Myo1e
Gene Detail

Symbol Name ID

Myo1e myosin IE MGI:106621

Synonyms

2310020N23Rik, 9130023P14Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 9

39.41 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr9:70207350-70400067 bp, + strand From NCBI annotation of GRCm38   192718 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55864  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Myo1e

Human homologs

Human Homolog		MYO1E, myosin IE
NCBI Gene ID		4643
neXtProt AC		NX_Q12965
Human Synonyms		FSGS6, HuncM-IC, MYO1C
Human Chr (Location)		15q21-q22; chr15:59428168-59665071 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MYO1E

Alleles and phenotypes

All alleles(73) : Targeted(2) Gene trapped(71)
 

Homozygotes for a gene trapped allele exhibit embryonic lethality, embryonic hemorrhaging and hematopoietic defects. Homozygotes for a knock-out allele show proteinuria, chronic renal injury, kidney inflammation, and defects in renal filtration and podocyte organization.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	endocytosis, glomerular basement membrane development, ...
Component	adherens junction, cell-cell junction, ...
Function	actin binding, actin filament binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(12) Other(1)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000032220 (Evidence)
Entrez Gene	71602 (Evidence)
DFCI	TC1575905, TC1596438, TC1599070, TC1658392
DoTS	DT.101381244, DT.101736098, DT.40152478, DT.97404405, DT.99839841
NIA Mouse Gene Index	U010704
PDB	2XMF
Consensus CDS Project	CCDS40680.1
International Mouse Knockout Project Status	Myo1e

Sequences

Length	Strain/Species
genomic	71602	NCBI Gene Model | MGI Sequence Detail	192718	C57BL/6J
transcript	NM_181072	RefSeq | MGI Sequence Detail	4944	C57BL/6
polypeptide	E9Q634	UniProt | EBI | MGI Sequence Detail	1107	Not Applicable

All sequences(41) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(618 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000048	IQ motif, EF-hand binding site
InterPro	IPR001609	Myosin head, motor domain
InterPro	IPR010926	Myosin tail 2
InterPro	IPR001452	Src homology-3 domain
Protein Ontology	PR:000010859	myosin-Ie

Graphical View of Protein Domain Structure

References

(Earliest) J:35477 Hasson T, et al., Mapping of unconventional myosins in mouse and human. Genomics. 1996 Sep 15;36(3):431-9
(Latest) J:188500 Chase SE, et al., Podocyte-specific knockout of myosin 1e disrupts glomerular filtration. Am J Physiol Renal Physiol. 2012 Oct;303(7):F1099-106
All references(42)

Other accession IDs

MGD-MRK-35078, MGI:1913768, MGI:1918852, MGI:2142912