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Sco1 Gene Detail
Summary
  • Symbol
    Sco1
  • Name
    SCO1 cytochrome c oxidase assembly protein
  • Synonyms
    2610001C07Rik, D11Bwg1310e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106362
    NCBI Gene: 52892
  • Gene Overview
    MyGene.info: SCO1
Location & Maps
more
  • Sequence Map
    Chr11:67052670-67067070 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14401 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 40.59 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SCO1, SCO1, cytochrome c oxidase assembly protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SCO1, SCO1, cytochrome c oxidase assembly protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SCOD1
  • Links
    NCBI Gene ID: 6341
    neXtProt AC: NX_O75880

  • Chr Location
    17p13.1; chr17:10680332-10697568 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Sco1 mouse models; 1 with human SCO1 associations

Human Disease Mouse Models
       Mitochondrial Complex IV Deficiency   OMIM: 220110 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Sco1
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a conditional allele knocked out in the liver exhibit weight loss, premature death, spleen atrophy, reduced white blood cells, increased mitochondria proliferation, increased iron levels in the liver and spleen, and decreased copper levels in the liver and kidney.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005911 VEGA Gene Model | MGI Sequence Detail 14401 C57BL/6J ±  kb
transcript OTTMUST00000013162 VEGA | MGI Sequence Detail 2186 Not Applicable  
polypeptide OTTMUSP00000006110 VEGA | MGI Sequence Detail 289 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    75 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014531 protein SCO1, mitochondrial
  • InterPro Domains
    IPR003782 Copper chaperone SCO1/SenC
    IPR017276 Synthesis of cytochrome c oxidase, Sco1/Sco2
    IPR013766 Thioredoxin domain
    IPR012336 Thioredoxin-like fold
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-34054, MGI:1914354
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:222036 Hlynialuk CJ, et al., The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis. Cell Rep. 2015 Feb 12;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory