About   Help   FAQ
Tll1 Gene Detail
Summary
  • Symbol
    Tll1
  • Name
    tolloid-like
  • Synonyms
    b2b2476Clo, Tll-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106923
    NCBI Gene: 21892
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:64467965-64659305 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 32.19 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1162 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106923
 protein coding gene Chr8:64466132-64659305 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033641
 protein coding gene Chr8:64008299-64222363 (-)
A/J MGP_AJ_G0033623
 protein coding gene Chr8:61293592-61497213 (-)
AKR/J MGP_AKRJ_G0033548
 protein coding gene Chr8:63067917-63249948 (-)
BALB/cJ MGP_BALBcJ_G0033619
 protein coding gene Chr8:61575159-61775949 (-)
C3H/HeJ MGP_C3HHeJ_G0033329
 protein coding gene Chr8:63774326-63981171 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034136
 protein coding gene Chr8:66397757-66610340 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031083
 protein coding gene Chr8:56374460-56574706 (-)
CAST/EiJ MGP_CASTEiJ_G0032654
 protein coding gene Chr8:63217083-63443871 (-)
CBA/J MGP_CBAJ_G0033307
 protein coding gene Chr8:68867283-69096206 (-)
DBA/2J MGP_DBA2J_G0033461
 protein coding gene Chr8:61052854-61257420 (-)
FVB/NJ MGP_FVBNJ_G0033402
 protein coding gene Chr8:60339392-60533454 (-)
LP/J MGP_LPJ_G0033549
 protein coding gene Chr8:64030221-64239757 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033446
 protein coding gene Chr8:71357783-71637317 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034154
 protein coding gene Chr8:63336132-63549603 (-)
PWK/PhJ MGP_PWKPhJ_G0032363
 protein coding gene Chr8:60442433-60645603 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032199
 protein coding gene Chr8:62293552-62509406 (-)
WSB/EiJ MGP_WSBEiJ_G0032771
 protein coding gene Chr8:63708489-63918240 (-)



Homology
more
  • Human Ortholog
    TLL1, tolloid like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLL1, tolloid like 1
  • Synonyms
    ASD6, TLL
  • Links
    NCBI Gene ID: 7092
    neXtProt AC: NX_O43897
    UniProt: O43897

  • Chr Location
    4q32.3; chr4:165873237-166104457 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human TLL1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    49 phenotypes from multigenic genotypes
    12 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are embryonic lethal with death at midgestation from cardiac failure. Cardiac defects include incomplete formation of the ventricular septum and abnormal positioning of the heart and aorta.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    63
  • cDNA Data
    8
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053626 Ensembl Gene Model | MGI Sequence Detail 191341 C57BL/6J ±  kb
    transcript ENSMUST00000066166 Ensembl | MGI Sequence Detail 4767 Not Applicable  
    polypeptide ENSMUSP00000070560 Ensembl | MGI Sequence Detail 1013 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 2
      cDNA 10
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35384, MGI:5560785
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:21883 Takahara K, et al., Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues. J Biol Chem. 1994 Dec 23;269(51):32572-8
    • Latest
      J:294589 Eshed-Eisenbach Y, et al., Precise Spatiotemporal Control of Nodal Na(+) Channel Clustering by Bone Morphogenetic Protein-1/Tolloid-like Proteinases. Neuron. 2020 Jun 3;106(5):806-815.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory