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Srf
Gene Detail
Symbol

Name
ID
Srf
serum response factor
MGI:106658
Feature Type
protein coding gene
Genetic Map
Chromosome 17
22.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:46546839-46556162 bp, - strand
From Ensembl annotation of GRCm38

  9324 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31135  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SRF
Gene Tree: Srf

Human
homologs
SRF, serum response factor (c-fos serum response element-binding transcription factor)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6722
neXtProt AC: NX_P11831

Human Synonyms: MCM1

Human Chr (Location): 6p21.1; chr6:43171295-43181506 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(1) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit embryonic lethality, abnormal gastrulation, no mesoderm or primitive streak formation and reduced embryo size.
 
Phenotype Images(3)
Interactions
Srf interacts with 371 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (125 annotations)
Process actin cytoskeleton organization, actin filament organization, ...
Component cell, cytoplasm, ...
Function chromatin binding, chromatin DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (50 records)
Data Summary: Results (220)    Tissues (190)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 191
Western blot 13
RT-PCR 16
cDNA source data(73)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase srf ; ZFIN srfa, srfb    NEW 
Molecular
reagents
All nucleic(79) Genomic(2) cDNA(73) Primer pair(4)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000015605 (Evidence)
Entrez Gene 20807 (Evidence)
UniGene 45044
DFCI TC1577357
DoTS DT.531151
NIA Mouse Gene Index U037861
Consensus CDS Project CCDS28831.1
International Mouse Phenotyping Consortium Status Srf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015605 Ensembl Gene Model | MGI Sequence Detail 9324 C57BL/6J ±  kb
transcript ENSMUST00000015749 Ensembl | MGI Sequence Detail 4093 Not Applicable 
polypeptide ENSMUSP00000015749 Ensembl | MGI Sequence Detail 504 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002100 Transcription factor, MADS-box
Protein Ontology PR:000015613 serum response factor
References
(Earliest) J:34031 Latinkic BV, et al., Promoter function and structure of the growth factor-inducible immediate early gene cyr61. Nucleic Acids Res. 1991 Jun 25;19(12):3261-7
(Latest) J:221920 Costello P, et al., MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development. Blood. 2015 Feb 19;125(8):1244-55
All references(168)
Other
accession IDs
MGD-MRK-35116, MGI:2147041, MGI:2147058

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory