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Tll1
Gene Detail
Symbol

Name
ID
Tll1
tolloid-like
MGI:106923
Synonyms
Tll-1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
32.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr8:64014770-64205993 bp, - strand
From Ensembl annotation of GRCm38

  191224 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49202  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tolloid-like protein
Gene Tree: Tll1

Human
homologs
Human Homolog TLL1, tolloid-like 1
NCBI Gene ID 7092
neXtProt AC  NX_O43897
Human Synonyms  ASD6, TLL
Human Chr (Location)  4q32-q33; chr4:165873238-166105178 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TLL1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are embryonic lethal with death at midgestation from cardiac failure. Cardiac defects include incomplete formation of the ventricular septum and abnormal positioning of the heart and aorta.
 
Interactions
Tll1 interacts with 210 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell differentiation, multicellular organismal development, ...
Component extracellular region
Function calcium ion binding, collagen binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (66)    Tissues (57)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 56
RT-PCR 10
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(8) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000053626 (Evidence)
Entrez Gene21892 (Evidence)
DFCITC1704765, TC1588560
DoTSDT.91334491
NIA Mouse Gene IndexU029871
EC3.4.24.-
Consensus CDS ProjectCCDS40352.1
International Mouse Knockout Project StatusTll1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053626 Ensembl Gene Model | MGI Sequence Detail 191224 C57BL/6J ±  kb
transcript ENSMUST00000066166 Ensembl | MGI Sequence Detail 4928 Not Applicable 
polypeptide ENSMUSP00000070560 Ensembl | MGI Sequence Detail 1013 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(6) UniProt(3)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(1172 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015446 Bone morphogenetic protein 1/tolloid-like protein
InterPro IPR000859 CUB domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001506 Peptidase M12A, astacin
InterPro IPR006026 Peptidase, metallopeptidase
Protein Ontology PR:000016379 tolloid-like protein 1
References
(Earliest) J:33379 Takahara K, et al., Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1. Genomics. 1996 1;34(2):157-65
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)
Other
accession IDs
MGD-MRK-35384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory