Bcl11a
Gene Detail

Symbol Name ID

Bcl11a B cell CLL/lymphoma 11A (zinc finger protein) MGI:106190

Synonyms

2810047E18Rik, COUP-TF interacting protein 1, CTIP1, D930021L15Rik, Evi9, Evi9a, Evi9b, Evi9c, mKIAA1809, mouse myeloid leukemia gene

Feature Type

protein coding gene

Genetic Map

Chromosome 11

14.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:24078056-24174123 bp, + strand From VEGA annotation of GRCm38   96068 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11284  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Bcl11a

Human homologs

Human Homolog		BCL11A, B-cell CLL/lymphoma 11A (zinc finger protein)
NCBI Gene ID		53335
neXtProt AC		NX_Q9H165
Human Synonyms		BCL11A-L, BCL11a-M, BCL11A-S, BCL11A-XL, CTIP1, EVI9, HBFQTL5, ZNF856
Human Chr (Location)		2p16.1; chr2:60678302-60780633 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(13) : Targeted(10) Gene trapped(3)
 

Homozygous mutation of this gene results in B cell deficiency, alteration of T cell types, and neonatal lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	B cell differentiation, negative regulation of collateral sprouting, ...
Component	cytoplasm, nuclear body, ...
Function	metal ion binding, nucleic acid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (168)    Tissues (68)    Images (48)
Theiler Stages: 10, 17, 18, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	128
Northern blot	13
RT-PCR	27

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(19) Primer pair(3) Other(2)
Microarray probesets(10)

Other database links

VEGA Gene Model	OTTMUSG00000005291 (Evidence)
Ensembl Gene Model	ENSMUSG00000000861 (Evidence)
Entrez Gene	14025 (Evidence)
DFCI	TC1581401, TC1585693, TC1592985, TC1595520, TC1602313, TC1645258, TC1665747, TC1727266
DoTS	DT.101382447, DT.40178101, DT.55183483, DT.55249405, DT.91326005, DT.94156216, DT.94196951, DT.97396213
NIA Mouse Gene Index	U012391
Consensus CDS Project	CCDS24483.1, CCDS48758.1, CCDS48759.1, CCDS56764.1
International Mouse Knockout Project Status	Bcl11a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005291	VEGA Gene Model | MGI Sequence Detail	96068	C57BL/6J
transcript	OTTMUST00000011806	VEGA | MGI Sequence Detail	5989	Not Applicable
polypeptide	OTTMUSP00000005479	VEGA | MGI Sequence Detail	835	Not Applicable

All sequences(86) RefSeq(8) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(189 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000004690	B-cell lymphoma/leukemia 11A

References

(Earliest) J:31569 Nakamura T, et al., Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias [see comments]. Nat Genet. 1996 Feb;12(2):149-53
(Latest) J:194616 Yu Y, et al., Bcl11a is essential for lymphoid development and negatively regulates p53. J Exp Med. 2012 Dec 17;209(13):2467-83
All references(59)

Other accession IDs

MGD-MRK-33881, MGI:1919958, MGI:2442002