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Zic1
Gene Detail
Symbol

Name
ID
Zic1
zinc finger protein of the cerebellum 1
MGI:106683
Synonyms
odd-paired homolog
Feature Type
protein coding gene
Genetic Map
Chromosome 9
48.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:91358058-91365810 bp, - strand
From VEGA annotation of GRCm38

  7753 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2562  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ZIC1
Gene Tree: Zic1

Human
homologs
ZIC1, Zic family member 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7545
neXtProt AC: NX_Q15915

Human Synonyms: ZIC, ZNF201

Human Chr (Location): 3q24; chr3:147409394-147416719 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Homozygous mutants show cerebellar hypoplasia with a missing lobule of the anterior lobe. Newborn pups suckle poorly. 50% die within one day of birth and almost all die within 3 weeks; longer survivors show marked ataxia and exhibit tonic convulsions.
 
Human Diseases Modeled in Mice Using Zic1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Zic1 interacts with 397 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process adult walking behavior, brain development, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (76 records)
Data Summary: Results (306)    Tissues (103)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 288
Northern blot 1
RT-PCR 17
cDNA source data(18)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA ZIC1 ; Xenbase zic1 ; ZFIN zic1    NEW 
Molecular
reagents
All nucleic(28) Genomic(2) cDNA(18) Primer pair(7) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000020412 (Evidence)
Ensembl Gene Model ENSMUSG00000032368 (Evidence)
Entrez Gene 22771 (Evidence)
DFCI TC1581596, TC1714202, TC1646241
DoTS DT.87068403, DT.101201083
Consensus CDS Project CCDS23403.1
International Mouse Phenotyping Consortium Status Zic1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020412 VEGA Gene Model | MGI Sequence Detail 7753 C57BL/6J ±  kb
transcript OTTMUST00000048471 VEGA | MGI Sequence Detail 5606 Not Applicable 
polypeptide OTTMUSP00000022224 VEGA | MGI Sequence Detail 447 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017665 zinc finger protein ZIC 1
References
(Earliest) J:31270 Aruga J, et al., A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J Neurochem. 1994 Nov;63(5):1880-90
(Latest) J:217592 Arnold TD, et al., Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking alphaVbeta8-TGFbeta signaling in the brain. Development. 2014 Dec;141(23):4489-99
All references(114)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-35142

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory