Ppp3cc
Gene Detail

Symbol Name ID

Ppp3cc protein phosphatase 3, catalytic subunit, gamma isoform MGI:107162

Synonyms

Calnc, PP2BA gamma

Feature Type

protein coding gene

Genetic Map

Chromosome 14

36.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:70217898-70289449 bp, - strand From NCBI annotation of GRCm38   71552 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68475  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: serine/threonine protein phosphatase 2B catalytic subunit
Gene Tree: Ppp3cc

Human homologs

Human Homolog		PPP3CC, protein phosphatase 3, catalytic subunit, gamma isozyme
NCBI Gene ID		5533
neXtProt AC		NX_P48454
Human Synonyms		CALNA3, CNA3, PP2Bgamma
Human Chr (Location)		8p21.3; chr8:22298483-22398657 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(2)

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Function

calmodulin binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	24

cDNA source data(38)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(38) cDNA(38)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000022092 (Evidence)
Entrez Gene	19057 (Evidence)
UniGene	439683
NIA Mouse Gene Index	U035743
EC	3.1.3.16
Consensus CDS Project	CCDS36968.1
International Mouse Knockout Project Status	Ppp3cc

Sequences

Length	Strain/Species
genomic	19057	NCBI Gene Model | MGI Sequence Detail	71552	C57BL/6J
transcript	NM_008915	RefSeq | MGI Sequence Detail	1948	C57BL/6
polypeptide	P48455	UniProt | EBI | MGI Sequence Detail	513	Not Applicable

All sequences(18) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(300 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004843	Metallophosphoesterase domain
InterPro	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Protein Ontology	PR:000013149	serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

Graphical View of Protein Domain Structure

References

(Earliest) J:32280 Kincaid RL, et al., Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods. J Biol Chem. 1990 Jul 5;265(19):11312-9
(Latest) J:190647 Oshima S, et al., Elevated expression of calcineurin subunits during active mineralization of developing mouse molar teeth. Eur J Oral Sci. 2012 Oct;120(5):386-94
All references(32)

Other accession IDs

MGD-MRK-1738, MGD-MRK-35623