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Srf
Gene Detail
 Symbol
Name
ID
Srf
serum response factor
MGI:106658
Feature Type protein coding gene
Genetic Map
Chromosome 17
22.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:46546839-46556162 bp, - strand
From NCBI annotation of GRCm38

  9324 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31135  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Srf

Human
homologs
Human Homolog SRF, serum response factor (c-fos serum response element-binding transcription factor)
NCBI Gene ID 6722
neXtProt AC  NX_P11831
Human Synonyms  MCM1
Human Chr (Location)  6p21.1; chr6:43171182-43181506 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(1) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit embryonic lethality, abnormal gastrulation, no mesoderm or primitive streak formation and reduced embryo size.
 
Phenotype Images(3)
Interactions
Srf interacts with 371 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (114 annotations)
Process actin cytoskeleton organization, actin filament organization, ...
Component cytoplasm, nuclear chromatin, ...
Function chromatin binding, chromatin DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (48 records)
Data Summary: Results (227)    Tissues (195)    Images (22)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 191
Western blot 13
RT-PCR 23
cDNA source data(73)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(79) Genomic(2) cDNA(73) Primer pair(4)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000015605 (Evidence)
Entrez Gene20807 (Evidence)
UniGene45044
DFCITC1577357
DoTSDT.531151
NIA Mouse Gene IndexU037861
Consensus CDS ProjectCCDS28831.1
International Mouse Knockout Project StatusSrf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20807 NCBI Gene Model | MGI Sequence Detail 9324 C57BL/6J ±  kb
transcript NM_020493 RefSeq | MGI Sequence Detail 4093 C57BL/6 
polypeptide Q9JM73 UniProt | EBI | MGI Sequence Detail 504 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002100 Transcription factor, MADS-box
Protein Ontology PR:000015613 serum response factor
Graphical View of Protein Domain Structure
References (Earliest) J:34031 Latinkic BV, et al., Promoter function and structure of the growth factor-inducible immediate early gene cyr61. Nucleic Acids Res. 1991 Jun 25;19(12):3261-7
(Latest) J:209602 Li CL, et al., SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons. J Neurosci. 2014 Mar 12;34(11):4027-42
All references(158)
Other
accession IDs
MGD-MRK-35116, MGI:2147041, MGI:2147058

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory