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Aff3 Gene Detail
Summary
  • Symbol
    Aff3
  • Name
    AF4/FMR2 family, member 3
  • Synonyms
    3222402O04Rik, Laf4, LAF-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:106927
    NCBI Gene: 16764
  • Gene Overview
    MyGene.info: AFF3
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:38175393-38628333 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 16.58 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4322 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106927
protein coding gene Chr1:38175393-38664955 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015950
protein coding gene Chr1:36843514-37339104 (-)
A/J MGP_AJ_G0015934
protein coding gene Chr1:35833839-36330266 (-)
AKR/J MGP_AKRJ_G0015889
protein coding gene Chr1:36323687-36819557 (-)
BALB/cJ MGP_BALBcJ_G0015888
protein coding gene Chr1:35484445-35972576 (-)
C3H/HeJ MGP_C3HHeJ_G0015721
protein coding gene Chr1:36550505-37057475 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016341
protein coding gene Chr1:38436160-38947418 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014063
protein coding gene Chr1:32806875-33287377 (-)
CAST/EiJ MGP_CASTEiJ_G0015302
protein coding gene Chr1:36411384-36932001 (-)
CBA/J MGP_CBAJ_G0015693
protein coding gene Chr1:39495674-40017966 (-)
DBA/2J MGP_DBA2J_G0015794
protein coding gene Chr1:35129940-35621790 (-)
FVB/NJ MGP_FVBNJ_G0015796
protein coding gene Chr1:34658712-35145850 (-)
LP/J MGP_LPJ_G0015864
protein coding gene Chr1:37191027-37692531 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015816
protein coding gene Chr1:41642733-42157410 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016388
protein coding gene Chr1:36395288-36899188 (-)
PWK/PhJ MGP_PWKPhJ_G0015085
protein coding gene Chr1:34919373-35410948 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014867
protein coding gene Chr1:36345326-36834801 (-)
WSB/EiJ MGP_WSBEiJ_G0015364
protein coding gene Chr1:36356852-36865255 (-)



Homology
more
  • Human Ortholog
    AFF3, AF4/FMR2 family member 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AFF3, AF4/FMR2 family member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LAF4, MLLT2-like
  • Links
    NCBI Gene ID: 3899
    neXtProt AC: NX_P51826
    UniProt: P51826

  • Chr Location
    2q11.2; chr2:99545861-100142583 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1718
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AFF3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16764 NCBI Gene Model | MGI Sequence Detail 452941 C57BL/6J ±  kb
    transcript NM_001290814 RefSeq | MGI Sequence Detail 7251 C57BL/6  
    polypeptide P51827 UniProt | EBI | MGI Sequence Detail 1254 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR007797 Transcription factor AF4/FMR2
    Molecular
    Reagents
    less
    • All nucleic 76
      Genomic 1
      cDNA 73
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-35388, MGI:1918018
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 13
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:30625 Ma C, et al., LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias. Blood. 1996 Jan 15;87(2):734-45
    • Latest
      J:226658 Metsu S, et al., FRA2A is a CGG repeat expansion associated with silencing of AFF3. PLoS Genet. 2014 Apr;10(4):e1004242

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory