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Tll1 Gene Detail
Summary
  • Symbol
    Tll1
  • Name
    tolloid-like
  • Synonyms
    Tll-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106923
    NCBI Gene: 21892
  • Gene Overview
    MyGene.info: TLL1
Location & Maps
more
  • Sequence Map
    Chr8:64014770-64205993 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      191224 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TLL1, tolloid like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TLL1, tolloid like 1
    Orthology source: HomoloGene
  • Synonyms
    ASD6, TLL
  • Links
    NCBI Gene ID: 7092
    neXtProt AC: NX_O43897

  • Chr Location
    4q32.3; chr4:165873238-166105178 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TLL1 associations

Human Disease Mouse Models
       Atrial Septal Defect 6; ASD6   OMIM: 613087
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    46 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Tll1
  • Incidental Mutations
Homozygous null mice are embryonic lethal with death at midgestation from cardiac failure. Cardiac defects include incomplete formation of the ventricular septum and abnormal positioning of the heart and aorta.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053626 Ensembl Gene Model | MGI Sequence Detail 191224 C57BL/6J ±  kb
transcript ENSMUST00000066166 Ensembl | MGI Sequence Detail 4928 Not Applicable  
polypeptide ENSMUSP00000070560 Ensembl | MGI Sequence Detail 1013 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1162 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    Genomic 1
    cDNA 8
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-35384
References
more
  • Summaries
    All 38
    Developmental Gene Expression 7
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:33379 Takahara K, et al., Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1. Genomics. 1996 1;34(2):157-65
  • Latest
    J:229467 Zhang KK, et al., Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation. Hum Mol Genet. 2016 Mar 15;25(6):1140-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory