Tll1
Gene Detail

Symbol Name ID

Tll1 tolloid-like MGI:106923

Synonyms

Tll-1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

32.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr8:64014770-64205993 bp, - strand From NCBI annotation of GRCm38   191224 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49202  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tolloid-like protein
Gene Tree: Tll1

Human homologs

Human Homolog		TLL1, tolloid-like 1
NCBI Gene ID		7092
neXtProt AC		NX_O43897
Human Synonyms		ASD6, TLL
Human Chr (Location)		4q32-q33; chr4:166794410-167025609 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TLL1

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice are embryonic lethal with death at midgestation from cardiac failure. Cardiac defects include incomplete formation of the ventricular septum and abnormal positioning of the heart and aorta.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cell differentiation, multicellular organismal development, ...
Component	extracellular region
Function	calcium ion binding, collagen binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (66)    Tissues (57)    Images (19)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 23, 26, 28

Assay Type	Results
RNA in situ	56
RT-PCR	10

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) Genomic(1) cDNA(8) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000053626 (Evidence)
Entrez Gene	21892 (Evidence)
DFCI	TC1588560, TC1704765
DoTS	DT.91334491
NIA Mouse Gene Index	U029871
EC	3.4.24.-
Consensus CDS Project	CCDS40352.1
International Mouse Knockout Project Status	Tll1

Sequences

Length	Strain/Species
genomic	21892	NCBI Gene Model | MGI Sequence Detail	191224	C57BL/6J
transcript	NM_009390	RefSeq | MGI Sequence Detail	4928	Not Specified
polypeptide	Q62381	UniProt | EBI | MGI Sequence Detail	1013	Not Applicable

All sequences(17) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(951 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015446	Bone morphogenetic protein 1/tolloid-like protein
InterPro	IPR000859	CUB domain
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR001506	Peptidase M12A, astacin
InterPro	IPR006026	Peptidase, metallopeptidase
Protein Ontology	PR:000016379	tolloid-like protein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:33379 Takahara K, et al., Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1. Genomics. 1996 1;34(2):157-65
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)

Other accession IDs

MGD-MRK-35384