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Ppp3cc Gene Detail
Summary
  • Symbol
    Ppp3cc
  • Name
    protein phosphatase 3, catalytic subunit, gamma isoform
  • Synonyms
    Calnc, PP2BA gamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:107162
    NCBI Gene: 19057
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70455314-70526920 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    385 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107162
 protein coding gene Chr14:70455314-70526979 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021534
 protein coding gene Chr14:64846132-64932622 (-)
A/J MGP_AJ_G0021493
 protein coding gene Chr14:63481708-63554216 (-)
AKR/J MGP_AKRJ_G0021469
 protein coding gene Chr14:65385928-65460577 (-)
BALB/cJ MGP_BALBcJ_G0021499
 protein coding gene Chr14:63246530-63318181 (-)
C3H/HeJ MGP_C3HHeJ_G0021276
 protein coding gene Chr14:65096665-65173466 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021938
 protein coding gene Chr14:67760873-67836498 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019478
 protein coding gene Chr14:61318724-61391684 (-)
CAST/EiJ MGP_CASTEiJ_G0020793
 protein coding gene Chr14:61684259-61761821 (-)
CBA/J MGP_CBAJ_G0021243
 protein coding gene Chr14:69879355-69962838 (-)
DBA/2J MGP_DBA2J_G0021366
 protein coding gene Chr14:62864731-62936949 (-)
FVB/NJ MGP_FVBNJ_G0021345
 protein coding gene Chr14:62293093-62364869 (-)
LP/J MGP_LPJ_G0021437
 protein coding gene Chr14:66096520-66174171 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021374
 protein coding gene Chr14:68791797-68866932 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021962
 protein coding gene Chr14:64647102-64722069 (-)
PWK/PhJ MGP_PWKPhJ_G0020537
 protein coding gene Chr14:59627021-59702239 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020370
 protein coding gene Chr14:60578574-60652773 (-)
WSB/EiJ MGP_WSBEiJ_G0020846
 protein coding gene Chr14:64956105-65034142 (-)



Homology
more
  • Human Ortholog
    PPP3CC, protein phosphatase 3 catalytic subunit gamma
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP3CC, protein phosphatase 3 catalytic subunit gamma
  • Synonyms
    CALNA3, CNA3, PP2Bgamma
  • Links
    NCBI Gene ID: 5533
    neXtProt AC: NX_P48454
    UniProt: P48454

  • Chr Location
    8p21.3; chr8:22440819-22541142 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PPP3CC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility due to reduced hyperactivated sperm motility and midpiece rigidity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    19
  • cDNA Data
    37
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022092 Ensembl Gene Model | MGI Sequence Detail 71607 C57BL/6J ±  kb
    transcript ENSMUST00000228911 Ensembl | MGI Sequence Detail 1836 Not Applicable  
    polypeptide ENSMUSP00000153725 Ensembl | MGI Sequence Detail 522 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013149 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
      (term hierarchy)
    • EC
      3.1.3.16
    • InterPro Domains
      IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
      IPR029052 Metallo-dependent phosphatase-like
      IPR043360 PP2B
      IPR041751 PP2B, metallophosphatase domain
      IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 37
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1738, MGD-MRK-35623
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 5
      Gene Ontology 16
      Phenotypes 11
    • Earliest
      J:32280 Kincaid RL, et al., Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods. J Biol Chem. 1990 Jul 5;265(19):11312-9
    • Latest
      J:333720 Ambrozkiewicz MC, et al., The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc. Mol Psychiatry. 2021 Jun;26(6):1980-1995
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory