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Sco1 Gene Detail
Summary
  • Symbol
    Sco1
  • Name
    SCO1 cytochrome c oxidase assembly protein
  • Synonyms
    2610001C07Rik, D11Bwg1310e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106362
    NCBI Gene: 52892
  • Gene Overview
    MyGene.info: SCO1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:67052670-67067070 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 40.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106362
protein coding gene Chr11:67052670-67067444 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018484
protein coding gene Chr11:67329437-67344640 (+)
A/J MGP_AJ_G0018453
protein coding gene Chr11:64806737-64821127 (+)
AKR/J MGP_AKRJ_G0018422
protein coding gene Chr11:66749853-66764245 (+)
BALB/cJ MGP_BALBcJ_G0018424
protein coding gene Chr11:65092936-65107328 (+)
C3H/HeJ MGP_C3HHeJ_G0018237
protein coding gene Chr11:66758695-66773082 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018876
protein coding gene Chr11:69362935-69378585 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016520
protein coding gene Chr11:61770920-61783681 (+)
CAST/EiJ MGP_CASTEiJ_G0017793
protein coding gene Chr11:66984357-66998737 (+)
CBA/J MGP_CBAJ_G0018211
protein coding gene Chr11:72411420-72425814 (+)
DBA/2J MGP_DBA2J_G0018320
protein coding gene Chr11:64354119-64368509 (+)
FVB/NJ MGP_FVBNJ_G0018310
protein coding gene Chr11:64015662-64030059 (+)
LP/J MGP_LPJ_G0018392
protein coding gene Chr11:67879727-67898942 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018334
protein coding gene Chr11:73239382-73253774 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018917
protein coding gene Chr11:66981854-66996240 (+)
PWK/PhJ MGP_PWKPhJ_G0017567
protein coding gene Chr11:65012855-65027224 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017357
protein coding gene Chr11:66807345-66821725 (+)
WSB/EiJ MGP_WSBEiJ_G0017846
protein coding gene Chr11:66598253-66613584 (+)



Homology
more
  • Human Ortholog
    SCO1, SCO1, cytochrome c oxidase assembly protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SCO1, SCO1, cytochrome c oxidase assembly protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SCOD1
  • Links
    NCBI Gene ID: 6341
    neXtProt AC: NX_O75880
    UniProt: O75880

  • Chr Location
    17p13.1; chr17:10679770-10697568 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Sco1 mouse models; 1 with human SCO1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele knocked out in the liver exhibit weight loss, premature death, spleen atrophy, reduced white blood cells, increased mitochondria proliferation, increased iron levels in the liver and spleen, and decreased copper levels in the liver and kidney.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000069844 Ensembl Gene Model | MGI Sequence Detail 14401 C57BL/6J ±  kb
    transcript ENSMUST00000108690 Ensembl | MGI Sequence Detail 2186 Not Applicable  
    polypeptide ENSMUSP00000104330 Ensembl | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR003782 Copper chaperone SCO1/SenC
      IPR017276 Synthesis of cytochrome c oxidase, Sco1/Sco2
      IPR013766 Thioredoxin domain
      IPR036249 Thioredoxin-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-34054, MGI:1914354
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:252376 Baker ZN, et al., The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart. Hum Mol Genet. 2017 Dec 1;26(23):4617-4628

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory