Zic1
Gene Detail

Symbol Name ID

Zic1 zinc finger protein of the cerebellum 1 MGI:106683

Synonyms

odd-paired homolog

Feature Type

protein coding gene

Genetic Map

Chromosome 9

48.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:91358058-91365810 bp, - strand From VEGA annotation of GRCm38   7753 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2562  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Zic1

Human homologs

Human Homolog		ZIC1, Zic family member 1
NCBI Gene ID		7545
neXtProt AC		NX_Q15915
Human Synonyms		ZIC, ZNF201
Human Chr (Location)		3q24; chr3:147127181-147134506 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous mutants show cerebellar hypoplasia with a missing lobule of the anterior lobe. Newborn pups suckle poorly. 50% die within one day of birth and almost all die within 3 weeks; longer survivors show marked ataxia and exhibit tonic convulsions.

 
Human Diseases Modeled Using Mouse Zic1 (2)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	behavior, brain development, ...
Component	cytoplasm, nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (66 records)
Data Summary: Results (294)    Tissues (97)    Images (40)
Theiler Stages: 8, 9, 10, 11, 12, 14, 15, 16, 17, 18, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	276
Northern blot	1
RT-PCR	17

cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(2) cDNA(17) Primer pair(6) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000020412 (Evidence)
Ensembl Gene Model	ENSMUSG00000032368 (Evidence)
Entrez Gene	22771 (Evidence)
DFCI	TC1581596, TC1646241, TC1714202
DoTS	DT.101201083, DT.87068403
Consensus CDS Project	CCDS23403.1
International Mouse Knockout Project Status	Zic1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020412	VEGA Gene Model | MGI Sequence Detail	7753	C57BL/6J
transcript	OTTMUST00000048471	VEGA | MGI Sequence Detail	5606	Not Applicable
polypeptide	OTTMUSP00000022224	VEGA | MGI Sequence Detail	447	Not Applicable

All sequences(39) RefSeq(2) UniProt(4)

Polymorphisms

PCR(1) : SNPs(5 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000017665	zinc finger protein ZIC 1

References

(Earliest) J:31270 Aruga J, et al., A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J Neurochem. 1994 Nov;63(5):1880-90
(Latest) J:192502 Wei B, et al., The onion skin-like organization of the septum arises from multiple embryonic origins to form multiple adult neuronal fates. Neuroscience. 2012 Oct 11;222:110-23
All references(105)

Other accession IDs

MGD-MRK-35142