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Myo1e Gene Detail
Summary
  • Symbol
    Myo1e
  • Name
    myosin IE
  • Synonyms
    2310020N23Rik, 9130023P14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:106621
    NCBI Gene: 71602
  • Gene Overview
    MyGene.info: MYO1E
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:70207350-70399766 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 39.41 cM, cytoband D
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1193 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106621
protein coding gene Chr9:70207350-70400067 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034998
protein coding gene Chr9:70258612-70471841 (+)
A/J MGP_AJ_G0034979
protein coding gene Chr9:67831575-68025439 (+)
AKR/J MGP_AKRJ_G0034908
protein coding gene Chr9:69433386-69629602 (+)
BALB/cJ MGP_BALBcJ_G0034971
protein coding gene Chr9:67552690-67747204 (+)
C3H/HeJ MGP_C3HHeJ_G0034680
protein coding gene Chr9:69954304-70159544 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035490
protein coding gene Chr9:72134939-72342930 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032401
protein coding gene Chr9:67383956-67579930 (+)
CAST/EiJ MGP_CASTEiJ_G0034002
protein coding gene Chr9:70226339-70424335 (+)
CBA/J MGP_CBAJ_G0034653
protein coding gene Chr9:74657645-74866274 (+)
DBA/2J MGP_DBA2J_G0034812
protein coding gene Chr9:67575836-67769919 (+)
FVB/NJ MGP_FVBNJ_G0034754
protein coding gene Chr9:66896395-67090515 (+)
LP/J MGP_LPJ_G0034893
protein coding gene Chr9:70497688-70710423 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034795
protein coding gene Chr9:75740651-75943524 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035512
protein coding gene Chr9:69588667-69793413 (+)
PWK/PhJ MGP_PWKPhJ_G0033706
protein coding gene Chr9:67808091-68011243 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033539
protein coding gene Chr9:69884955-70088723 (+)
WSB/EiJ MGP_WSBEiJ_G0034114
protein coding gene Chr9:69476094-69681731 (+)



Homology
more
  • Human Ortholog
    MYO1E, myosin IE
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYO1E, myosin IE
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FSGS6, HuncM-IC, MYO1C
  • Links
    NCBI Gene ID: 4643
    neXtProt AC: NX_Q12965
    UniProt: Q12965

  • Chr Location
    15q22.2; chr15:59135969-59372872 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 55864
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MYO1E
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MYO1E associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a gene trapped allele exhibit embryonic lethality, embryonic hemorrhaging and hematopoietic defects. Homozygotes for a knock-out allele show proteinuria, chronic renal injury, kidney inflammation, and defects in renal filtration and podocyte organization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032220 Ensembl Gene Model | MGI Sequence Detail 192417 C57BL/6J ±  kb
    transcript ENSMUST00000034745 Ensembl | MGI Sequence Detail 4625 Not Applicable  
    polypeptide ENSMUSP00000034745 Ensembl | MGI Sequence Detail 1107 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-35078, MGI:1913768, MGI:1918852, MGI:2142912
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:35477 Hasson T, et al., Mapping of unconventional myosins in mouse and human. Genomics. 1996 Sep 15;36(3):431-9
    • Latest
      J:285202 Giron-Perez DA, et al., Myo1e modulates the recruitment of activated B cells to inguinal lymph nodes. J Cell Sci. 2020 Mar 2;133(5)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    05/26/2020
    MGI 6.15
    The Jackson Laboratory