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Bcl11a
Gene Detail
 Symbol
Name
ID
Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
MGI:106190
Synonyms 2810047E18Rik, COUP-TF interacting protein 1, CTIP1, D930021L15Rik, Evi9, Evi9a, Evi9b, Evi9c, mKIAA1809, mouse myeloid leukemia gene
Feature Type protein coding gene
Genetic Map
Chromosome 11
14.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:24078056-24174123 bp, + strand
From VEGA annotation of GRCm38

  96068 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11284  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 chicken; 1 zebrafish

Gene Tree: Bcl11a

Human
homologs
Human Homolog BCL11A, B-cell CLL/lymphoma 11A (zinc finger protein)
NCBI Gene ID 53335
neXtProt AC  NX_Q9H165
Human Synonyms  BCL11A-L, BCL11a-M, BCL11A-S, BCL11A-XL, CTIP1, EVI9, HBFQTL5, ZNF856
Human Chr (Location)  2p16.1; chr2:60451167-60553498 (-)  GRCh38
Alleles
and
phenotypes
All alleles(14) : Gene trapped(3) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in B cell deficiency, alteration of T cell types, and neonatal lethality.
 
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process B cell differentiation, negative regulation of collateral sprouting, ...
Component cytoplasm, nuclear body, ...
Function metal ion binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (168)    Tissues (68)    Images (48)
Theiler Stages: 10, 17, 18, 19, 20, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 128
Northern blot 13
RT-PCR 27
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(24) cDNA(19) Primer pair(3) Other(2)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000005291 (Evidence)
Ensembl Gene ModelENSMUSG00000000861 (Evidence)
Entrez Gene14025 (Evidence)
DFCITC1581401, TC1585693, TC1592985, TC1595520, TC1602313, TC1645258, TC1665747, TC1727266
DoTSDT.101382447, DT.40178101, DT.55183483, DT.55249405, DT.91326005, DT.94156216, DT.94196951, DT.97396213
NIA Mouse Gene IndexU012391
Consensus CDS ProjectCCDS24483.1, CCDS48758.1, CCDS48759.1, CCDS56764.1
International Mouse Knockout Project StatusBcl11a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005291 VEGA Gene Model | MGI Sequence Detail 96068 C57BL/6J ±  kb
transcript OTTMUST00000011806 VEGA | MGI Sequence Detail 5989 Not Applicable 
polypeptide OTTMUSP00000005479 VEGA | MGI Sequence Detail 835 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(16) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(249 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000004690 B-cell lymphoma/leukemia 11A
References (Earliest) J:31569 Nakamura T, et al., Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias [see comments]. Nat Genet. 1996 Feb;12(2):149-53
(Latest) J:207383 Ippolito GC, et al., Dendritic cell fate is determined by BCL11A. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E998-E1006
All references(65)
Other
accession IDs
MGD-MRK-33881, MGI:1919958, MGI:2442002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory