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Hmx2 Gene Detail
Summary
  • Symbol
    Hmx2
  • Name
    H6 homeobox 2
  • Synonyms
    Nkx5-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107159
    NCBI Gene: 15372
Location & Maps
more
  • Sequence Map
    Chr7:131548773-131558014 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9242 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HMX2, H6 family homeobox 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HMX2, H6 family homeobox 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    H6L, Nkx5-2
  • Links
    NCBI Gene ID: 3167
    neXtProt AC: NX_A2RU54

  • Chr Location
    10q26.13; chr10:123142421-123150672 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 24625
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: HMX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
Homozygous disruption of this gene results behavioral abnormalities, such as hyperactivity, head tilting and circling, as well as abnormal vestibular morphogenesis, including severe dysgenesis of all three semicircular ducts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037287 VEGA Gene Model | MGI Sequence Detail 9242 C57BL/6J ±  kb
transcript OTTMUST00000116861 VEGA | MGI Sequence Detail 1546 Not Applicable  
polypeptide OTTMUSP00000065262 VEGA | MGI Sequence Detail 273 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    16 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 16
    Genomic 5
    cDNA 10
    Other 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-12896, MGD-MRK-35620
References
more
  • Summaries
    All 46
    Developmental Gene Expression 25
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:17126 Bober E, et al., A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development. Dev Biol. 1994 Mar;162(1):288-303
  • Latest
    J:224836 Hoch RV, et al., OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum. Cell Rep. 2015 Jul 21;12(3):482-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory