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Npm1
Gene Detail
Symbol

Name
ID
Npm1
nucleophosmin 1
MGI:106184
Synonyms
B23, NO38, nucleolar protein NO38
Feature Type
protein coding gene
Genetic Map
Chromosome 11
19.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:33152287-33163206 bp, - strand
From VEGA annotation of GRCm38

  10920 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81697  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: nucleophosmin
Gene Tree: Npm1

Human
homologs
Human Homolog NPM1, nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NCBI Gene ID 4869
neXtProt AC  NX_P06748
Human Synonyms  B23, NPM
Human Chr (Location)  5q35.1; chr5:171387648-171410884 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Gene trapped(37) Targeted(5)
 
Homozygous mutation of this gene results in embryonic lethality, anemia, defects in primitive hematopoeisis and abnormal brain development. Heterozygous mutation results in hematopoeisis defects and chromosomal instability.
 
Phenotype Images(2)
Interactions
Npm1 interacts with 155 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (98 annotations)
Process cell aging, cell growth, ...
Component cell, centrosome, ...
Function DNA binding, enzyme binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (56)    Tissues (17)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 7
RT-PCR 36
cDNA source data(1036)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(1040) cDNA(1038) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005395 VEGA Gene Model | MGI Sequence Detail 10920 C57BL/6J ±  kb
transcript OTTMUST00000012025 VEGA | MGI Sequence Detail 1633 Not Applicable 
polypeptide OTTMUSP00000005572 VEGA | MGI Sequence Detail 292 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(8) UniProt(19)
Polymorphisms
SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004301 Nucleoplasmin
InterPro IPR024057 Nucleoplasmin core domain
Protein Ontology PR:000011370 nucleophosmin
References
(Earliest) J:13854 Otto J, Submandibular gland esterproteases. Mouse News Lett. 1980;63:12
(Latest) J:203748 Wang Z, et al., Nucleophosmin, a critical Bax cofactor in ischemia-induced cell death. Mol Cell Biol. 2013 May;33(10):1916-24
All references(95)
Other
accession IDs
MGD-MRK-33874

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory