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Bcl11a Gene Detail
Summary
  • Symbol
    Bcl11a
  • Name
    B cell CLL/lymphoma 11A (zinc finger protein)
  • Synonyms
    2810047E18Rik, COUP-TF interacting protein 1, CTIP1, D930021L15Rik, Evi9, Evi9a, Evi9b, Evi9c, mKIAA1809, mouse myeloid leukemia gene
  • Feature Type
    protein coding gene
  • IDs
    MGI:106190
    NCBI Gene: 14025
  • Gene Overview
    MyGene.info: BCL11A
Location & Maps
more
  • Sequence Map
    Chr11:24078056-24174123 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      96068 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 14.41 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BCL11A, B-cell CLL/lymphoma 11A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    BCL11A, B-cell CLL/lymphoma 11A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCL11A-L, BCL11a-M, BCL11A-S, BCL11A-XL, CTIP1, DILOS, EVI9, HBFQTL5, ZNF856
  • Links
    NCBI Gene ID: 53335
    neXtProt AC: NX_Q9H165

  • Chr Location
    2p16.1; chr2:60451167-60553498 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human BCL11A associations

Human Disease Mouse Models
       Intellectual Developmental Disorder with Persistence of Fetal Hemoglobin   OMIM: 617101
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 7 alleles in 8 genetic backgrounds
    20 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    13
  • Genomic Mutations
    1 involving Bcl11a
  • Incidental Mutations
Homozygous mutation of this gene results in B cell deficiency, alteration of T cell types, and neonatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005291 VEGA Gene Model | MGI Sequence Detail 96068 C57BL/6J ±  kb
transcript OTTMUST00000011806 VEGA | MGI Sequence Detail 5989 Not Applicable  
polypeptide OTTMUSP00000005479 VEGA | MGI Sequence Detail 835 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    250 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000004690 B-cell lymphoma/leukemia 11A
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 25
    cDNA 19
    Primer pair 3
    Other 3

    Microarray probesets 10
Other
Accession IDs
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MGD-MRK-33881, MGI:1919958, MGI:2442002
References
more
  • Summaries
    All 68
    Developmental Gene Expression 24
    Gene Ontology 9
    Phenotypes 23
  • Earliest
    J:31569 Nakamura T, et al., Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias [see comments]. Nat Genet. 1996 Feb;12(2):149-53
  • Latest
    J:227426 Wiegreffe C, et al., Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c. Neuron. 2015 Jul 15;87(2):311-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory