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Hmx2
Gene Detail
Symbol

Name
ID
Hmx2
H6 homeobox 2
MGI:107159
Synonyms
Nkx5-2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
74.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:131548773-131556589 bp, + strand
From VEGA annotation of GRCm38

  7817 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:24625  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HMX2
Gene Tree: Hmx2

Human
homologs
HMX2, H6 family homeobox 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3167
neXtProt AC: NX_A2RU54

Human Synonyms: H6L, Nkx5-2

Human Chr (Location): 10q26.13; chr10:123142421-123150672 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Homozygous disruption of this gene results behavioral abnormalities, such as hyperactivity, head tilting and circling, as well as abnormal vestibular morphogenesis, including severe dysgenesis of all three semicircular ducts.
 
Interactions
Hmx2 interacts with 124 markers (Mir7-1, Mir15a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process brain development, cell differentiation, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (174)    Tissues (116)    Images (76)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 127
In situ reporter (knock in) 46
RNase protection 1
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hmx2 ; ZFIN hmx2    NEW 
Molecular
reagents
All nucleic(16) Genomic(5) cDNA(10) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000037287 (Evidence)
Ensembl Gene Model ENSMUSG00000050100 (Evidence)
Entrez Gene 15372 (Evidence)
UniGene 303357
DFCI TC1592848
DoTS DT.87036353, DT.94223756
Consensus CDS Project CCDS21918.1
International Mouse Phenotyping Consortium Status Hmx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037287 VEGA Gene Model | MGI Sequence Detail 7817 C57BL/6J ±  kb
transcript OTTMUST00000116861 VEGA | MGI Sequence Detail 1546 Not Applicable 
polypeptide OTTMUSP00000065262 VEGA | MGI Sequence Detail 273 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeobox domain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008647 homeobox protein HMX2
References
(Earliest) J:17126 Bober E, et al., A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development. Dev Biol. 1994 Mar;162(1):288-303
(Latest) J:204486 Zheng S, et al., A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing. Genome Res. 2013 Jun;23(6):998-1007
All references(46)
Other
accession IDs
MGD-MRK-12896, MGD-MRK-35620

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory