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Vdac1 Gene Detail
Summary
  • Symbol
    Vdac1
  • Name
    voltage-dependent anion channel 1
  • Synonyms
    Vdac5
  • Feature Type
    protein coding gene
  • IDs
    MGI:106919
    NCBI Gene: 22333
  • Gene Overview
    MyGene.info: VDAC1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:52360862-52389397 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 31.86 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106919
protein coding gene Chr11:52360860-52389397 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018284
protein coding gene Chr11:51678002-51707186 (+)
A/J MGP_AJ_G0018253
protein coding gene Chr11:49740331-49768778 (+)
AKR/J MGP_AKRJ_G0018223
protein coding gene Chr11:51343770-51372298 (+)
BALB/cJ MGP_BALBcJ_G0018224
protein coding gene Chr11:50071300-50100539 (+)
C3H/HeJ MGP_C3HHeJ_G0018035
protein coding gene Chr11:51321197-51350049 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018676
protein coding gene Chr11:53251195-53280754 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016326
protein coding gene Chr11:47258455-47273404 (+)
CAST/EiJ MGP_CASTEiJ_G0017600
protein coding gene Chr11:51354025-51387120 (+)
CBA/J MGP_CBAJ_G0018010
protein coding gene Chr11:55758215-55789467 (+)
DBA/2J MGP_DBA2J_G0018120
protein coding gene Chr11:49471122-49501339 (+)
FVB/NJ MGP_FVBNJ_G0018112
protein coding gene Chr11:49132943-49162694 (+)
LP/J MGP_LPJ_G0018194
protein coding gene Chr11:52092954-52126154 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018136
protein coding gene Chr11:57104678-57140589 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018718
protein coding gene Chr11:51394613-51426515 (+)
PWK/PhJ MGP_PWKPhJ_G0017375
protein coding gene Chr11:49966545-49996147 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017170
protein coding gene Chr11:51182137-51213299 (+)
WSB/EiJ MGP_WSBEiJ_G0017647
protein coding gene Chr11:51016310-51050116 (+)



Homology
more
  • Human Ortholog
    VDAC1, voltage dependent anion channel 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VDAC1, voltage dependent anion channel 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PORIN, VDAC-1
  • Links
    NCBI Gene ID: 7416
    neXtProt AC: NX_P21796
    UniProt: P21796

  • Chr Location
    5q31.1; chr5:133971875-134070987 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 107244
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: VDAC1
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit approximately 60% embryonic mortality, with loss occurring at embryonic day 10.5-11.5. Survivors exhibit defective cued fear conditioning and spatial learning. Heterozygotes also exhibit about 12% prenatal mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22333 NCBI Gene Model | MGI Sequence Detail 28536 C57BL/6J ±  kb
transcript NM_001362693 RefSeq | MGI Sequence Detail 2108 C57BL/6  
polypeptide Q60932 UniProt | EBI | MGI Sequence Detail 296 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 3
    cDNA 16

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-35380, MGI:2144363
References
more
  • Summaries
    All 84
    Developmental Gene Expression 12
    Gene Ontology 17
    Phenotypes 20
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:255071 Zhou H, et al., Mff-Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS-Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation-Involved mPTP Opening. J Am Heart Assoc. 2017 Mar 13;6(3)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory