Npm1
Gene Detail

Symbol Name ID

Npm1 nucleophosmin 1 MGI:106184

Synonyms

B23, NO38, nucleolar protein NO38

Feature Type

protein coding gene

Genetic Map

Chromosome 11

19.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:33152287-33163206 bp, - strand From VEGA annotation of GRCm38   10920 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Npm1 ± 2 cM)

Protein SuperFamily: nucleophosmin
Gene Tree: Npm1

Human ortholog

NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) NCBI Gene ID 4869
Human Synonyms: B23, NPM
Human Chr5:170814708-170837888 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human NPM1 (1)

Alleles and phenotypes

All alleles(40) : Targeted(3) Gene trapped(37)
 

Homozygous mutation of this gene results in embryonic lethality, anemia, defects in primitive hematopoeisis and abnormal brain development. Heterozygous mutation results in hematopoeisis defects and chromosomal instability.

 

Gene Ontology (GO) classifications

All GO classifications: (86 annotations)

Process	cell aging, cell growth, ...
Component	centrosome, cytoplasm, ...
Function	DNA binding, enzyme binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (22 records)
Data Summary: Results (55)    Tissues (16)    Images (6)
Theiler Stages: 1, 2, 3, 4, 17, 21, 23, 25, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	7
RT-PCR	36

cDNA source data(1041)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(1045) cDNA(1043) Primer pair(1) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000005395 (Evidence)
Ensembl Gene Model	ENSMUSG00000057113 (Evidence)
Entrez Gene	18148 (Evidence)
UniGene	485384
DFCI	TC1573652, TC1575434, TC1600773, TC1699334
DoTS	DT.101200099, DT.102553416, DT.103581379, DT.55128410, DT.91372346, DT.94144570, DT.94214485, DT.94214573, DT.94214582, DT.94214609, DT.94214628
Consensus CDS Project	CCDS24532.1, CCDS56765.1
International Mouse Knockout Project Status	Npm1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005395	VEGA Gene Model | MGI Sequence Detail	10920	C57BL/6J
transcript	OTTMUST00000012025	VEGA | MGI Sequence Detail	1633	Not Applicable
polypeptide	OTTMUSP00000005572	VEGA | MGI Sequence Detail	292	Not Applicable

All sequences(80) RefSeq(6) UniProt(10)

Polymorphisms

SNPs(4 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004301	Nucleoplasmin
InterPro	IPR024057	Nucleoplasmin core
Protein Ontology	PR:000011370	nucleophosmin

References

(Earliest) J:13854 Otto J, Submandibular gland esterproteases. Mouse News Lett. 1980;63:12
(Latest) J:192847 Bhaskaran N, et al., Fbw7alpha and Fbw7gamma collaborate to shuttle cyclin E1 into the nucleolus for multiubiquitylation. Mol Cell Biol. 2013 Jan;33(1):85-97
All references(87)

Other accession IDs

MGD-MRK-33874