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Hmx2
Gene Detail
Symbol

Name
ID
Hmx2
H6 homeobox 2
MGI:107159
Synonyms
Nkx5-2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
74.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:131548773-131556589 bp, + strand
From VEGA annotation of GRCm38

  7817 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:24625  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Hmx2

Human
homologs
Human Homolog HMX2, H6 family homeobox 2
NCBI Gene ID 3167
neXtProt AC  NX_A2RU54
Human Synonyms  H6L, Nkx5-2
Human Chr (Location)  10q26.13; chr10:123142421-123150672 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Homozygous disruption of this gene results behavioral abnormalities, such as hyperactivity, head tilting and circling, as well as abnormal vestibular morphogenesis, including severe dysgenesis of all three semicircular ducts.
 
Interactions
Hmx2 interacts with 124 markers (Mir7-1, Mir15a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process brain development, cell differentiation, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (174)    Tissues (116)    Images (76)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 127
In situ reporter (knock in) 46
RNase protection 1
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(5) cDNA(10) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000037287 (Evidence)
Ensembl Gene ModelENSMUSG00000050100 (Evidence)
Entrez Gene15372 (Evidence)
UniGene303357
DFCITC1592848
DoTSDT.87036353, DT.94223756
Consensus CDS ProjectCCDS21918.1
International Mouse Knockout Project StatusHmx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037287 VEGA Gene Model | MGI Sequence Detail 7817 C57BL/6J ±  kb
transcript OTTMUST00000116861 VEGA | MGI Sequence Detail 1546 Not Applicable 
polypeptide OTTMUSP00000065262 VEGA | MGI Sequence Detail 273 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008647 homeobox protein HMX2
References
(Earliest) J:17126 Bober E, et al., A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development. Dev Biol. 1994 Mar;162(1):288-303
(Latest) J:204486 Zheng S, et al., A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing. Genome Res. 2013 Jun;23(6):998-1007
All references(47)
Other
accession IDs
MGD-MRK-12896, MGD-MRK-35620

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory