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Spg21
Gene Detail
Symbol

Name
ID
Spg21
spastic paraplegia 21 homolog (human)
MGI:106403
Synonyms
ACP33, BM-019, D9Wsu18e, GL010
Feature Type
protein coding gene
Genetic Map
Chromosome 9
35.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:65460937-65488470 bp, + strand
From NCBI annotation of GRCm38

  27534 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9603  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SPG21
Gene Tree: Spg21

Human
homologs
SPG21, spastic paraplegia 21 (autosomal recessive, Mast syndrome)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51324
neXtProt AC: NX_Q9NZD8

Human Synonyms: ACP33, BM-019, GL010, MAST

Human Chr (Location): 15q22.31; chr15:64963021-64989946 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SPG21

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(9) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Spg21 interacts with 173 markers (Mir7-1, Mir10a, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process biological_process
Component cytoplasm, cytosol, ...
Function CD4 receptor binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (46)    Tissues (5)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 40
RT-PCR 6
cDNA source data(84)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase spg21 ; ZFIN spg21    NEW 
Molecular
reagents
All nucleic(86) cDNA(85) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000032388 (Evidence)
Entrez Gene 27965 (Evidence)
UniGene 272475
DFCI TC1572743
DoTS DT.535362, DT.94263986, DT.97357082
NIA Mouse Gene Index U010637
Consensus CDS Project CCDS23293.1
International Mouse Phenotyping Consortium Status Spg21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 27965 NCBI Gene Model | MGI Sequence Detail 27534 C57BL/6J ±  kb
transcript NM_138584 RefSeq | MGI Sequence Detail 2690 C57BL/6 
polypeptide Q9CQC8 UniProt | EBI | MGI Sequence Detail 308 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(224 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000073 Alpha/beta hydrolase fold-1
InterPro IPR026151 Maspardin
Protein Ontology PR:000015519 maspardin
Graphical View of Protein Domain Structure
References
(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)
Other
accession IDs
MGD-MRK-34096, MGI:2143397

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory