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Bcl11a
Gene Detail
Symbol

Name
ID
Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
MGI:106190
Synonyms
2810047E18Rik, COUP-TF interacting protein 1, CTIP1, D930021L15Rik, Evi9, Evi9a, Evi9b, Evi9c, mKIAA1809, mouse myeloid leukemia gene
Feature Type
protein coding gene
Genetic Map
Chromosome 11
14.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:24078056-24174123 bp, + strand
From VEGA annotation of GRCm38

  96068 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11284  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Bcl11a

Human
homologs
Human Homolog BCL11A, B-cell CLL/lymphoma 11A (zinc finger protein)
NCBI Gene ID 53335
neXtProt AC  NX_Q9H165
Human Synonyms  BCL11A-L, BCL11a-M, BCL11A-S, BCL11A-XL, CTIP1, EVI9, HBFQTL5, ZNF856
Human Chr (Location)  2p16.1; chr2:60451167-60553498 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(3) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in B cell deficiency, alteration of T cell types, and neonatal lethality.
 
Interactions
Bcl11a interacts with 475 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process B cell differentiation, negative regulation of collateral sprouting, ...
Component cytoplasm, nuclear body, ...
Function metal ion binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (168)    Tissues (68)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 128
Northern blot 13
RT-PCR 27
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(19) Primer pair(3) Other(2)
Microarray probesets(10)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005291 VEGA Gene Model | MGI Sequence Detail 96068 C57BL/6J ±  kb
transcript OTTMUST00000011806 VEGA | MGI Sequence Detail 5989 Not Applicable 
polypeptide OTTMUSP00000005479 VEGA | MGI Sequence Detail 835 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(16) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(249 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000004690 B-cell lymphoma/leukemia 11A
References
(Earliest) J:31569 Nakamura T, et al., Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias [see comments]. Nat Genet. 1996 Feb;12(2):149-53
(Latest) J:207383 Ippolito GC, et al., Dendritic cell fate is determined by BCL11A. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E998-E1006
All references(65)
Other
accession IDs
MGD-MRK-33881, MGI:1919958, MGI:2442002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory