Spg21^tm1Mchan
Targeted Allele Detail

Summary

• Symbol: Spg21^tm1Mchan
• Name: SPG21, maspardin; targeted mutation 1, Michael C Hanna
• MGI ID: MGI:6508399
• Gene: Spg21 Location: Chr9:65368229-65395752 bp, + strand Genetic Position: Chr9, 35.32 cM
• Alliance: Spg21^tm1Mchan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302256
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The luciferase gene and a loxP-flanked neomcycin resistance gene replaced exon 3. Western blot analysis confirmed absence of protein. (J:302256)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spg21 Mutation: 19 strains or lines available

References

• Original: J:302256 Soderblom C, et al., Targeted disruption of the Mast syndrome gene SPG21 in mice impairs hind limb function and alters axon branching in cultured cortical neurons. Neurogenetics. 2010 Oct;11(4):369-78
• All: 2 reference(s)