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Bcl11a
Gene Detail
Symbol

Name
ID
Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
MGI:106190
Synonyms
2810047E18Rik, COUP-TF interacting protein 1, CTIP1, D930021L15Rik, Evi9, Evi9a, Evi9b, Evi9c, mKIAA1809, mouse myeloid leukemia gene
Feature Type
protein coding gene
Genetic Map
Chromosome 11
14.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:24078056-24174123 bp, + strand
From VEGA annotation of GRCm38

  96068 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11284  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BCL11A
Gene Tree: Bcl11a

Human
homologs
BCL11A, B-cell CLL/lymphoma 11A (zinc finger protein)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 53335
neXtProt AC: NX_Q9H165

Human Synonyms: BCL11A-L, BCL11a-M, BCL11A-S, BCL11A-XL, CTIP1, EVI9, HBFQTL5, ZNF856

Human Chr (Location): 2p16.1; chr2:60451167-60553498 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(3) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in B cell deficiency, alteration of T cell types, and neonatal lethality.
 
Interactions
Bcl11a interacts with 475 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process B cell differentiation, negative regulation of collateral sprouting, ...
Component cytoplasm, nuclear body, ...
Function metal ion binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (168)    Tissues (68)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 128
Northern blot 13
RT-PCR 27
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase bcl11a ; ZFIN bcl11aa, bcl11ab    NEW 
Molecular
reagents
All nucleic(24) cDNA(19) Primer pair(3) Other(2)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000005291 (Evidence)
Ensembl Gene Model ENSMUSG00000000861 (Evidence)
Entrez Gene 14025 (Evidence)
DFCI TC1581401, TC1585693, TC1592985, TC1595520, TC1602313, TC1645258, TC1665747, TC1727266
DoTS DT.101382447, DT.40178101, DT.55183483, DT.55249405, DT.91326005, DT.94156216, DT.94196951, DT.97396213
NIA Mouse Gene Index U012391
Consensus CDS Project CCDS24483.1, CCDS48758.1, CCDS48759.1, CCDS56764.1
International Mouse Phenotyping Consortium Status Bcl11a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005291 VEGA Gene Model | MGI Sequence Detail 96068 C57BL/6J ±  kb
transcript OTTMUST00000011806 VEGA | MGI Sequence Detail 5989 Not Applicable 
polypeptide OTTMUSP00000005479 VEGA | MGI Sequence Detail 835 Not Applicable 

For the selected sequences
All sequences(98) RefSeq(22) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(249 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000004690 B-cell lymphoma/leukemia 11A
References
(Earliest) J:31569 Nakamura T, et al., Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias [see comments]. Nat Genet. 1996 Feb;12(2):149-53
(Latest) J:207383 Ippolito GC, et al., Dendritic cell fate is determined by BCL11A. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E998-E1006
All references(64)
Other
accession IDs
MGD-MRK-33881, MGI:1919958, MGI:2442002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory