Gene Expression Literature Summary

• Symbol: Tll1
• Name: tolloid-like
• ID: MGI:106923

9 matching records from 9 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E7.5	E8.5	E9	E9.5	E10.5	E11	E11.5	E12.5	E13.5	E14.5	E15	E15.5	E17	E18.5	P
In situ RNA (section)		2	1	1	2	2		2	2	2	1		2			3
In situ RNA (whole mount)					1	1
Northern blot	1						1					1		1		1
RT-PCR			1		3			1		1	1		1		2	1
RNase protection																1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tll1  tolloid-like   (Synonyms: b2b2476Clo, Tll-1)
Results	Reference
15*	J:54910 Clark TG, Conway SJ, Scott IC, Labosky PA, Winnier G, Bundy J , Hogan BL , Greenspan DS, The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart. Development. 1999 Jun;126(12):2631-42
1	J:157259 Ikeya M, Fukushima K, Kawada M, Onishi S, Furuta Y, Yonemura S, Kitamura T, Nosaka T, Sasai Y, Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors. Dev Biol. 2010 Jan 15;337(2):405-14
1*	J:356545 Li X, Madison BB, Zacharias W, Kolterud A, States D, Gumucio DL, Deconvoluting the intestine: molecular evidence for a major role of the mesenchyme in the modulation of signaling cross talk. Physiol Genomics. 2007 May 11;29(3):290-301
2	J:372660 Lupu IE, Grainger DE, Kirschnick N, Weischer S, Zhao E, Martinez-Corral I, Schoofs H, Vanhollebeke M, Jones G, Godwin J, Forrow A, Lahmann I, Riley PR, Zobel T, Alitalo K, Makinen T, Kiefer F, Stone OA, Direct specification of lymphatic endothelium from mesenchymal progenitors. Nat Cardiovasc Res. 2025 Jan;4(1):45-63
2*	J:148787 Sabirzhanova I, Sabirzhanov B, Bjordahl J, Brandt J, Jay PY, Clark TG, Activation of Tolloid-like 1 gene expression by the cardiac specific homeobox gene Nkx2-5. Dev Growth Differ. 2009 May;51(4):403-10
3	J:57658 Scott IC, Blitz IL, Pappano WN, Imamura Y, Clark TG, Steiglitz BM, Thomas CL, Maas SA, Takahara K, Cho KW, Greenspan DS, Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis. Dev Biol. 1999 Sep 15;213(2):283-300
1*	J:61391 Scott IC, Steiglitz BM, Clark TG, Pappano WN, Greenspan DS, Spatiotemporal expression patterns of mammalian chordin during postgastrulation embryogenesis and in postnatal brain. Dev Dyn. 2000 Apr;217(4):449-56
13	J:33379 Takahara K, Brevard R, Hoffman GG, Suzuki N, Greenspan DS, Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1. Genomics. 1996 1;34(2):157-65
1*	J:229467 Zhang KK, Xiang M, Zhou L, Liu J, Curry N, Heine Suner D, Garcia-Pavia P, Zhang X, Wang Q, Xie L, Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation. Hum Mol Genet. 2016 Mar 15;25(6):1140-51