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Myo1e
Gene Detail
Symbol

Name
ID
Myo1e
myosin IE
MGI:106621
Synonyms
2310020N23Rik, 9130023P14Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 9
39.41 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr9:70207350-70400067 bp, + strand
From NCBI annotation of GRCm38

  192718 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55864  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYO1E
Gene Tree: Myo1e

Human
homologs
MYO1E, myosin IE
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4643
neXtProt AC: NX_Q12965

Human Synonyms: FSGS6, HuncM-IC, MYO1C

Human Chr (Location): 15q22.2; chr15:59135969-59372872 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MYO1E

Mutations,
alleles, and
phenotypes
All mutations/alleles(73) : Gene trapped(71) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a gene trapped allele exhibit embryonic lethality, embryonic hemorrhaging and hematopoietic defects. Homozygotes for a knock-out allele show proteinuria, chronic renal injury, kidney inflammation, and defects in renal filtration and podocyte organization.
 
Interactions
Myo1e interacts with 225 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process endocytosis, glomerular basement membrane development, ...
Component adherens junction, brush border, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase myo1e.1, myo1e.2 ; ZFIN myo1ea    NEW 
Molecular
reagents
All nucleic(14) cDNA(13) Other(1)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000032220 (Evidence)
Entrez Gene 71602 (Evidence)
DFCI TC1575905, TC1596438, TC1599070, TC1658392
DoTS DT.101381244, DT.101736098, DT.40152478, DT.97404405, DT.99839841
NIA Mouse Gene Index U010704
PDB 2XMF
Consensus CDS Project CCDS40680.1
International Mouse Phenotyping Consortium Status Myo1e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 71602 NCBI Gene Model | MGI Sequence Detail 192718 C57BL/6J ±  kb
transcript NM_181072 RefSeq | MGI Sequence Detail 4944 C57BL/6 
polypeptide E9Q634 UniProt | EBI | MGI Sequence Detail 1107 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(1213 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 SH3 domain
InterPro IPR010926 Unconventional myosin tail, actin- and lipid-binding
Protein Ontology PR:000010859 myosin-Ie
Graphical View of Protein Domain Structure
References
(Earliest) J:35477 Hasson T, et al., Mapping of unconventional myosins in mouse and human. Genomics. 1996 Sep 15;36(3):431-9
(Latest) J:200944 Bi J, et al., Myosin 1e is a component of the glomerular slit diaphragm complex that regulates actin reorganization during cell-cell contact formation in podocytes. Am J Physiol Renal Physiol. 2013 Aug;305(4):F532-44
All references(45)
Other
accession IDs
MGD-MRK-35078, MGI:1913768, MGI:1918852, MGI:2142912

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory