP_CASTEiJ_G0020298
protein coding gene Chr14:13176042-13224567 (-)
CBA/J MGP_CBAJ_G0020740
protein coding gene Chr14:14456616-14508608 (-)
DBA/2J MGP_DBA2J_G0020863
protein coding gene Chr14:12778570-12825632 (-)
FVB/NJ MGP_FVBNJ_G0020846
protein coding gene Chr14:12672710-12719654 (-)
LP/J MGP_LPJ_G0020939
protein coding gene Chr14:13483229-13534309 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020872
protein coding gene Chr14:14227527-14284785 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021456
protein coding gene Chr14:13265871-13313714 (-)
PWK/PhJ MGP_PWKPhJ_G0020047
protein coding gene Chr14:12344479-12392501 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019869
protein coding gene Chr14:13048204-13094712 (-)
WSB/EiJ MGP_WSBEiJ_G0020354
protein coding gene Chr14:13250074-13299453 (-)



Homology
more
  • Human Ortholog
    PPP3CB, protein phosphatase 3 catalytic subunit beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPP3CB, protein phosphatase 3 catalytic subunit beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CALNA2, CALNB, CNA2, PP2Bbeta
  • Links
    NCBI Gene ID: 5532
    neXtProt AC: NX_P16298
    UniProt: P16298

  • Chr Location
    10q22.2; chr10:73436428-73496024 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 5 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    1 images
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice have small hearts and thymi, and reduced body weight. Cardiac function is normal, but mice lack a cardiac hypertrophic response to pressure overload, angiotensin II, or isopreteronol. Thymi are hypoplastic, with abnormal T cell development and reduced numbers of T cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19056 NCBI Gene Model | MGI Sequence Detail 47210 C57BL/6J ±  kb
    transcript NM_008914 RefSeq | MGI Sequence Detail 3848 C57BL/6  
    polypeptide P48453 UniProt | EBI | MGI Sequence Detail 525 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013148 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
    • EC
    • InterPro Domains
      IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
      IPR029052 Metallo-dependent phosphatase-like
      IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 17
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-1737, MGD-MRK-35624, MGI:1913465
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 7
      Gene Ontology 17
      Phenotypes 43
    • Earliest
      J:33287 Guerini D, et al., Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain. Proc Natl Acad Sci U S A. 1989 Dec;86(23):9183-7
    • Latest
      J:256956 Brinegar AE, et al., Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions. Elife. 2017 Aug 11;6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory