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Zic1 Gene Detail
Summary
  • Symbol
    Zic1
  • Name
    zinc finger protein of the cerebellum 1
  • Synonyms
    odd-paired homolog
  • Feature Type
    protein coding gene
  • IDs
    MGI:106683
    NCBI Gene: 22771
  • Gene Overview
    MyGene.info: ZIC1
Location & Maps
more
  • Sequence Map
    Chr9:91358058-91365810 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7753 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 48.26 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ZIC1, Zic family member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZIC1, Zic family member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRS6, ZIC, ZNF201
  • Links
    NCBI Gene ID: 7545
    neXtProt AC: NX_Q15915

  • Chr Location
    3q24; chr3:147409394-147416719 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2562
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: ZIC1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Zic1 mouse models; 1 with human ZIC1 associations

Human Disease Mouse Models
       Dandy-Walker Syndrome; DWS   OMIM: 220200 View 1 model
       Craniosynostosis 6; CRS6   OMIM: 616602
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    3
  • Transgenic
    2
  • Genomic Mutations
    1 involving Zic1
Homozygous mutants show cerebellar hypoplasia with a missing lobule of the anterior lobe. Newborn pups suckle poorly. 50% die within one day of birth and almost all die within 3 weeks; longer survivors show marked ataxia and exhibit tonic convulsions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020412 VEGA Gene Model | MGI Sequence Detail 7753 C57BL/6J ±  kb
transcript OTTMUST00000048471 VEGA | MGI Sequence Detail 5606 Not Applicable  
polypeptide OTTMUSP00000022224 VEGA | MGI Sequence Detail 447 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    10 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017665 zinc finger protein ZIC 1
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
less
  • All nucleic 29
    Genomic 2
    cDNA 18
    Primer pair 7
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-35142
References
more
  • Summaries
    All 120
    Developmental Gene Expression 82
    Diseases 2
    Gene Ontology 13
    Phenotypes 15
  • Earliest
    J:31270 Aruga J, et al., A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J Neurochem. 1994 Nov;63(5):1880-90
  • Latest
    J:230758 Twigg SR, et al., Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability. Am J Hum Genet. 2015 Sep 3;97(3):378-88

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory