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Myo1e Gene Detail
Summary
  • Symbol
    Myo1e
  • Name
    myosin IE
  • Synonyms
    2310020N23Rik, 9130023P14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:106621
    NCBI Gene: 71602
Location & Maps
more
  • Sequence Map
    Chr9:70207350-70400067 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      192718 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MYO1E, myosin IE
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYO1E, myosin IE
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FSGS6, HuncM-IC, MYO1C
  • Links
    NCBI Gene ID: 4643
    neXtProt AC: NX_Q12965

  • Chr Location
    15q22.2; chr15:59135969-59372872 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 55864
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MYO1E
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MYO1E associations

Human Disease Mouse Models
       Focal Segmental Glomerulosclerosis 6; FSGS6   OMIM: 614131
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    74
  • Chemically induced (other)
    1
  • Gene trapped
    71
  • Targeted
    2
  • Genomic Mutations
    1 involving Myo1e
  • Incidental Mutations
Homozygotes for a gene trapped allele exhibit embryonic lethality, embryonic hemorrhaging and hematopoietic defects. Homozygotes for a knock-out allele show proteinuria, chronic renal injury, kidney inflammation, and defects in renal filtration and podocyte organization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 71602 NCBI Gene Model | MGI Sequence Detail 192718 C57BL/6J ±  kb
transcript NM_181072 RefSeq | MGI Sequence Detail 4944 C57BL/6  
polypeptide E9Q634 UniProt | EBI | MGI Sequence Detail 1107 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1213 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010859 myosin-Ie
  • PDB
  • InterPro Domains
    IPR000048 IQ motif, EF-hand binding site
    IPR001609 Myosin head, motor domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001452 SH3 domain
    IPR010926 Unconventional myosin tail, actin- and lipid-binding
Molecular
Reagents
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  • All nucleic 14
    cDNA 13
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-35078, MGI:1913768, MGI:1918852, MGI:2142912
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:35477 Hasson T, et al., Mapping of unconventional myosins in mouse and human. Genomics. 1996 Sep 15;36(3):431-9
  • Latest
    J:200944 Bi J, et al., Myosin 1e is a component of the glomerular slit diaphragm complex that regulates actin reorganization during cell-cell contact formation in podocytes. Am J Physiol Renal Physiol. 2013 Aug;305(4):F532-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory