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Zic1
Gene Detail
 Symbol
Name
ID
Zic1
zinc finger protein of the cerebellum 1
MGI:106683
Synonyms odd-paired homolog
Feature Type protein coding gene
Genetic Map
Chromosome 9
48.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:91358058-91365810 bp, - strand
From VEGA annotation of GRCm38

  7753 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2562  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Zic1

Human
homologs
Human Homolog ZIC1, Zic family member 1
NCBI Gene ID 7545
neXtProt AC  NX_Q15915
Human Synonyms  ZIC, ZNF201
Human Chr (Location)  3q24; chr3:147409394-147416719 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Homozygous mutants show cerebellar hypoplasia with a missing lobule of the anterior lobe. Newborn pups suckle poorly. 50% die within one day of birth and almost all die within 3 weeks; longer survivors show marked ataxia and exhibit tonic convulsions.
 
Human Diseases Modeled Using Mouse Zic1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Zic1 interacts with 398 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process adult walking behavior, brain development, ...
Component cytoplasm, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (74 records)
Data Summary: Results (306)    Tissues (103)    Images (44)
Theiler Stages: 8, 9, 10, 11, 12, 14, 15, 16, 17, 18, 19, 20, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 288
Northern blot 1
RT-PCR 17
cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(2) cDNA(18) Primer pair(7) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000020412 (Evidence)
Ensembl Gene ModelENSMUSG00000032368 (Evidence)
Entrez Gene22771 (Evidence)
DFCITC1581596, TC1646241, TC1714202
DoTSDT.101201083, DT.87068403
Consensus CDS ProjectCCDS23403.1
International Mouse Knockout Project StatusZic1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020412 VEGA Gene Model | MGI Sequence Detail 7753 C57BL/6J ±  kb
transcript OTTMUST00000048471 VEGA | MGI Sequence Detail 5606 Not Applicable 
polypeptide OTTMUSP00000022224 VEGA | MGI Sequence Detail 447 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(4)
Polymorphisms PCR(1) : SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017665 zinc finger protein ZIC 1
References (Earliest) J:31270 Aruga J, et al., A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J Neurochem. 1994 Nov;63(5):1880-90
(Latest) J:206591 Di Giovannantonio LG, et al., Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity. Development. 2014 Jan;141(2):377-88
All references(113)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35142

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory