Phenotypes Associated with This Genotype

Genotype
MGI:5608405

• Allelic Composition: Aff3^{tm1a(EUCOMM)Wtsi}/Aff3^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Aff3^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0242_2_E12

Data Sources

IMPC Data for Aff3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:211773 )

♀

IMPC - WTSI

craniofacial

abnormal tooth morphology ( J:211773 )

IMPC - WTSI

abnormal incisor morphology ( J:211773 )

♂

IMPC - WTSI

abnormal snout morphology ( J:211773 )

♂

IMPC - WTSI

growth/size/body

abnormal tooth morphology ( J:211773 )

IMPC - WTSI

abnormal incisor morphology ( J:211773 )

♂

IMPC - WTSI

abnormal snout morphology ( J:211773 )

♂

IMPC - WTSI

homeostasis/metabolism

decreased circulating fructosamine level ( J:211773 )

♂

IMPC - WTSI

increased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - WTSI

decreased circulating serum albumin level ( J:211773 )

IMPC - WTSI

increased circulating chloride level ( J:211773 )

♂

IMPC - WTSI

nervous system

enlarged lateral ventricles ( J:317476 )

♂ • in males

decreased corpus callosum size ( J:317476 )

♂ • in males

skeleton

abnormal tooth morphology ( J:211773 )

IMPC - WTSI

abnormal incisor morphology ( J:211773 )

♂

IMPC - WTSI

abnormal vertebral arch morphology ( J:211773 )

IMPC - WTSI

fusion of vertebral arches ( J:211773 )

♀

IMPC - WTSI

vertebral transformation ( J:211773 )

♀

IMPC - WTSI

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
KINSSHIP syndrome		DOID:0112383	OMIM:619297	J:317476