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Ppp3cc Gene Detail
Summary
  • Symbol
    Ppp3cc
  • Name
    protein phosphatase 3, catalytic subunit, gamma isoform
  • Synonyms
    Calnc, PP2BA gamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:107162
    NCBI Gene: 19057
  • Gene Overview
    MyGene.info: PPP3CC
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:70217865-70289471 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      71607 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.30 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PPP3CC, protein phosphatase 3 catalytic subunit gamma
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPP3CC, protein phosphatase 3 catalytic subunit gamma
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CALNA3, CNA3, PP2Bgamma
  • Links
    NCBI Gene ID: 5533
    neXtProt AC: NX_P48454
    UniProt: P48454

  • Chr Location
    8p21.3; chr8:22440970-22541466 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility due to reduced hyperactivated sperm motility and midpiece rigidity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022092 Ensembl Gene Model | MGI Sequence Detail 71607 C57BL/6J ±  kb
    transcript ENSMUST00000228911 Ensembl | MGI Sequence Detail 1836 Not Applicable  
    polypeptide ENSMUSP00000153725 Ensembl | MGI Sequence Detail 522 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      385 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013149 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
    • EC
    • InterPro Domains
      IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
      IPR029052 Metallo-dependent phosphatase-like
      IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 37

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1738, MGD-MRK-35623
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:32280 Kincaid RL, et al., Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods. J Biol Chem. 1990 Jul 5;265(19):11312-9
    • Latest
      J:256956 Brinegar AE, et al., Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions. Elife. 2017 Aug 11;6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory