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Cyp7a1
Gene Detail
 Symbol
Name
ID
Cyp7a1
cytochrome P450, family 7, subfamily a, polypeptide 1
MGI:106091
Synonyms cholesterol 7 alpha hydroxylase
Feature Type protein coding gene
Genetic Map
Chromosome 4
2.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:6265612-6275633 bp, - strand
From VEGA annotation of GRCm38

  10022 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30987  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cytochrome P450, CYP7A1 type
Gene Tree: Cyp7a1

Human
homologs
Human Homolog CYP7A1, cytochrome P450, family 7, subfamily A, polypeptide 1
NCBI Gene ID 1581
neXtProt AC  NX_P22680
Human Synonyms  CP7A, CYP7, CYPVII
Human Chr (Location)  8q11-q12; chr8:58490178-58500161 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene experience severe neonatal and postnatal lethality. Supplementation of the maternal diet with fat soluble vitamins and cholic acid starting before birth alleviates much of the phenotype.
 
Phenotype Images(3)
Interactions
Cyp7a1 interacts with 287 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process bile acid biosynthetic process, cellular response to cholesterol, ...
Component endoplasmic reticulum, intracellular membrane-bounded organelle, ...
Function cholesterol 7-alpha-monooxygenase activity, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(3) cDNA(17) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000004315 (Evidence)
Ensembl Gene ModelENSMUSG00000028240 (Evidence)
Entrez Gene13122 (Evidence)
UniGene57029
DFCITC1584365
DoTSDT.40183723
NIA Mouse Gene IndexU024821
EC1.14.13.17
Consensus CDS ProjectCCDS17950.1
International Mouse Knockout Project StatusCyp7a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004315 VEGA Gene Model | MGI Sequence Detail 10022 C57BL/6J ±  kb
transcript OTTMUST00000009776 VEGA | MGI Sequence Detail 4172 Not Applicable 
polypeptide OTTMUSP00000004700 VEGA | MGI Sequence Detail 503 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(6) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002403 Cytochrome P450, E-class, group IV
Protein Ontology PR:000006148 cytochrome P450 7A1
References (Earliest) J:18307 Tzung KW, et al., Structure of the mouse cholesterol 7 alpha-hydroxylase gene. Genomics. 1994 May 1;21(1):244-7
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(62)
Other
accession IDs
MGD-MRK-33776

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory