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Hmx2 Gene Detail
Summary
  • Symbol
    Hmx2
  • Name
    H6 homeobox 2
  • Synonyms
    Nkx5-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107159
    NCBI Gene: 15372
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:131150502-131159743 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 74.34 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107159
protein coding gene Chr7:131150486-131159743 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033107
protein coding gene Chr7:136185086-136195786 (+)
A/J MGP_AJ_G0033089
protein coding gene Chr7:132462302-132470116 (+)
AKR/J MGP_AKRJ_G0033021
protein coding gene Chr7:135970380-135978204 (+)
BALB/cJ MGP_BALBcJ_G0033090
protein coding gene Chr7:132142066-132150607 (+)
C3H/HeJ MGP_C3HHeJ_G0032804
protein coding gene Chr7:135821065-135828880 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033601
protein coding gene Chr7:141386929-141398004 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030572
protein coding gene Chr7:133726321-133734115 (+)
CAST/EiJ MGP_CASTEiJ_G0032134
protein coding gene Chr7:127676066-127685794 (+)
CBA/J MGP_CBAJ_G0032777
protein coding gene Chr7:146246320-146254126 (+)
DBA/2J MGP_DBA2J_G0032929
protein coding gene Chr7:130441001-130449384 (+)
FVB/NJ MGP_FVBNJ_G0032882
protein coding gene Chr7:130302195-130309961 (+)
LP/J MGP_LPJ_G0033023
protein coding gene Chr7:137675094-137685630 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032914
protein coding gene Chr7:147183666-147191504 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033621
protein coding gene Chr7:134965161-134972891 (+)
PWK/PhJ MGP_PWKPhJ_G0031840
protein coding gene Chr7:123471781-123479602 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031686
protein coding gene Chr7:121749729-121757526 (+)
WSB/EiJ MGP_WSBEiJ_G0032245
protein coding gene Chr7:135867491-135875209 (+)



Homology
more
  • Human Ortholog
    HMX2, H6 family homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMX2, H6 family homeobox 2
  • Synonyms
    H6L, Nkx5-2
  • Links
    NCBI Gene ID: 3167
    neXtProt AC: NX_A2RU54
    UniProt: A2RU54

  • Chr Location
    10q26.13; chr10:123148136-123150672 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene results behavioral abnormalities, such as hyperactivity, head tilting and circling, as well as abnormal vestibular morphogenesis, including severe dysgenesis of all three semicircular ducts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050100 Ensembl Gene Model | MGI Sequence Detail 9242 C57BL/6J ±  kb
    transcript ENSMUST00000183219 Ensembl | MGI Sequence Detail 1546 Not Applicable  
    polypeptide ENSMUSP00000138799 Ensembl | MGI Sequence Detail 273 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 5
      cDNA 12
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-12896, MGD-MRK-35620
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 31
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:17126 Bober E, et al., A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development. Dev Biol. 1994 Mar;162(1):288-303
    • Latest
      J:295412 Kim DW, et al., The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development. Nat Commun. 2020 Aug 31;11(1):4360

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory