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Bcl11a Gene Detail
Summary
  • Symbol
    Bcl11a
  • Name
    B cell CLL/lymphoma 11A (zinc finger protein)
  • Synonyms
    2810047E18Rik, COUP-TF interacting protein 1, CTIP1, D930021L15Rik, Evi9, Evi9a, Evi9b, Evi9c, mKIAA1809, mouse myeloid leukemia gene
  • Feature Type
    protein coding gene
  • IDs
    MGI:106190
    NCBI Gene: 14025
  • Gene Overview
    MyGene.info: BCL11A
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:24078056-24174123 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 14.41 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    250 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106190
protein coding gene Chr11:24076544-24174123 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018095
protein coding gene Chr11:21869302-21968691 (+)
A/J MGP_AJ_G0018068
protein coding gene Chr11:21008883-21106367 (+)
AKR/J MGP_AKRJ_G0018032
protein coding gene Chr11:21759213-21858409 (+)
BALB/cJ MGP_BALBcJ_G0018036
protein coding gene Chr11:21159542-21257770 (+)
C3H/HeJ MGP_C3HHeJ_G0017850
protein coding gene Chr11:21643765-21741923 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018488
protein coding gene Chr11:22750607-22858341 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016146
protein coding gene Chr11:19892521-19988647 (+)
CAST/EiJ MGP_CASTEiJ_G0017411
protein coding gene Chr11:21676980-21784581 (+)
CBA/J MGP_CBAJ_G0017824
protein coding gene Chr11:23717423-23833511 (+)
DBA/2J MGP_DBA2J_G0017934
protein coding gene Chr11:20930413-21027912 (+)
FVB/NJ MGP_FVBNJ_G0017926
protein coding gene Chr11:20717346-20816111 (+)
LP/J MGP_LPJ_G0018005
protein coding gene Chr11:21966135-22071168 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017952
protein coding gene Chr11:24287027-24388930 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018529
protein coding gene Chr11:21863890-21966004 (+)
PWK/PhJ MGP_PWKPhJ_G0017192
protein coding gene Chr11:20995753-21092537 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016989
protein coding gene Chr11:21623472-21722805 (+)
WSB/EiJ MGP_WSBEiJ_G0017465
protein coding gene Chr11:21500106-21605208 (+)



Homology
more
  • Human Ortholog
    BCL11A, BAF chromatin remodeling complex subunit BCL11A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    BCL11A, BAF chromatin remodeling complex subunit BCL11A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCL11A-L, BCL11a-M, BCL11A-S, BCL11A-XL, CTIP1, DILOS, EVI9, HBFQTL5, ZNF856
  • Links
    NCBI Gene ID: 53335
    neXtProt AC: NX_Q9H165
    UniProt: Q9H165

  • Chr Location
    2p16.1; chr2:60451167-60553498 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 7 alleles in 8 genetic backgrounds
    20 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in B cell deficiency, alteration of T cell types, and neonatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000861 Ensembl Gene Model | MGI Sequence Detail 96068 C57BL/6J ±  kb
    transcript ENSMUST00000109514 Ensembl | MGI Sequence Detail 5989 Not Applicable  
    polypeptide ENSMUSP00000105140 Ensembl | MGI Sequence Detail 835 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 20
      Primer pair 4
      Other 3

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-33881, MGI:1919958, MGI:2442002
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 34
      Gene Ontology 9
      Phenotypes 29
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:271614 Gudmundsdottir B, et al., POGZ Is Required for Silencing Mouse Embryonic beta-like Hemoglobin and Human Fetal Hemoglobin Expression. Cell Rep. 2018 Jun 12;23(11):3236-3248

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory