Vdac1
Gene Detail

Symbol Name ID

Vdac1 voltage-dependent anion channel 1 MGI:106919

Synonyms

Vdac5

Feature Type

protein coding gene

Genetic Map

Chromosome 11

31.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:52360860-52389397 bp, + strand From VEGA annotation of GRCm38   28538 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:107244  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: porin
Gene Tree: Vdac1

Human homologs

Human Homolog		VDAC1, voltage-dependent anion channel 1
NCBI Gene ID		7416
neXtProt AC		NX_P21796
Human Synonyms		PORIN, VDAC-1
Human Chr (Location)		5q31; chr5:133307566-133340824 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(132) : Targeted(4) Gene trapped(128)
 

Homozygous null mutants exhibit approximately 60% embryonic mortality, with loss occurring at embryonic day 10.5-11.5. Survivors exhibit defective cued fear conditioning and spatial learning. Heterozygotes also exhibit about 12% prenatal mortality.

 

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	anion transport, apoptotic process, ...
Component	integral to membrane, membrane, ...
Function	anion channel activity, nucleotide binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (64)    Tissues (49)    Images (16)
Theiler Stages: 10, 14, 15, 18, 19, 20, 21, 22, 23, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	34
Western blot	18

cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(3) cDNA(15)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000005626 (Evidence)
Ensembl Gene Model	ENSMUSG00000020402 (Evidence)
Entrez Gene	22333 (Evidence)
DFCI	TC1573889, TC1745978
DoTS	DT.101273015, DT.101384643, DT.101384646, DT.496254, DT.94383302
NIA Mouse Gene Index	U012584, U253148
PDB	3EMN
Consensus CDS Project	CCDS24671.1
International Mouse Knockout Project Status	Vdac1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005626	VEGA Gene Model | MGI Sequence Detail	28538	C57BL/6J
transcript	OTTMUST00000047822	VEGA | MGI Sequence Detail	891	Not Applicable
polypeptide	OTTMUSP00000021749	VEGA | MGI Sequence Detail	296	Not Applicable

All sequences(67) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(82 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001925	Porin, eukaryotic type
Protein Ontology	PR:000017280	voltage-dependent anion-selective channel protein 1

References

(Earliest) J:32840 Sampson MJ, et al., Isolation, characterization, and mapping of two mouse mitochondrial voltage-dependent anion channel isoforms. Genomics. 1996 Apr 15;33(2):283-8
(Latest) J:192731 Ha SD, et al., Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. Mol Cell Biol. 2012 Dec;32(23):4846-60
All references(67)

Other accession IDs

MGD-MRK-35380, MGI:2144363